INT650

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 7.44
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Afp) extracellular space (Afp) extracellular region (Afp)
cytoplasm (Afp)
Anatomy Link Frequency
liver 6
embryos 1
capillary 1
Afp (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 11 97.88 Very High Very High Very High
fibrosis 4 96.24 Very High Very High Very High
Paracetamol 8 96.16 Very High Very High Very High
imagery 49 95.68 Very High Very High Very High
Dopamine 2 95.44 Very High Very High Very High
Inflammation 23 94.36 High High
noradrenaline 2 93.48 High High
headache 2 85.40 High High
positron emission tomography 74 77.36 Quite High
alcohol 4 64.64 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 201 99.84 Very High Very High Very High
Immunodeficiency 5 99.52 Very High Very High Very High
Cancer 192 99.28 Very High Very High Very High
Telangiectasia 31 98.72 Very High Very High Very High
Hepatitis 11 98.12 Very High Very High Very High
Disease 18 97.48 Very High Very High Very High
Poisoning 4 96.56 Very High Very High Very High
Fibrosis 2 96.24 Very High Very High Very High
Cirrhosis 15 96.00 Very High Very High Very High
INFLAMMATION 23 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possible role of liver plate structure in the regulation of AFP synthesis is discussed.
Gene_expression (synthesis) of AFP in liver
1) Confidence 0.78 Published 1983 Journal Int. J. Cancer Section Abstract Doc Link 6190767 Disease Relevance 0 Pain Relevance 0.08
Alpha-fetoprotein synthesis in relation to structural peculiarities in postnatal and regenerating mouse liver.
Gene_expression (synthesis) of Alpha-fetoprotein in liver
2) Confidence 0.78 Published 1983 Journal Int. J. Cancer Section Title Doc Link 6190767 Disease Relevance 0 Pain Relevance 0.13
[Liver structure as a possible factor in the regulation of alpha-fetoprotein synthesis].
Gene_expression (synthesis) of alpha-fetoprotein in Liver
3) Confidence 0.78 Published 1979 Journal Biull Eksp Biol Med Section Title Doc Link 88968 Disease Relevance 0.09 Pain Relevance 0.18
When we monitored gene expression levels of AFP by real-time PCR in KO and WT, there was no significant difference between WT (n = 3) and KO (n = 3) embryos (Figure 4A).
Gene_expression (expression) of AFP in embryos
4) Confidence 0.77 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0 Pain Relevance 0
The reappearance of Ag I on the surface of liver cells coincides with cessation of AFP synthesis and establishment of definitive plate structure.
Gene_expression (synthesis) of AFP in liver
5) Confidence 0.60 Published 1983 Journal Int. J. Cancer Section Abstract Doc Link 6190767 Disease Relevance 0 Pain Relevance 0.14
Both in the liver regeneration and early postnatal ontogenesis the cessation of the AFP synthesis in hepatocytes coincides with the appearance of the bile capillary antigen on the cell surface.
Gene_expression (synthesis) of AFP in capillary associated with bile
6) Confidence 0.60 Published 1979 Journal Biull Eksp Biol Med Section Abstract Doc Link 88968 Disease Relevance 0.10 Pain Relevance 0.19
Currently, alpha-fetoprotein (AFP) is the only serological marker that is available for the detection of HCC clinically.
Gene_expression (detection) of AFP associated with hepatocellular cancer
7) Confidence 0.54 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 1.07 Pain Relevance 0.04
[Characteristics of hepatocytes containing alpha-fetoprotein in regenerating mouse liver].
Gene_expression (containing) of alpha-fetoprotein in liver
8) Confidence 0.52 Published 1977 Journal Biull Eksp Biol Med Section Title Doc Link 70250 Disease Relevance 0.23 Pain Relevance 0.10
In a study by Giannelli et al. [34], only a small percentage of patients showed AFP values that are reflective of HCC.
Gene_expression (reflective) of AFP associated with hepatocellular cancer
9) Confidence 0.47 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.92 Pain Relevance 0.10
Older mice develop multiple cancer nodules characterized by increased expression of fetal liver genes including alpha-fetoprotein.
Gene_expression (expression) of alpha-fetoprotein in liver associated with cancer
10) Confidence 0.32 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.43 Pain Relevance 0.15
Alpha fetoprotein was found in the serum of 55 per cent of nine patients tested.
Gene_expression (found) of Alpha fetoprotein
11) Confidence 0.11 Published 1975 Journal Surg Gynecol Obstet Section Abstract Doc Link 174234 Disease Relevance 0.93 Pain Relevance 0.06
Regarding tumor markers, carbohydrate antigen 19-9, carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) were all negative.
Neg (negative) Gene_expression (negative) of alpha fetoprotein associated with cancer
12) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2777156 Disease Relevance 1.03 Pain Relevance 0.32
Serum levels of alpha fetoprotein (AFP) are usually increased in A-T patients [4-6].
Gene_expression (levels) of alpha fetoprotein associated with telangiectasia
13) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2662841 Disease Relevance 1.64 Pain Relevance 0

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