INT65011

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Context Info
Confidence 0.08
First Reported 1996
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.92
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) plasma membrane (PTGER2)
Anatomy Link Frequency
HGF 3
IL1B (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 3 94.80 High High
cINOD 6 94.08 High High
cytokine 16 93.72 High High
Inflammation 21 89.52 High High
metalloproteinase 6 26.28 Quite Low
COX2 3 25.00 Low Low
cOX1 1 25.00 Low Low
chemokine 11 17.28 Low Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Periodontal Disease 2 95.72 Very High Very High Very High
INFLAMMATION 27 94.40 High High
Ulcers 2 78.76 Quite High
Adhesions 2 67.64 Quite High
Death 6 63.72 Quite High
Cancer 4 53.64 Quite High
Disease 8 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.
IL-1 Positive_regulation (induced) of PGE2 in HGF
1) Confidence 0.08 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.23 Pain Relevance 0.36
Therefore, the purpose of this study was to determine if PGE2 induced by IL-1 beta could potentiate the IL-6 response by HGF.
IL-1 beta Positive_regulation (induced) of PGE2 in HGF
2) Confidence 0.08 Published 1996 Journal J. Clin. Periodontol. Section Abstract Doc Link 8841895 Disease Relevance 0.15 Pain Relevance 0.19
These results suggest the endogenous PGE2 induced by IL-1 beta plays an important regulatory role in IL 6 production by HGF.
IL-1 beta Positive_regulation (induced) of PGE2 in HGF
3) Confidence 0.08 Published 1996 Journal J. Clin. Periodontol. Section Abstract Doc Link 8841895 Disease Relevance 0.16 Pain Relevance 0.23
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
IL-1 Positive_regulation (induced) of PGE2
4) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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