INT64965

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Context Info
Confidence 0.10
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.53
Pain Relevance 0.45

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cell differentiation (AGFG1) transport (AGFG1) Golgi apparatus (AGFG1)
RNA binding (AGFG1) cytoplasmic membrane-bounded vesicle (AGFG1) nucleus (AGFG1)
Anatomy Link Frequency
osteoclast 1
Respiratory 1
AGFG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 100.00 Very High Very High Very High
agonist 1 93.68 High High
Pain 9 92.88 High High
opioid receptor 1 92.32 High High
anesthesia 5 87.96 High High
Potency 2 75.00 Quite High
headache 7 37.00 Quite Low
antagonist 4 18.64 Low Low
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
lancinating pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 58 100.00 Very High Very High Very High
INFLAMMATION 1 100.00 Very High Very High Very High
Diabetes Mellitus 20 99.92 Very High Very High Very High
Communicable Diseases 5 99.12 Very High Very High Very High
Bacterial Meningitis 1 98.52 Very High Very High Very High
Respiratory Syncytial Virus 1 98.44 Very High Very High Very High
Disease 131 97.96 Very High Very High Very High
Pain 15 92.88 High High
Syndrome 107 92.64 High High
Mouth Disease 22 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examples are (i) a picomolar inhibitor of Respiratory Syncytial Virus F protein mediated fusion with host cells, (ii) a nanomolar inhibitor of RNA binding to the transporter protein HIV-Rev, (iii) a submicromolar inhibitor of Streptococcus pneumoniae growth induced by quorum sensing pheromone Competence Stimulating Peptide, and (iv) a picomolar agonist of the GPCR pain receptor opioid receptor like receptor ORL-1.
transporter protein HIV-Rev Spec (like) Binding (binding) of in Respiratory associated with pain, bacterial meningitis, acquired immune deficiency syndrome or hiv infection, agonist, opioid receptor and respiratory syncytial virus
1) Confidence 0.10 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20543141 Disease Relevance 0.39 Pain Relevance 0.26
They first associate with a Rab escort protein (REP) and form a stable complex that is the substrate for the subsequent dual prenylation of C-terminal cysteine motifs via Rab geranylgeranyl transferase (RabGGT).
Rab Binding (associate) of
2) Confidence 0.10 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.07 Pain Relevance 0
The ability of Rabs to perform these different tasks in a co-ordinated and regulated manner originates in their highly dynamic conformation and mobility and from their interaction with different Rab-associated proteins, as illustrated in the Rab GTPase cycle (Fig. 1).
Rab Binding (interaction) of
3) Confidence 0.10 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.06 Pain Relevance 0
The potent nitrogen-containing biphosphonates, such as pamidronate, alendronate, ibandronate and zoledronate, inhibit a key enzyme, farnesyl pyrophosphate synthase, which is necessary for Rab activity, hence their inhibitory action on osteoclast activity [29].
Rab Binding (activity) of in osteoclast
4) Confidence 0.08 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.08 Pain Relevance 0
More than 60 human Rab proteins have been identified, and their function has been shown to depend on their interaction with different Rab-associated proteins regulating Rab activation, post-translational modification and intracellular localization.
Rab Binding (interaction) of
5) Confidence 0.07 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 0.19 Pain Relevance 0
Rab proteins must not only be bound to GTP, but they need also to be ‘prenylated’—i.e. bound to the cell membranes by isoprenes, which are intermediaries in the synthesis of cholesterol (e.g. geranyl geranyl or farnesyl compounds).
Rab Binding (bound) of
6) Confidence 0.07 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 1.74 Pain Relevance 0.09
Enfuvirtide acts by binding to a region of the HIV-1 gp41 envelope protein, resulting in its inhibition, and thereby inhibits the steps which lead to fusion of the viral envelope and the cell membrane.22 Due to its unique mechanism of activity, enfuvirtide maintains activity against isolates resistant to other ARV classes.
HIV-1 gp41 envelope protein Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 0.60 Pain Relevance 0
Normally, GDP is tightly bound by Rab GTPases, and the low intrinsic rate of GDP dissociation makes GDP release the rate-limiting step of nucleotide exchange and Rab activation.
Rab Binding (bound) of
8) Confidence 0.05 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.30 Pain Relevance 0
The binding of warfarin, a series of non-steroidal anti-inflammatory drugs and a series of benzodiazepines to rat serum albumin (RatSA) and rabbit serum albumin (RabSA) was compared with their binding to human serum albumin (HSA) using high-performance liquid chromatography on stationary phases based on immobilized albumins.
RabSA Binding (binding) of associated with inflammation and cinod
9) Confidence 0.01 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 8838677 Disease Relevance 0.10 Pain Relevance 0.10

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