INT64958

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.58
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
blood 2
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 98.80 Very High Very High Very High
Arthritis 14 97.52 Very High Very High Very High
Inflammation 135 95.40 Very High Very High Very High
Infliximab 5 87.32 High High
Osteoarthritis 87 85.76 High High
Etanercept 7 72.40 Quite High
corticosteroid 5 72.08 Quite High
cytokine 55 66.96 Quite High
agonist 44 61.48 Quite High
Pain 29 59.64 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 5 98.84 Very High Very High Very High
Juvenile Chronic Polyarthritis 1 97.52 Very High Very High Very High
Adhesions 14 97.20 Very High Very High Very High
Disease 50 95.56 Very High Very High Very High
INFLAMMATION 156 95.40 Very High Very High Very High
Autoimmune Disease 1 94.56 High High
Purpura 6 94.32 High High
Skin Diseases 4 93.32 High High
Atherosclerosis 44 89.84 High High
Aging 23 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of IL-6 mRNA induced by Ang II was completely blocked by an Ang II type 1 receptor antagonist, CV11974.
Negative_regulation (blocked) of Transcription (expression) of IL-6 associated with antagonist
1) Confidence 0.50 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.51 Pain Relevance 0.08
There is substantial evidence that the increase in IL-6 serum levels with age results in part from the loss of sex steroids such as estrogen, testosterone and dehydroepiandrosterone [36,37], which have an important role in blocking transcription of the IL-6 gene, so that their loss at menopause may have a more conspicuous role than the genotype.
Negative_regulation (blocking) of Transcription (transcription) of IL-6 associated with endometriosis (extended)
2) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.81 Pain Relevance 0.34
Tenidap induced a somewhat similar reduction pattern of IL-1 beta and IL-6 mRNA to that observed for cytokine synthesis.
Negative_regulation (reduction) of Transcription (pattern) of IL-6
3) Confidence 0.39 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8838503 Disease Relevance 0 Pain Relevance 0
It has been demonstrated that thalidomide selectively inhibits the TNF-alpha and IL-6 mRNA expression in human peripheral blood mononuclear cells [10].
Negative_regulation (inhibits) of Transcription (expression) of IL-6 in blood
4) Confidence 0.24 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2831027 Disease Relevance 1.24 Pain Relevance 0.30
In the present study, we have demonstrated that KBG treatment significantly suppressed the protein and mRNA levels of MIF, IL-6, IL-8, and TNF-?
Negative_regulation (suppressed) of Transcription (levels) of IL-6
5) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.56 Pain Relevance 0.14
and its ligands effectively blocked IL-6 transcription and secretion from BMSCs that is induced in response to myeloma cell adhesion [212].
Negative_regulation (blocked) of Transcription (transcription) of IL-6 associated with adhesions
6) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.46 Pain Relevance 0.06

General Comments

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