INT6507

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 15.35
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C5) extracellular region (C5) response to stress (C5)
Anatomy Link Frequency
pronator teres 2
flexor carpi radialis 2
triceps 2
cleavage 2
spina 1
C5 (Homo sapiens)
Pain Link Frequency Relevance Heat
spondylitis 4 100.00 Very High Very High Very High
imagery 12 99.80 Very High Very High Very High
Arthritis 243 99.52 Very High Very High Very High
rheumatoid arthritis 213 98.80 Very High Very High Very High
Sciatica 14 97.60 Very High Very High Very High
shoulder pain 3 96.08 Very High Very High Very High
Inflammation 63 95.52 Very High Very High Very High
local anesthetic 2 94.24 High High
headache 9 91.96 High High
Pain 14 88.64 High High
Disease Link Frequency Relevance Heat
Nerve Root Compression 38 100.00 Very High Very High Very High
Low Back Pain 7 100.00 Very High Very High Very High
Hyperplasia 202 99.90 Very High Very High Very High
Meningitis 7 99.90 Very High Very High Very High
Spina Bifida Occulta 4 99.76 Very High Very High Very High
Juvenile Chronic Polyarthritis 216 99.52 Very High Very High Very High
Herpes Simplex Virus 3 99.38 Very High Very High Very High
Rheumatoid Arthritis 214 98.80 Very High Very High Very High
Disease 217 98.68 Very High Very High Very High
Osteoarthritis 106 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An association with C5 deficiency.
C5 Binding (association) of
1) Confidence 0.48 Published 1988 Journal Arch. Intern. Med. Section Title Doc Link 3132125 Disease Relevance 0.83 Pain Relevance 0.18
The local anesthetic carbisocaine (1), the monohydrochloride of [2-(heptyloxy)phenyl]-2-(diethylamino)-1-methylethyl ester of carbamic acid, exerts a biphasic effect on the fluidity of egg yolk phosphatidylcholine model membranes as detected by the stearic acid spin probes with the paramagnetic doxyl group bound to C-5 or C-16.
C-5 Binding (bound) of in egg associated with local anesthetic
2) Confidence 0.47 Published 1992 Journal Pharmazie Section Abstract Doc Link 1329120 Disease Relevance 0 Pain Relevance 0.17
In the UK population the TRAF1/C5 association did appear stronger in the anti-CCP- positive subgroup than in the negative subgroup,14 however, the strength of association of the STAT4 locus was similar in both subgroups.
C5 Binding (association) of
3) Confidence 0.40 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.52 Pain Relevance 0.21
To investigate whether the TRAF1/C5 region is associated with a specific phenotype of RA, we next stratified patients for autoantibody status from whom baseline ACPA and RF measurements were available (n = 1,814) Interestingly, SNP14/rs10818488 mainly predisposes to autoantibody-positive disease when compared to controls (OR 1.25, 95% CI 1.11–1.40, p = 2.27 × 10?
C5 Binding (associated) of associated with rheumatoid arthritis and disease
4) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.68 Pain Relevance 0.18
Cervical roentgenography and magnetic resonance imaging revealed spondylitis of C5 and C6.
C5 Binding (spondylitis) of associated with spondylitis and imagery
5) Confidence 0.32 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16247230 Disease Relevance 1.28 Pain Relevance 0.82
In conclusion, by investigating the overlapping of RA and JIA susceptibility loci, we have identified a novel JIA susceptibility locus (STAT4) and confirmed association with a second, TRAF1/C5.
C5 Binding (association) of associated with rheumatoid arthritis and arthritis
6) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2935325 Disease Relevance 0.93 Pain Relevance 0.40
Two JIA susceptibility loci were identified, one of which was a novel JIA association (STAT4) and the second confirmed previously published associations of the TRAF1/C5 locus with JIA.
C5 Binding (associations) of associated with arthritis
7) Confidence 0.30 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2935325 Disease Relevance 1.98 Pain Relevance 0.76
In our patient, ACSP of C5 in association with spina bifida occulta at the same level resulted in a right vertebral hemi-arch with no osseous attachment to the adjacent vertebral bones.
