INT65056

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 3.72
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
cartilage 1
neuron 1
spinal cord 1
motor neurons 1
hippocampus 1
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 54 99.80 Very High Very High Very High
Spinal cord 160 99.50 Very High Very High Very High
gABA 10 99.40 Very High Very High Very High
Hippocampus 43 99.38 Very High Very High Very High
antidepressant 25 98.52 Very High Very High Very High
Fibrositis 4 98.40 Very High Very High Very High
GABAergic 24 96.56 Very High Very High Very High
MU agonist 2 95.60 Very High Very High Very High
Snapping jaw 28 94.80 High High
fluoxetine 37 89.36 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 100.00 Very High Very High Very High
Pain 48 99.80 Very High Very High Very High
Injury 335 98.40 Very High Very High Very High
Fibromyalgia 4 98.40 Very High Very High Very High
Apoptosis 5 96.72 Very High Very High Very High
Nociception 4 95.48 Very High Very High Very High
Temporomandibular Joint Syndrome 28 94.80 High High
Spinal Cord Injury 95 90.24 High High
Targeted Disruption 2 78.08 Quite High
Stroke 20 76.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following a pain-related stimulus, it is released in the spinal cord, where it activates its high-affinity receptor TrkB, leading to the phosphorylation of the mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase (ERK).
TrkB Binding (high-affinity) of in spinal cord associated with pain and spinal cord
1) Confidence 0.36 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 15977164 Disease Relevance 0.32 Pain Relevance 0.37
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
TrkB Binding (leading) of associated with antidepressant
2) Confidence 0.33 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.50
Vaynman et al. (27) reported that exercise-induced increases in synapsin I and synaptophysin in the hippocampus were abrogated by blocking of interaction between BDNF and the BDNF receptor TrkB.
TrkB Binding (interaction) of in hippocampus associated with hippocampus
3) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.15 Pain Relevance 0.14
These studies show that synaptic interactions between full length functional trkB receptors and GABA-containing profiles only occur at non peptidergic synaptic glomeruli of types I and II.
trkB Binding (interactions) of associated with gaba
4) Confidence 0.28 Published 2007 Journal Dev Neurobiol Section Abstract Doc Link 17506495 Disease Relevance 0 Pain Relevance 0.48
Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons.
TrkB Binding (ligands) of in interneurons
5) Confidence 0.15 Published 2008 Journal Neuroscience Section Title Doc Link 18775767 Disease Relevance 0.08 Pain Relevance 0.22
These transcription factors bind to GC-rich elements in the promoter region of target
factors Binding (bind) of
6) Confidence 0.12 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.09 Pain Relevance 0.35
We next assessed the extent to which striatal neuron gene expression responses to BDNF might be conveyed by its high-affinity receptor TrkB.
TrkB Spec (might) Binding (affinity) of in neuron
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.07 Pain Relevance 0.08
The objective of this paper was to describe the number of pain sites (NPS) reported in a population study and its association with demographic, lifestyle, and health-related factors.
factors Binding (association) of associated with pain
8) Confidence 0.04 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18160318 Disease Relevance 0.79 Pain Relevance 0.63
Number of pain sites is associated with demographic, lifestyle, and health-related factors in the general population.
factors Binding (associated) of associated with pain
9) Confidence 0.03 Published 2008 Journal Eur J Pain Section Title Doc Link 18160318 Disease Relevance 0.77 Pain Relevance 0.82
The most striking finding, however, was the weak association with most of the work factors.
factors Binding (association) of
10) Confidence 0.03 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0 Pain Relevance 0
A healthy worker selection, due to the fact that vulnerable or unhealthy persons may have avoided specific high-exposure jobs or changed to lower-exposure jobs before entering the study, may have resulted in underestimation of associations between work factors and psychological distress.
factors Binding (associations) of
11) Confidence 0.02 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0 Pain Relevance 0
Mastery of work and organisational commitment were not significantly related to the level of psychological distress at follow-up, after adjustments for baseline level of psychological distress and background factors (age, gender, marital status, number of preschool children, pregnancy, engagement in special tasks of care taking in the leisure time, regular physical exercise, long-term health problems, and years of experience as nurses' aide) (data not shown).
factors Binding (engagement) of
12) Confidence 0.02 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1693921 Disease Relevance 0 Pain Relevance 0
Activator protein 1 (AP-1) and nuclear factor kappa B (NF-kappa B) represent mammalian transcription factors which bind to distinct enhancer motifs.
factors Binding (bind) of
13) Confidence 0.02 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.33
Classic steroid receptors act as transcription factors, providing an orchestrated gene expression during behavioral demands by direct binding to the DNA and by interaction with other steroid transcription factors (McEwen et al., 1977; Diamond et al., 1990; Cato et al., 1992; Herman, 1993).
factors Binding (interaction) of
14) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3006668 Disease Relevance 0 Pain Relevance 0.14
Matrix and cell surface proteoglycans (PGs) may play important roles in the control of cellular actions of heparan-binding growth factors such as fibroblast growth factor (FGF) during chondrogenesis and osteogenesis, as the inhibition of PG synthesis resulted in reduced incorporation of chondroitin sulfate into cartilage and bone matrix, that was associated with a 75% reduction in cell growth in condyle (equivalent to a reduced volume), determined by DNA synthesis, and in collagenous matrix synthesis in condyle, evaluated by immunohistochemistry.
factors Binding (binding) of in cartilage
15) Confidence 0.01 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC3019198 Disease Relevance 0.09 Pain Relevance 0.09
In addition, it binds to clotting factors and initiates coagulation (35, 36).
factors Binding (binds) of associated with coagulation disorder
16) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063565 Disease Relevance 0.20 Pain Relevance 0
This analysis showed that although we could only ascribe motifs to 6 of the 34 transcription factors encoded by differentially expressed genes, the complex correlation between the timing of their gene expression and the down- or up-regulation of their putative cluster targets suggests an intricate interaction between the transcription factors in shaping the transcriptional response.


factors Binding (interaction) of
17) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.26 Pain Relevance 0.04
There is presently little overlap between the transcription factors associated with the genes included on the RAT230 2 chip and the two databases containing their binding motifs, only 29 overlap with TRANSFAC and 10 with JASPAR (Figure 2A-B).
factors Binding (associated) of
18) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0 Pain Relevance 0
We note that the presented findings resting on this methodology are based on predictions and that more than one transcription factors may bind to the same target.
factors Binding (bind) of
19) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0 Pain Relevance 0.06
Our analysis clearly suggests that the transcriptional response of the motor neurons to injury is complex, and that the observed increased excitability is the result of many interacting factors.
factors Binding (interacting) of in motor neurons associated with injury
20) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.60 Pain Relevance 0.07

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