INT65057

Context Info Confidence 0.47 First Reported 1996 Last Reported 2010 Negated 3 Speculated 1 Reported most in Abstract Documents 28 Total Number 29 Disease Relevance 16.48 Pain Relevance 11.62

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1) cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)

Anatomy Link Frequency spinal cord 2 CAR 1 monocytes 1 esophagus 1 osteoclasts 1 Nfkb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 131 100.00 cytokine 94 100.00 Neuropathic pain 26 100.00 Pain 20 100.00 ketamine 4 100.00 withdrawal 1 99.54 Spinal cord 17 99.38 cINOD 25 99.06 narcan 2 99.06 addiction 1 98.36

Disease Link Frequency Relevance Heat INFLAMMATION 142 100.00 Neuropathic Pain 41 100.00 Apoptosis 40 100.00 Adhesions 2 100.00 Necrosis 8 99.12 Esophageal Cancer 2 99.10 Death 5 98.96 Cancer 30 98.94 Nociception 10 98.32 Nervous System Injury 13 98.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mechanisms of action include competition with pathogens for essential nutrients, induction of epithelial heat-shock proteins, restoring of tight junction protein structure, up-regulation of mucin genes, secretion of defensins, and regulation of the NFkappaB signalling pathway.

Regulation (regulation) of NFkappaB associated with shock

1) Confidence 0.47 Published 2008 Journal Curr. Mol. Med. Section Abstract Doc Link 18537636 Disease Relevance 0.77 Pain Relevance 0.14

Effect of betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines.

Regulation (Effect) of NF-kappaB associated with neuropathic pain and cytokine

2) Confidence 0.41 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16253423 Disease Relevance 0.98 Pain Relevance 1.26

COX-2, iNOS) by an effect on the NF-kappaB transduction system and/or nitrosylation (and thence inhibition) of caspase enzyme activity has been reported.

Regulation (effect) of NF-kappaB

3) Confidence 0.38 Published 2003 Journal Dig Liver Dis Section Abstract Doc Link 12846444 Disease Relevance 0.55 Pain Relevance 0.73

Synthesis of these mediators is regulated by the transcription factor NF-kappaB, which is controlled by the ubiquitin proteasome system (UPS).

Regulation (controlled) of NF-kappaB

4) Confidence 0.37 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506183 Disease Relevance 0.68 Pain Relevance 0.51

Our study was designed to investigate the protective effect of ketamine on the endotoxin-induced proinflammatory cytokines and nuclear factor kappa B (NF-kappaB) activation in vivo.

Spec (investigate) Regulation (effect) of NF-kappaB associated with ketamine and cytokine

5) Confidence 0.36 Published 2004 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 14982564 Disease Relevance 0.29 Pain Relevance 0.35

However, acute naloxone-precipitated withdrawal did not significantly change AP-1 or NF-kappa B activity.

Neg (not) Regulation (change) of NF-kappa B associated with narcan and withdrawal

6) Confidence 0.36 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.40

Therefore, the aim of this investigation was to study the effects of ethanol intake on CAR-IP and NFkappaB activation in pleural fluid neutrophils in P rats.

Regulation (effects) of NFkappaB in CAR

7) Confidence 0.24 Published 2004 Journal Mediators Inflamm Section Abstract Doc Link PMC1781568 Disease Relevance 0.82 Pain Relevance 0.59

This short review summarizes the molecular mechanisms underlying chemopreventive effects of the aforementioned spice ingredients in terms of their effects on intracellular signaling cascades, particularly those involving NF-kappaB and mitogen-activated protein kinases.

Regulation (effects) of NF-kappaB

8) Confidence 0.21 Published 2002 Journal Food Chem. Toxicol. Section Abstract Doc Link 12067569 Disease Relevance 0.32 Pain Relevance 0.20

The aim of this study was to determine which nNOS variants are expressed in the spinal cord in neuropathic rats and deduce their role in neuropathic pain by testing the effects of these kinds of nNOS on nuclear factor-kappaB (NF-kappaB) activity in PC12 cells.

