INT6496

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Context Info
Confidence 0.24
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 3.33
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eye 2
neurons 1
brain 1
co (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 9 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 6 100.00 Very High Very High Very High
Glutamate receptor 6 100.00 Very High Very High Very High
tetrodotoxin 8 99.42 Very High Very High Very High
Neurotransmitter 3 98.04 Very High Very High Very High
Hippocampus 1 96.80 Very High Very High Very High
Pain 12 95.32 Very High Very High Very High
cINOD 5 94.76 High High
Pyramidal cell 3 89.44 High High
IPN 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperlipidemia 18 97.92 Very High Very High Very High
Nociception 2 97.52 Very High Very High Very High
Periodontitis 2 97.52 Very High Very High Very High
Myalgia 9 95.32 Very High Very High Very High
Systemic Lupus Erythematosus 30 94.92 High High
INFLAMMATION 2 94.56 High High
Disease Progression 3 92.20 High High
Stress 180 90.88 High High
Hepatotoxicity 9 81.68 Quite High
Congenital Anomalies 9 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared with the pattern of CO staining, levels of both CO and zinc were reduced in cortical territory innervated by the enucleated eye.
Gene_expression (levels) of CO in eye
1) Confidence 0.24 Published 2003 Journal Cereb. Cortex Section Abstract Doc Link 12967926 Disease Relevance 0 Pain Relevance 0.08
The TTX injection indirectly causes a decrease in cytochrome oxidase (CO) expression in the cortical ODCs corresponding to the treated eye (Wong-Riley & Carroll, 1984).
Gene_expression (expression) of CO in eye associated with tetrodotoxin
2) Confidence 0.09 Published 1997 Journal Vis. Neurosci. Section Abstract Doc Link 9147477 Disease Relevance 0 Pain Relevance 0.41
CoQ in the cytosolic fraction was expressed as pmol per mg protein.


Gene_expression (expressed) of CoQ
3) Confidence 0.06 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0 Pain Relevance 0
In the present study, the levels of CoQ, in cytoplasm where NADPH-CoQ reductase are present, as well as in the mitochondria were measured (Table 1), and the results confirmed that statin administration reduces CoQ levels in mitochondria and cytoplasm among intracellular organelles.


Gene_expression (levels) of CoQ
4) Confidence 0.06 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.23 Pain Relevance 0.10
Decrease in CoQ levels induced by oral administration of HMG-CoA reductase inhibitor
Gene_expression (levels) of CoQ
5) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.10 Pain Relevance 0
Measurement of CoQ levels in serum, cytosolic fraction and tissue
Gene_expression (levels) of CoQ
6) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0 Pain Relevance 0
In the present study, the levels of CoQ, in cytoplasm where NADPH-CoQ reductase are present, as well as in the mitochondria were measured (Table 1), and the results confirmed that statin administration reduces CoQ levels in mitochondria and cytoplasm among intracellular organelles.


Gene_expression (reductase) of CoQ
7) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.23 Pain Relevance 0.09
We have reported previously [20–22] that a novel cytosolic NADPH-CoQ reductase is responsible for the reduction of CoQ10 to H2CoQ10 in biomembranes.
Gene_expression (reductase) of CoQ
8) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.70 Pain Relevance 0
CoQ is distributed not only in mitochondria, but also in other subcellular fractions [17–19], and some CoQ always presents as reduced CoQ (H2CoQ) [18].
Gene_expression (presents) of CoQ
9) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.65 Pain Relevance 0
These results suggested that oral administration of simvastatin suppresses the biosynthesis of CoQ, which shares the same biosynthesis pathway as cholesterol up to farnesyl pyrophosphate, thus compromising the physiological function of reduced CoQ, which possesses antioxidant activity.
Gene_expression (biosynthesis) of CoQ
10) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2275764 Disease Relevance 0.24 Pain Relevance 0
Therefore, statins affect CoQ biosynthesis greatly.
Gene_expression (biosynthesis) of CoQ
11) Confidence 0.04 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.08 Pain Relevance 0
This investigation focuses on the changes in the concentrations of cyclooxygenase (CO) products present within the crevicular fluid in naturally-progressing periodontitis in the beagle and the effects of various non-steroidal anti-inflammatory drugs (NSAIDs) on these metabolite levels and disease progression.
Gene_expression (products) of CO associated with inflammation, periodontitis, cinod and disease progression
12) Confidence 0.04 Published 1992 Journal J. Periodont. Res. Section Abstract Doc Link 1608034 Disease Relevance 0.51 Pain Relevance 0.26
We hypothesized that the distribution of Na+,K(+)-ATPase in brain would correlate with that of the energy-producing enzyme, cytochrome oxidase (CO).
Gene_expression (producing) of CO in brain
13) Confidence 0.04 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1328957 Disease Relevance 0 Pain Relevance 0.13
In the present study, we hypothesized that the expressions of glutamate receptor, NMDA receptors (NMDAR1) and neuronal nitric oxide synthase (nNOS) were colocalized and were also correlated with that of cytochrome oxidase (CO) in a subset of neurons.
Gene_expression (expressions) of CO in neurons associated with nmda receptor, glutamate receptor and neuronal nitric oxide synthase
14) Confidence 0.03 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10800203 Disease Relevance 0 Pain Relevance 0.32
We found a difference in the sequence of developmental expressions of NMDAR1, nNOS, CO, and Na(+)/K(+) ATPase.
Gene_expression (expressions) of CO
15) Confidence 0.02 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10800203 Disease Relevance 0 Pain Relevance 0.36
One week of tetrodotoxin significantly decreased the expression of NMDAR1, nNOS, and CO activity.
Gene_expression (expression) of CO associated with tetrodotoxin
16) Confidence 0.02 Published 1999 Journal J. Neurocytol. Section Abstract Doc Link 10800203 Disease Relevance 0 Pain Relevance 0.37
Intraperitoneal (i.p.) administration of cobalt protoporphyrin (CoPP, an HO-1 inducer, 5mg/kg) 24h before the test, inhibited the nociceptive response during the second phase, but not during the first phase of the formalin test.
Gene_expression (administration) of CoPP associated with nociception
17) Confidence 0.01 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.27 Pain Relevance 0.11
In order to understand the effects of CpG and E2 on the activation of PDCs, we firstly test the viability and the expression of co-stimulatory molecules on PDCs.
Gene_expression (expression) of co-stimulatory
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.33 Pain Relevance 0

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