INT65058

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 36
Total Number 39
Disease Relevance 19.87
Pain Relevance 10.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
ankle joints 2
aorta 1
retina 1
colon 1
muscle 1
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 4 100.00 Very High Very High Very High
Neuritis 11 99.60 Very High Very High Very High
Inflammation 171 99.28 Very High Very High Very High
cytokine 49 99.12 Very High Very High Very High
Paracetamol 71 98.76 Very High Very High Very High
Sciatica 4 98.68 Very High Very High Very High
Freund adjuvant 8 98.52 Very High Very High Very High
COX2 6 98.44 Very High Very High Very High
cOX1 4 98.44 Very High Very High Very High
Spinal cord 18 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 71 100.00 Very High Very High Very High
Low Back Pain 4 100.00 Very High Very High Very High
Rectal Cancer 69 99.86 Very High Very High Very High
Necrosis 27 99.70 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.60 Very High Very High Very High
Diabetes Mellitus 24 99.58 Very High Very High Very High
Pancreatitis 15 99.56 Very High Very High Very High
Cancer 267 99.52 Very High Very High Very High
INFLAMMATION 187 99.28 Very High Very High Very High
Granuloma 4 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevated DNA-binding activity of the NF-kappaB/p50 homodimer and p50, as well as the neuronal expression of SP and CGRP, observed in the ankle joints of arthritic rats were normalized after treatment with MG132.
NF-kappaB Binding (binding) of in ankle joints
1) Confidence 0.45 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506183 Disease Relevance 0.07 Pain Relevance 0
RESULTS: HeLa cells pretreated with indomethacin showed a decrease in the temperature-time combination necessary to inhibit IR-induction of NF-kappaB DNA binding.
NF-kappaB Binding (binding) of in HeLa
2) Confidence 0.45 Published 2002 Journal Int. J. Radiat. Biol. Section Body Doc Link 12065054 Disease Relevance 0 Pain Relevance 0
In cell culture experiments, S1627 inhibited interleukin (IL)-1beta-stimulated nuclear translocation and DNA-binding of NF-kappaB.
NF-kappaB Binding (binding) of
3) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 1.26 Pain Relevance 0.63
Oral aspirin (as a representative of the salicylate family) inhibited diabetes-induced increase in NF-kappaB DNA-binding affinity in electrophoretic mobility shift assay and transcription factor array in nuclear extract isolated from whole retina.
NF-kappaB Binding (affinity) of in retina associated with aspirin and diabetes mellitus
4) Confidence 0.38 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.36 Pain Relevance 0.27
NF-kappaB DNA-binding activity was revealed by electrophoretic mobility shift assay.
NF-kappaB Binding (binding) of
5) Confidence 0.36 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16516982 Disease Relevance 0.51 Pain Relevance 0.51
NF-kappaB DNA-binding activity was revealed by electrophoretic mobility shift assay.
NF-kappaB Binding (activity) of
6) Confidence 0.36 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16516982 Disease Relevance 0.51 Pain Relevance 0.51
The DNA binding activity of NF kappa B was increased compared with the hypoxic group.
NF kappa B Binding (activity) of associated with hypoxia
7) Confidence 0.35 Published 2000 Journal Int J Tissue React Section Abstract Doc Link 11199341 Disease Relevance 0.56 Pain Relevance 0.07
Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.
NF-kB Binding (activity) of in nucleus associated with spinal cord
8) Confidence 0.35 Published 2001 Journal FASEB J. Section Abstract Doc Link 11099482 Disease Relevance 0.43 Pain Relevance 0.50
NF-kappaB DNA-binding activity was analyzed by electromobility shift assay, and changes in the expression of the p50 NF-kappaB subunit and the proinflammatory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) were detected by immunohistochemistry.
NF-kappaB Binding (binding) of
9) Confidence 0.34 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506183 Disease Relevance 0.09 Pain Relevance 0
The elevated DNA-binding activity of the NF-kappaB/p50 homodimer and p50, as well as the neuronal expression of SP and CGRP, observed in the ankle joints of arthritic rats were normalized after treatment with MG132.
NF-kappaB Binding (activity) of in ankle joints
10) Confidence 0.34 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506183 Disease Relevance 0.07 Pain Relevance 0
Thus, similar concentrations of indomethacin both lowered the threshold thermal exposure to inhibit activation of NF-kappaB DNA-binding and increased the sensitivity of tumour cells to hyperthermic radiosensitization-induced cytotoxicity.
NF-kappaB Binding (binding) of
11) Confidence 0.34 Published 2002 Journal Int. J. Radiat. Biol. Section Body Doc Link 12065054 Disease Relevance 0 Pain Relevance 0
Maximum binding of AP-1, NF-kappa B and Oct was found at 0.5, 1 and 2 h after CFA injection, respectively.
NF-kappa B Binding (binding) of associated with freund adjuvant
12) Confidence 0.33 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.32 Pain Relevance 0.70
NF-kappaB decoy may be useful as a target for clarifying the mechanism of sciatica caused by lumbar disc herniation.
NF-kappaB Binding (target) of associated with sciatica
13) Confidence 0.33 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19308465 Disease Relevance 0.99 Pain Relevance 0.90
Similarly in rectal cancer, the most significantly associated NFKB1 SNP, rs230510, appears to independently contribute to decreased risk with no additional information in terms of either effect size or significance, conferred by a second locus (Tables 2 and 3).
NFKB1 Binding (associated) of associated with rectal cancer
14) Confidence 0.32 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 0.39 Pain Relevance 0
The aim of the present study was to establish whether methylprednisolone pretreatment is beneficial and if it can block the pancreatic DNA binding of the transcription factor nuclear factor-kappaB (NF-kappaB) and proinflammatory cytokine synthesis during cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats.
NF-kappaB Binding (binding) of associated with pancreatitis, cholecystokinin and cytokine
15) Confidence 0.32 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.47 Pain Relevance 0.23
Methylprednisolone pretreatment did not influence pancreatic NF-kappaB DNA binding, but decreased proinflammatory cytokine synthesis in this acute pancreatitis model.
NF-kappaB Binding (binding) of associated with pancreatitis and cytokine
16) Confidence 0.32 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.91 Pain Relevance 0.13
The findings suggest that the anti-inflammatory effect of large doses of methylprednisolone in secretagogue-induced pancreatitis occurs downstream of NF-kappaB DNA binding, and that increased pancreatic HSP72 synthesis may play a role in the protective effect of the drug.
NF-kappaB Binding (binding) of associated with inflammation and pancreatitis
17) Confidence 0.32 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12620516 Disease Relevance 0.86 Pain Relevance 0.13
Also the experimental model of hypertension induced by chronic infusion of ANG II induced B1R expression in rat aorta [52] and spinal cord [53] as previously shown in cultured vascular smooth muscle [54] through a mechanism associated with the oxidative stress and NF-kB.
NF-kB Binding (associated) of in aorta associated with stress, pressure and volume under development, b1 receptor and spinal cord
18) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.96 Pain Relevance 0.45
Activator protein 1 (AP-1) and nuclear factor kappa B (NF-kappa B) represent mammalian transcription factors which bind to distinct enhancer motifs.
NF-kappa B Binding (bind) of
19) Confidence 0.28 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.33
Acute (2 h, 4 h) and long-term (72 h) treatment with DAMGO time-dependently increased the DNA-binding activity of both AP-1 and NF-kappa B and the stimulation could be abolished or inhibited by concurrent incubation with naloxone.
NF-kappa B Binding (activity) of associated with narcan
20) Confidence 0.28 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.39

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