INT65025

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4)
plasma membrane (Oprm1) lysosome (Hps4) cytoplasm (Hps4)
Anatomy Link Frequency
dendrites 1
neurons 1
Oprm1 (Mus musculus)
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 26 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
Morphine 2 94.12 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leu5-enkephalin (LE), a potential endogenous ligand for MOR, is also present within neurons in this region.
MOR Binding (ligand) of LE in neurons associated with mu opioid receptor and enkephalin
1) Confidence 0.01 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8841907 Disease Relevance 0 Pain Relevance 0.93
We conclude that MOR ligands, possibly including LE, can act at extrasynaptic MORs on the plasma membranes of axons and dendrites in the caudal NTS to modulate the presynaptic release and postsynaptic responses of neurons.
MOR Binding (ligands) of LE in dendrites associated with mu opioid receptor and enkephalin
2) Confidence 0.01 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8841907 Disease Relevance 0 Pain Relevance 1.00

General Comments

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