INT64977

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.54
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TFF3) proteinaceous extracellular matrix (TFF3) molecular_function (TFF3)
Anatomy Link Frequency
duodenum 1
goblet cells 1
TFF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 97.48 Very High Very High Very High
Inflammation 60 86.96 High High
Bioavailability 1 86.40 High High
cytokine 1 85.92 High High
aspirin 76 84.52 Quite High
abdominal pain 2 46.56 Quite Low
headache 2 38.08 Quite Low
Neuropeptide 1 25.00 Low Low
depression 2 16.56 Low Low
Neuropathic pain 2 15.60 Low Low
Disease Link Frequency Relevance Heat
Cancer 211 98.36 Very High Very High Very High
Disease 26 97.20 Very High Very High Very High
Ulcers 13 97.20 Very High Very High Very High
INFLAMMATION 63 86.96 High High
Arrhythmias 2 Under Development 5 83.12 Quite High
Breast Cancer 48 82.84 Quite High
Vomiting 29 79.64 Quite High
Fatigue 18 79.08 Quite High
Diarrhoea 6 78.40 Quite High
Thrombocytopenia 9 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three trefoil peptides are expressed constitutively by epithelial cells in specific regions of the GI tract: pS2 (gastric), spasmolytic polypeptide (SP, gastric and Brunner's glands), and intestinal trefoil factor (ITF, goblet cells).
Gene_expression (expressed) of ITF in goblet cells
1) Confidence 0.75 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479633 Disease Relevance 0.16 Pain Relevance 0.10
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Gene_expression (expression) of TFF3 gene associated with cancer
2) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.94 Pain Relevance 0
ITF2357 is a synthesized HDAC inhibitor containing a hydroxamic acid moiety linked to an aromatic ring.
Gene_expression (synthesized) of ITF
3) Confidence 0.58 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.44 Pain Relevance 0.13
GATA3, ESR1, TFF1, TFF3 and ERBB4 were upregulated, whereas IGF2R, GATA6, EGFR and TGFA were downregulated in ER+ ERBB2-amplified tumors.
Gene_expression (upregulated) of TFF3 associated with cancer
4) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.81 Pain Relevance 0
The third group of eight subjects received, in ascending order, four dose levels of ITF 296 (10, 20, 40, 80 micrograms/kg) by 1-min i.v. injection.
Gene_expression (levels) of ITF
5) Confidence 0.51 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8839230 Disease Relevance 0.06 Pain Relevance 0
The first two groups (six subjects each) received, in ascending order, three dose levels of ITF 296 by 30-min intravenous infusion (group I, 0.1, 0.5, 1.0 microgram/kg/min; group II, 2.0, 4.0, 6.0 micrograms/kg/min).
Gene_expression (levels) of ITF
6) Confidence 0.51 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8839230 Disease Relevance 0 Pain Relevance 0
RESULTS: Relative expression level of TFF1, TFF2, TFF3 mRNA was 616: 12: 1 in unstimulated MKN45 cells.
Gene_expression (expression) of TFF3 mRNA
7) Confidence 0.27 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15298624 Disease Relevance 0 Pain Relevance 0
Although indometacin (1-250 micro mol/L) had no significant effect on the expression of TFF1 and TFF3 mRNA, it up-regulated TFF2 mRNA expression in a dose- and time-dependent manner.
Gene_expression (expression) of TFF3 mRNA
8) Confidence 0.27 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15298624 Disease Relevance 0 Pain Relevance 0
TFF1, TFF2, and TFF3 mRNA expression was assessed by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (expression) of TFF3 mRNA
9) Confidence 0.27 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15298624 Disease Relevance 0 Pain Relevance 0
Trefoil factor family 1 (TFF1)and TFF2 are expressed in the stomach and TFF2 and TFF3 are expressed in the duodenum.
Gene_expression (expressed) of TFF3 in duodenum
10) Confidence 0.21 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682452 Disease Relevance 0.13 Pain Relevance 0.17

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