Regulation (effects) of NF-kappaB in spinal cord associated with neuropathic pain and spinal cord

9) Confidence 0.21 Published 2009 Journal J Pain Section Abstract Doc Link 18976964 Disease Relevance 0.62 Pain Relevance 0.51

PC12 cells transfected with the nNOSalpha gene had no effect on NF-kappaB activity, but nNOSbeta without the PDZ domain significantly decreased that in PC12 cells.

Neg (no) Regulation (effect) of NF-kappaB

10) Confidence 0.21 Published 2009 Journal J Pain Section Abstract Doc Link 18976964 Disease Relevance 0.69 Pain Relevance 0.60

Variants of neural nitric oxide synthase in the spinal cord of neuropathic rats and their effects on nuclear factor-kappaB (NF-kappaB) activity in PC12 cells.

Regulation (effects) of NF-kappaB in spinal cord associated with neuralgia, neuropathic pain and spinal cord

11) Confidence 0.21 Published 2009 Journal J Pain Section Title Doc Link 18976964 Disease Relevance 0.58 Pain Relevance 0.66

Effects on NF-kappaB were obtained in treated and untreated osteoclasts.

Regulation (Effects) of NF-kappaB in osteoclasts

12) Confidence 0.14 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15936724 Disease Relevance 0.35 Pain Relevance 0.06

Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression.

Regulation (involved) of NF-kappaB

13) Confidence 0.13 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.43 Pain Relevance 0.40

In the same experiments, extracellular nucleotides also increased DNA binding of nuclear factor kappa B (NF-kB), another transcriptional factor crucially involved in several inflammatory events including reactive astrogliosis.

Regulation (involved) of NF-kB associated with inflammation

14) Confidence 0.11 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.16 Pain Relevance 0.07

Finally, we demonstrate that NSAID-mediated nucleolar translocation of RelA is associated with downregulation of NF-kappaB-driven transcription and of the NF-kappaB target gene, ICAM-1.

Regulation (downregulation) of NF-kappaB associated with cinod

15) Confidence 0.10 Published 2008 Journal Oncogene Section Abstract Doc Link 18059344 Disease Relevance 0.47 Pain Relevance 0.54

Therefore, a modulation of specific participants in the NF-kappaB signal transduction might exert a useful approach for the development of new painkillers.

Regulation (modulation) of NF-kappaB

16) Confidence 0.09 Published 2008 Journal FASEB J. Section Abstract Doc Link 18559989 Disease Relevance 0.98 Pain Relevance 0.47

Apart from the popular monoclonal antibodies and small molecules tyrosine kinase inhibitors, other novel compounds being tested in preclinical and clinical studies target mTOR, NF-kappaB, proteasome and histone deacetylase.

Regulation (target) of NF-kappaB

17) Confidence 0.07 Published 2008 Journal Cancer Metastasis Rev. Section Abstract Doc Link 18427734 Disease Relevance 0.46 Pain Relevance 0.08

In this regard, NF-kappaB is also responsive to reactive oxygen intermediates and calcium.

Regulation (responsive) of NF-kappaB

18) Confidence 0.07 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790762 Disease Relevance 0.09 Pain Relevance 0.47

The single exception was the chain-breaking antioxidant butylated hydroxyanisole (BHA), which markedly inhibited IL-6 and IL-8 secretion, but had no effect on NF-kappaB activation.

Neg (no) Regulation (effect) of NF-kappaB

19) Confidence 0.06 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11768272 Disease Relevance 0.44 Pain Relevance 0.22

Our previous study showed that aspirin induced apoptosis of esophageal cancer cells in vitro by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2.

Regulation (regulation) of NF-kappaB associated with aspirin, esophageal cancer and apoptosis

20) Confidence 0.06 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18058818 Disease Relevance 0.42 Pain Relevance 0.19

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