INT65000

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1996
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.69
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr2c) nucleus (Htr2c) cytoplasm (Htr2c)
signal transducer activity (Htr2c)
Anatomy Link Frequency
neurons 2
choroid plexus 2
lobe 2
Htr2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 16 99.76 Very High Very High Very High
antidepressant 4 99.70 Very High Very High Very High
sSRI 28 99.38 Very High Very High Very High
gABA 9 99.00 Very High Very High Very High
agonist 7 96.32 Very High Very High Very High
Serotonin 13 95.20 Very High Very High Very High
withdrawal 3 91.04 High High
antagonist 9 90.48 High High
Eae 1 84.56 Quite High
tetrodotoxin 1 79.16 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 18 96.44 Very High Very High Very High
Premature Ejaculation 106 95.28 Very High Very High Very High
Reprotox - General 2 11 75.64 Quite High
Depression 1 65.44 Quite High
Vomiting 12 46.24 Quite Low
Dizziness 4 30.28 Quite Low
Diarrhoea 4 29.68 Quite Low
Headache 5 29.28 Quite Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Hypoactive Sexual Desire Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the results show that chronic citalopram and fluoxetine treatments induce an increase of choroid plexus 5-HT2C receptor density, but the effect is more marked with citalopram.
Positive_regulation (induce) of Positive_regulation (increase) of 5-HT2C in choroid plexus associated with fluoxetine
1) Confidence 0.67 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8840350 Disease Relevance 0 Pain Relevance 0.76
The second is likely to arise from axon collaterals of SNr neurons themselves and is facilitated by an increase in firing via postsynaptic, somatodendritic 5-HT2C receptor activation, but it is depressed by GABA(B) receptor activation.
Positive_regulation (increase) of Positive_regulation (activation) of 5-HT2C in neurons associated with gaba
2) Confidence 0.49 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8922413 Disease Relevance 0.07 Pain Relevance 0.79
These results suggest that increased anxiety in rodents, and possibly, also in humans (e.g. agitation or jitteriness after SSRIs and panic after m-CPP), caused by acute administration of SSRI antidepressants or m-CPP, are mediated by activation of 5-HT2C receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of 5-HT2C associated with antidepressant, anxiety disorder and ssri
3) Confidence 0.49 Published 2001 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 11806866 Disease Relevance 0.40 Pain Relevance 0.76
It is concluded that 5-HT via activation of 5-HT1A, 5-HT2A, 5-HT2C and possibly also 5-HT1B receptors increases the synthesis of CRH in the PVN and POMC in the anterior pituitary lobe, which results in increased ACTH secretion.
Spec (possibly) Positive_regulation (increases) of Spec (possibly) Positive_regulation (activation) of 5-HT2C in lobe
4) Confidence 0.49 Published 2002 Journal J. Neuroendocrinol. Section Abstract Doc Link 12372003 Disease Relevance 0 Pain Relevance 0.31
Several in vitro and animal studies have demonstrated that the desensitization of 5-HT1A receptors, increased activation of postsynaptic 5-HT2C receptors, and the resultant higher increase in synaptic 5-HT neurotransmission seen in daily dosing of SSRI class drugs can be acutely achieved by blockade of these receptors by administration of an on-demand SSRI and a 5-HT1A receptor antagonist (Cremers et al 2000; Williamson et al 2003; de Jong et al 2005).
Positive_regulation (increased) of Positive_regulation (activation) of 5-HT2C associated with antagonist and ssri
5) Confidence 0.45 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671940 Disease Relevance 0.22 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox