INT65033
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
These results suggest that endogenous astroglial FGF-2 contributes to maintaining NP tactile allodynia associated with reactivity of spinal cord astrocytes and that inhibition of spinal FGF-2 ameliorates NP pain signs. | |||||||||||||||
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By 24 h, 3 months and 6 months after PTCA, bFGF levels had decreased significantly in the PTCA group (3.2+/-0.6, 1.7+/-0.3 and 2.7+/-0.6 pg/ml, respectively, P<0.05). | |||||||||||||||
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Following PTCA, bFGF levels decreased significantly and remained stable for 6 months after the procedure. | |||||||||||||||
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Axotomy also elevated the number of GFAP astrocytes (143% after crush; 277% after transection) and nuclear FGF-2 (57% after transection) in astrocytes (confirmed by two-color immunoperoxidase) in the ipsilateral facial nucleus. | |||||||||||||||
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Recombinant VS was shown to inhibit basic fibroblast growth factor (bFGF) and VEGF-induced endothelial cell proliferation in vitro [17]. | |||||||||||||||
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This study was aimed to compare the effects of selective Cox-2 inhibitor (NS398) versus non-selective Cox inhibitor (indomethacin) on basal and basic fibroblast growth factor (bFGF) - stimulated gastric wound re-epithelialization. | |||||||||||||||
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This study was aimed to compare the effects of selective Cox-2 inhibitor (NS398) versus non-selective Cox inhibitor (indomethacin) on basal and basic fibroblast growth factor (bFGF) - stimulated gastric wound re-epithelialization. | |||||||||||||||
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These findings indicate that specific Cox-2 inhibitor (NS398) does not interfere with the basal re-epithelialization but significantly inhibits the bFGF - stimulated re-epithelialization, whereas indomethacin interferes with both the basal as well as the bFGF-stimulated wound re-epithelialization. | |||||||||||||||
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Both indomethacin and NS398 inhibited bFGF stimulated wound re-epithelialization, with indomethacin having a greater inhibitory effect. | |||||||||||||||
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Our data agree with a previous report of upregulated Fgf2 protein levels after 3 months of diabetes in the Sprague Dawley rat [54]. | |||||||||||||||
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Recombinant VS was shown to inhibit basic fibroblast growth factor (bFGF) and VEGF-induced endothelial cell proliferation in vitro [17]. | |||||||||||||||
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Recombinant VS was shown to inhibit bFGF- and VEGF-induced endothelial cell proliferation in vitro [17]. | |||||||||||||||
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and bFGF were decreased by 63%, 77% and 63%, respectively, in rats treated with 30 mg/kg/day of pioglitazone (Table 4). | |||||||||||||||
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Local action: Plantar subcutaneous injection of bFGF at above 0.005 mg/site induced edema by itself on and after the next day, and also reinforced carrageenin-induced edema from 1 day after injection. | |||||||||||||||
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By contrast, NSAIDs, cyclooxygenase-2 (COX-2) inhibitors, and alendronate have been shown to delay the healing of ulcers, and impair angiogenesis and the down regulation of growth factors such as bFGF and VEGF (17-19). | |||||||||||||||
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In a phase II clinical trial for advanced renal cell carcinoma, patients rendered copper deficient with TM therapy had a significantly decreased serum content of proangiogenic mediators, VEGF, FGF-2, IL-6, and IL-8 [29]. | |||||||||||||||
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Treatments (Dll4 and Ang2, 500 ng/ml; FGF2, 20 ng/ml; JAK inhibitor, 200 nM) were every 2 days.
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Immunohistochemical analysis was used to define the different hormone types of the tumors and the expression of various immunologic targets, including the pituitary tumor transforming gene, basic fibroblast growth factor-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and proliferating cell nuclear antigen. | |||||||||||||||
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Overall, the most beneficial growth factor was bFGF, which was most potent in increasing proliferation and GAG synthesis, and also effective in promoting collagen synthesis. | |||||||||||||||
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Plasma concentrations of VEGF were similar (p=0.151) at the different time points after exercise but FGF-2 levels decreased (p=0.013). | |||||||||||||||
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