INT65007

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Context Info
Confidence 0.03
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.48

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mitochondrion (CTSA) small molecule metabolic process (CTSA) lyase activity (DAK)
endoplasmic reticulum (CTSA) cytosol (DAK) peptidase activity (CTSA)
DAK (Homo sapiens)
CTSA (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.48 Very High Very High Very High
diclofenac 1 95.92 Very High Very High Very High
rheumatoid arthritis 1 86.28 High High
metalloproteinase 1 82.88 Quite High
aspirin 1 75.60 Quite High
dexamethasone 1 73.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 98.76 Very High Very High Very High
Rheumatoid Arthritis 1 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eglin C and the glycosaminoglycan-peptide complex DAK-16, at concentrations ranging from 10(-9) to 10(-4) M, dose-dependently inhibited elastase and cathepsin G while the nonsteroidal anti-inflammatory drugs oxyphenbutazone, phenylbutazone, sulfinpyrazone and diclofenac-Na required high concentrations to demonstrate some inhibitory effects on the activity of both enzymes.
DAK-16 Negative_regulation (inhibited) of cathepsin associated with inflammation, cinod and diclofenac
1) Confidence 0.03 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8841833 Disease Relevance 0.35 Pain Relevance 0.48

General Comments

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