INT6499

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Context Info
Confidence 0.79
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 44
Total Number 45
Disease Relevance 11.78
Pain Relevance 8.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
neurons 4
macrophages 2
hindlimb 2
hepatocytes 2
neuronal 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 133 100.00 Very High Very High Very High
substance P 109 100.00 Very High Very High Very High
cytokine 100 100.00 Very High Very High Very High
Enkephalin 22 100.00 Very High Very High Very High
Nucleus accumbens 14 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Catecholamine 2 100.00 Very High Very High Very High
Paracetamol 14 99.98 Very High Very High Very High
Inflammation 95 99.60 Very High Very High Very High
substantia gelatinosa 4 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 26 100.00 Very High Very High Very High
INFLAMMATION 165 99.60 Very High Very High Very High
Autoimmune Disease 6 99.52 Very High Very High Very High
Diabetic Neuropathy 54 99.26 Very High Very High Very High
Injury 327 99.12 Very High Very High Very High
Hypoxia 128 99.12 Very High Very High Very High
Cirrhosis 25 98.28 Very High Very High Very High
Neurodegenerative Disease 18 97.96 Very High Very High Very High
Disease 44 97.80 Very High Very High Very High
Neuroblastoma 12 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is the first ultrastructural description of fl-trkB localization at synapses between first- and second-order sensory neurons in lamina II, and suggests that BDNF may be released by fl-trkB-immunopositive PAFs to modulate nociceptive input in this lamina of dorsal horn.
Localization (localization) of trkB in synapses associated with nociception, primary afferent fibers and dorsal horn
1) Confidence 0.79 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262634 Disease Relevance 0.39 Pain Relevance 0.54
Ultrastructural evidence for a pre- and postsynaptic localization of full-length trkB receptors in substantia gelatinosa (lamina II) of rat and mouse spinal cord.
Localization (localization) of trkB in substantia gelatinosa associated with substantia gelatinosa and spinal cord
2) Confidence 0.79 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16262634 Disease Relevance 0.39 Pain Relevance 0.55
Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine.
Localization (co-localized) of Tyrosine kinase B in neuronal associated with nucleus accumbens, enkephalin and cocaine
3) Confidence 0.74 Published 2003 Journal Neuroscience Section Title Doc Link 12605901 Disease Relevance 0 Pain Relevance 1.18
Another study has reported that BDNF- and TrkB-immunoreactive neurons increase following peripheral injury [31].
Localization (increase) of TrkB-immunoreactive in neurons associated with nerve growth factor and injury
4) Confidence 0.49 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.54 Pain Relevance 0.46
Double labeling for SP, NK1-R, BDNF, TrkB, or ATF3 and Protein-gene product 9.5 (PGP-9.5), a marker for neurons, was performed as follows.
Localization (Double) of TrkB in neurons associated with nerve growth factor and substance p
5) Confidence 0.49 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790972 Disease Relevance 0.28 Pain Relevance 0.40
Schwann cells and vascular macrophages within peripheral nerve grafts secrete a variety of neurotrophic and growth factors as well as extracellular matrix molecules that are both neuroprotective and support continued axonal growth [50].
Localization (secrete) of factors in macrophages
6) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.23 Pain Relevance 0.12
Results indicate that tyrosine kinase B and C receptors are co-localized in both enkephalin-positive and enkephalin-negative neurons in both of these nuclei, which suggests that these receptors influence both the striatal-pallidal (enkephalin) and striatal-ventral mesencephalic (substance P/dynorphin) pathways.
Localization (localized) of tyrosine kinase B in ventral associated with dynorphin, enkephalin and substance p
7) Confidence 0.35 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605901 Disease Relevance 0 Pain Relevance 0.95
Although many examples exist in the literature concerning P2Y nucleotide receptors interacting with neurotrophins [31], our results with P2X7 receptors in granule neurons give evidence that releasing mechanisms or TrkB transactivating effects are not contributing to the observed BzATP-mediated neuroprotection.
Localization (releasing) of TrkB in neurons
8) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.06
Many of the NMDA protective actions are attributed to BDNF secretion, which then activates TrkB receptors on this neuron itself or on surrounding neurons to elicit survival responses.
Localization (secretion) of TrkB in neurons
9) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
However, a minority of NK1 receptors in the urinary bladder were lost after capsaicin, indicating that these receptors are located on sensory terminals, or may be dependent on growth factors or other chemicals released from these nerves.
Localization (released) of factors in urinary bladder associated with qutenza
10) Confidence 0.28 Published 1992 Journal Peptides Section Abstract Doc Link 1329047 Disease Relevance 0 Pain Relevance 0.43
Chromaffin cells from the adrenal gland secrete a combination of neuroactive compounds including catecholamines, opioid peptides, and growth factors that have strong analgesic effects, especially when administered intrathecally.
Localization (secrete) of factors in adrenal gland associated with analgesic, catecholamine and opioid
11) Confidence 0.09 Published 2005 Journal Cell Transplant Section Abstract Doc Link 16180654 Disease Relevance 0.06 Pain Relevance 0.59
Chemotactic factors released from hepatocytes exposed to acetaminophen.
Localization (released) of factors in hepatocytes associated with paracetamol
12) Confidence 0.05 Published 1995 Journal Dig. Dis. Sci. Section Title Doc Link 7648987 Disease Relevance 0.09 Pain Relevance 0.55
These results suggest that hepatocytes exposed to acetaminophen release two types of chemotactic factors for neutrophils and that a major part of the chemotactic factor could be different from a member of interleukin-8 family.
Localization (release) of factors in hepatocytes associated with paracetamol
13) Confidence 0.05 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7648987 Disease Relevance 0.05 Pain Relevance 0.55
Measures of background factors
Localization (Measures) of factors
14) Confidence 0.05 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0 Pain Relevance 0
The fact that variations in psychological distress between practice areas were also seen after adjustments for specific work factors suggests that there are unmeasured work factors of importance, or differential selection into jobs in different practice areas.
Localization (unmeasured) of factors
15) Confidence 0.05 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0.15 Pain Relevance 0
At baseline, a series of factors related to the private sphere were recorded, including age (five-year cohorts), gender, marital status (single vs. married or cohabiting), number of preschool children (0; 1; 2; 3 or more), current pregnancy, and special tasks of care taking during the leisure time, such as caring for handicapped child or old relatives (no; a little; rather much; very much).
Localization (series) of factors
16) Confidence 0.05 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0 Pain Relevance 0
The development of a scaffold able to mimic the mechanical properties of elastic tissues and to induce local angiogenesis by controlled release of angiogenic growth factors could be applied in the treatment of several ischemic diseases.
Localization (release) of factors in elastic tissues associated with disease
17) Confidence 0.03 Published 2010 Journal Biomaterials Section Abstract Doc Link 20381861 Disease Relevance 0.10 Pain Relevance 0.08
Neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4, are a family of secreted growth factors that promote the survival, differentiation and maintenance of specific neuronal populations and regulate activity-dependent synaptic plasticity (reviewed in Bibel and Barde, 2000).
Localization (secreted) of factors in brain associated with nerve growth factor
18) Confidence 0.02 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.57 Pain Relevance 0.31
We used SH-SY5Y cells to evaluate whether SC-like cells could secrete soluble factors since genuine SC can induce the differentiation of SH-SY5Y neuroblastoma cells efficiently through production of soluble factors [19].
Localization (secrete) of factors in SH-SY5Y associated with neuroblastoma
19) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.10 Pain Relevance 0
We showed further that SC-like cells were functional since these cells could secrete soluble factors and form myelin structures with neuronal neurites.
Localization (secrete) of factors in neurites
20) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.18 Pain Relevance 0

General Comments

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