INT65054

Context Info Confidence 0.70 First Reported 1995 Last Reported 2010 Negated 3 Speculated 15 Reported most in Abstract Documents 285 Total Number 300 Disease Relevance 149.33 Pain Relevance 126.73

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1) cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)

Anatomy Link Frequency nucleus 12 PBMC 9 spinal cord 9 monocytes 8 brain 5 Nfkb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 924 100.00 Neuropathic pain 198 100.00 Inflammatory mediators 44 100.00 Nerve growth factor 18 100.00 nMDA receptor 18 100.00 Spinal cord 135 99.98 Paracetamol 54 99.98 antidepressant 27 99.98 MU agonist 12 99.98 cytokine 492 99.96

Disease Link Frequency Relevance Heat INFLAMMATION 1087 100.00 Neuropathic Pain 284 100.00 Myocardial Infarction 29 100.00 Injury 330 99.96 Adhesions 82 99.92 Pneumonia 14 99.92 Apoptosis 289 99.90 Alzheimer's Dementia 35 99.84 Neuroblastoma 19 99.84 Experimental Autoimmune Neuritis 10 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, this compound reduces the increased NF-kappaB binding activity, which occurs in these degenerative conditions.

Positive_regulation (increased) of NF-kappaB

1) Confidence 0.70 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11918971 Disease Relevance 1.22 Pain Relevance 0.62

Moreover, activation of NF-kappaB by amyloid-derived peptides was greatly impaired by acetaminophen pre-treatment in hippocampal cells.

Positive_regulation (activation) of NF-kappaB associated with paracetamol and alzheimer's dementia

2) Confidence 0.70 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 11918971 Disease Relevance 1.30 Pain Relevance 0.73

Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.

Positive_regulation (activation) of NF-kappaB associated with pregabalin, neuroblastoma, gabapentin, glioma and substance p

3) Confidence 0.70 Published 2008 Journal J. Cell. Biochem. Section Title Doc Link 18615578 Disease Relevance 0.47 Pain Relevance 1.21

Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in these cells.

Positive_regulation (activation) of NF-kappaB associated with pregabalin, gabapentin and substance p

4) Confidence 0.70 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 18615578 Disease Relevance 0.44 Pain Relevance 1.14

In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells.

Spec (investigated) Positive_regulation (activation) of NF-kappaB associated with neuroblastoma, glioma and substance p

5) Confidence 0.70 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 18615578 Disease Relevance 0.45 Pain Relevance 1.12

These drugs also inhibited NF-kappaB activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P.

Positive_regulation (activation) of NF-kappaB in dorsal root ganglia associated with substance p

6) Confidence 0.70 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 18615578 Disease Relevance 0.43 Pain Relevance 1.13

Our results support NF-kappaB activation in EAN during the induction stage as well as in the disease remission.

Positive_regulation (activation) of NF-kappaB associated with disease and neuritis

7) Confidence 0.69 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16516982 Disease Relevance 0.68 Pain Relevance 0.51

These findings indicate that excess mechanical stress increases NF-kappaB activation in the TMJ and suggest that active NF-kappaB is involved in the progression of TMJ inflammation.

Positive_regulation (activation) of NF-kappaB in TMJ associated with stress, snapping jaw and inflammation

8) Confidence 0.69 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12598546 Disease Relevance 0.89 Pain Relevance 0.45

NF-kappaB activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis.

Positive_regulation (activation) of NF-kappaB in temporomandibular joints associated with synovitis

9) Confidence 0.69 Published 2003 Journal J. Dent. Res. Section Title Doc Link 12598546 Disease Relevance 0.69 Pain Relevance 0.41

These results suggest that atorvastatin may be a novel and promising candidate for future treatment or prophylaxis of migraine via attenuating activation of NF-kappaB in trigeminal nucleus caudalis.

Positive_regulation (activation) of NF-kappaB in nucleus associated with migraine

10) Confidence 0.69 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.39 Pain Relevance 0.32

Thus, this study aims to explore whether atorvastatin attenuates NF-kappaB activation in trigeminal nucleus caudalis in a nitroglycerin-induced migraine model.

Spec (whether) Positive_regulation (activation) of NF-kappaB in nucleus associated with migraine

11) Confidence 0.69 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.35 Pain Relevance 0.32

CONCLUSION: The activation of NF-kappaB and its downstream inflammatory mediators may be involved in the regulation of neuropathic pain.

Positive_regulation (activation) of NF-kappaB

12) Confidence 0.69 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646530 Disease Relevance 0 Pain Relevance 0

The DNA binding activity of NF kappa B was increased compared with the hypoxic group.

Positive_regulation (increased) of NF kappa B associated with hypoxia

13) Confidence 0.69 Published 2000 Journal Int J Tissue React Section Abstract Doc Link 11199341 Disease Relevance 0.56 Pain Relevance 0.07

CONCLUSION: The activation of NF-kappaB pathway may contribute to neuropathic pain in CCI rats.

Positive_regulation (activation) of NF-kappaB

14) Confidence 0.69 Published 2006 Journal Br J Anaesth Section Body Doc Link 16885169 Disease Relevance 0.20 Pain Relevance 0

Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.

Positive_regulation (induced) of NF-kB in nucleus associated with spinal cord

15) Confidence 0.68 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.38 Pain Relevance 0.50

Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.

Positive_regulation (activation) of NF-kappaB associated with cox2

16) Confidence 0.68 Published 2001 Journal FASEB J. Section Title Doc Link 11099482 Disease Relevance 0.31 Pain Relevance 0.67

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

Positive_regulation (activation) of NF-kappaB associated with aspirin

17) Confidence 0.67 Published 1996 Journal Science Section Title Doc Link 8910280 Disease Relevance 0.18 Pain Relevance 0.53

In rats pretreated with EcN, a significant downregulation of mRNA and protein expression for IL-1beta, COX-2 and PPARgamma and increased expression of HSP70 without major change in activation of NFkappaB were observed.

Positive_regulation (activation) of NFkappaB

18) Confidence 0.67 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.68 Pain Relevance 0.19

Activation of NF-kappaB in brain areas was detected by means of both the immunohistochemical technique and the Western blot analysis.

Positive_regulation (Activation) of NF-kappaB in brain

19) Confidence 0.67 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.33 Pain Relevance 0.37

In the present study, we sought to elucidate whether NF-kappaB activation might have a role in the determinism of migraine attacks also at the neuronal level.

Positive_regulation (activation) of NF-kappaB in neuronal associated with migraine

20) Confidence 0.67 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.36 Pain Relevance 0.36

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