INT64980

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Context Info
Confidence 0.05
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
platelet 4
Ptafr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 100.00 Very High Very High Very High
chemokine 1 97.80 Very High Very High Very High
cytokine 19 96.92 Very High Very High Very High
Paracetamol 1 90.92 High High
Inflammatory response 2 89.76 High High
Inflammation 34 88.20 High High
cINOD 3 76.24 Quite High
ketamine 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 39 100.00 Very High Very High Very High
Inflammatory Bowel Disease 22 99.78 Very High Very High Very High
Cancer 2 99.76 Very High Very High Very High
Necrosis 1 99.52 Very High Very High Very High
Disease 11 95.12 Very High Very High Very High
Genetic Predisposition To Disease 1 94.08 High High
Injury 7 92.56 High High
Edema 1 81.84 Quite High
Hepatotoxicity 4 78.72 Quite High
Colon Cancer 4 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mononuclear phagocytes, as well as hepatic endothelial cells and stellate cells, are activated to release increased amounts of proinflammatory and cytotoxic mediators including hydrogen peroxide, superoxide anion, nitric oxide, bioactive lipids, interleukin 1, platelet activating factor, and tumor necrosis factor alpha.
Positive_regulation (increased) of Localization (release) of platelet activating factor in platelet associated with necrosis and cancer
1) Confidence 0.05 Published 1996 Journal Toxicol Pathol Section Abstract Doc Link 8839288 Disease Relevance 0.60 Pain Relevance 0.17
In IBD, there is increased synthesis and release of pro-inflammatory mediators, such as eicosanoids, platelet activating factor, reactive oxygen species (ROS), nitrogen metabolites, chemokines and mainly cytokines [5] that have been associated with disease severity, activity and remission [2].
Positive_regulation (increased) of Localization (release) of platelet activating factor in platelet associated with chemokine, inflammatory bowel disease, inflammatory mediators, disease and cytokine
2) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2909993 Disease Relevance 1.76 Pain Relevance 0.38

General Comments

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