INT65053

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.78
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
retina 2
HeLa 2
nucleus 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.40 Very High Very High Very High
aspirin 5 98.50 Very High Very High Very High
metalloproteinase 5 97.98 Very High Very High Very High
Inflammation 63 97.44 Very High Very High Very High
cerebral cortex 2 96.88 Very High Very High Very High
narcan 4 96.68 Very High Very High Very High
Spinal cord 5 92.40 High High
dexamethasone 3 91.56 High High
MU agonist 4 90.72 High High
withdrawal 2 89.60 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 99.82 Very High Very High Very High
Hypoxia 17 99.24 Very High Very High Very High
INFLAMMATION 66 97.44 Very High Very High Very High
Ganglion Cysts 4 96.00 Very High Very High Very High
Hyperglycemia 1 90.72 High High
Death 28 87.28 High High
Nasopharynx Cancer 4 86.12 High High
Stress 20 81.96 Quite High
Cancer 96 79.40 Quite High
Toxicity 2 78.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: HeLa cells pretreated with indomethacin showed a decrease in the temperature-time combination necessary to inhibit IR-induction of NF-kappaB DNA binding.
Positive_regulation (induction) of NF-kappaB Binding (binding) of in HeLa
1) Confidence 0.65 Published 2002 Journal Int. J. Radiat. Biol. Section Body Doc Link 12065054 Disease Relevance 0 Pain Relevance 0
Oral aspirin (as a representative of the salicylate family) inhibited diabetes-induced increase in NF-kappaB DNA-binding affinity in electrophoretic mobility shift assay and transcription factor array in nuclear extract isolated from whole retina.
Positive_regulation (increase) of NF-kappaB Binding (affinity) of in retina associated with aspirin and diabetes mellitus
2) Confidence 0.55 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.37 Pain Relevance 0.27
The DNA binding activity of NF kappa B was increased compared with the hypoxic group.
Positive_regulation (increased) of NF kappa B Binding (activity) of associated with hypoxia
3) Confidence 0.46 Published 2000 Journal Int J Tissue React Section Abstract Doc Link 11199341 Disease Relevance 0.56 Pain Relevance 0.07
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
Positive_regulation (induced) of NF-kB Binding (activity) of in nucleus associated with spinal cord
4) Confidence 0.45 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.43 Pain Relevance 0.50
Thus, similar concentrations of indomethacin both lowered the threshold thermal exposure to inhibit activation of NF-kappaB DNA-binding and increased the sensitivity of tumour cells to hyperthermic radiosensitization-induced cytotoxicity.
Positive_regulation (activation) of NF-kappaB Binding (binding) of
5) Confidence 0.44 Published 2002 Journal Int. J. Radiat. Biol. Section Body Doc Link 12065054 Disease Relevance 0 Pain Relevance 0
Acute (2 h, 4 h) and long-term (72 h) treatment with DAMGO time-dependently increased the DNA-binding activity of both AP-1 and NF-kappa B and the stimulation could be abolished or inhibited by concurrent incubation with naloxone.
Positive_regulation (increased) of NF-kappa B Binding (activity) of associated with narcan
6) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.39
Acute (2 h, 4 h) and long-term (72 h) treatment with DAMGO time-dependently increased the DNA-binding activity of both AP-1 and NF-kappa B and the stimulation could be abolished or inhibited by concurrent incubation with naloxone.
Positive_regulation (increased) of NF-kappa B Binding (binding) of associated with narcan
7) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.39
In the same experiments, extracellular nucleotides also increased DNA binding of nuclear factor kappa B (NF-kB), another transcriptional factor crucially involved in several inflammatory events including reactive astrogliosis.
Positive_regulation (increased) of NF-kB Binding (binding) of associated with inflammation
8) Confidence 0.17 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.16 Pain Relevance 0.07
The temporal profile of AP-1- and NF-kB-induced DNA binding, which was significantly increased 30 min after nucleotide addition to cultures and reached a maximal peak at 1 h, was consistent with the timing of ERK1/2 activation, the latter already being maximally activated after a 10-min exposure to purine analogs [51].
Positive_regulation (increased) of NF-kB Binding (binding) of
9) Confidence 0.11 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.15 Pain Relevance 0.05
We have found that APAP inhibits serum growth factor activation of c-myc expression, NF-kappaB DNA binding, and Raf kinase.
Positive_regulation (activation) of NF-kappaB Binding (binding) of associated with paracetamol
10) Confidence 0.07 Published 1999 Journal Toxicol. Sci. Section Abstract Doc Link 10353317 Disease Relevance 0.24 Pain Relevance 1.00
It was postulated that the observed down-regulation of matrix metalloproteinase-9 was due to inhibition of granulocytemacrophage colonystimulating factor (GM-CSF) production which resulted in decreased binding activity of NF-kB and AP-1 transcription factors.
Positive_regulation (resulted) of NF-kB Binding (binding) of associated with metalloproteinase
11) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.87 Pain Relevance 0.09

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