C5 Binding (association) of in spina associated with spina bifida occulta
8) Confidence 0.27 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC2988693 Disease Relevance 0.43 Pain Relevance 0.03
These molecules elicit their immune modulating capacity by binding the C3b part of the C5 convertase complex.
C5 Binding (binding) of
9) Confidence 0.11 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.40 Pain Relevance 0
Efb and Ecb block the formation of C5 convertases and thereby inhibit C5a and MAC generation.
C5 Binding (formation) of
10) Confidence 0.10 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.39 Pain Relevance 0.06
With C-5, C-7, and C-8 radiculopathies, changes were relatively stereotyped, with involvement of the spinati,deltoid, biceps, and brachioradialis with C-5; the pronator teres, flexor carpi radialis, triceps, and anconeus with C-7; and the first dorsal interosseous, abductor digiti minimi, abductor pollicis brevis, flexor pollicis longus, and extensor indicis proprius with C-8.
C-5 Binding (stereotyped) of in pronator teres associated with nerve root compression
11) Confidence 0.07 Published 1996 Journal Neurology Section Abstract Doc Link 8780083 Disease Relevance 0.69 Pain Relevance 0.18
With C-5, C-7, and C-8 radiculopathies, changes were relatively stereotyped, with involvement of the spinati,deltoid, biceps, and brachioradialis with C-5; the pronator teres, flexor carpi radialis, triceps, and anconeus with C-7; and the first dorsal interosseous, abductor digiti minimi, abductor pollicis brevis, flexor pollicis longus, and extensor indicis proprius with C-8.
C-5 Binding (stereotyped) of in pronator teres associated with nerve root compression
12) Confidence 0.07 Published 1996 Journal Neurology Section Abstract Doc Link 8780083 Disease Relevance 0.68 Pain Relevance 0.17
Surface protein gC of Herpes Simplex Virus binds to C3b and inhibits its association with C5 and properdin [59].
C5 Binding (association) of associated with herpes simplex virus
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.29 Pain Relevance 0
In the soft tick Ornithodoros moubata, lipocalin OmCI binds to component C5 and prevents interaction with C5 convertase or blocks the C5a cleavage site.
C5 Binding (interaction) of in cleavage
14) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.24 Pain Relevance 0
Eculizumab is a humanized monoclonal antibody which binds to the complement protein 5 (C5), thereby inhibiting the formation of the terminal components of the complement cascade.1 It was licensed by the Food and Drug Administration in March 2007 and by the European Medicines Agency in June 2007 for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).
C5 Binding (binds) of associated with paroxysmal nocturnal hemoglobinuria
15) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.39 Pain Relevance 0
OmCI binds to C5 component of the complement cascade and belongs to the lipocalin superfamily [33].
C5 Binding (binds) of
16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.17 Pain Relevance 0
Eculizumab is a monoclonal antibody treatment which specifically binds to the complement protein C5, preventing its cleavage, and so halts the complement cascade and prevents the formation of the terminal complement proteins.
C5 Binding (binds) of in cleavage
17) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2789686 Disease Relevance 0.73 Pain Relevance 0.04
Our initial assumption of achieving approximately the previously reported 46% prevalence of CPH was true for C5 and C6 but the actual prevalence at C3 and C4 was lower.
C5 Binding (true) of associated with hyperplasia
18) Confidence 0.03 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1592100 Disease Relevance 0.88 Pain Relevance 0
The C-coefficients and ORs for the segmental relationships between cervical pillar hyperplasia (CPH) and degenerative joint disease (DJD) across all age groups (40–69 years) indicate that the strongest associations of statistical significance occurred at C4 and C5; however, these correlation coefficients and ORs were all considerably weaker than the initially proposed clinically important 'moderate' associations represented by C ?
C5 Binding (occurred) of in joint associated with osteoarthritis and hyperplasia
19) Confidence 0.02 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1592100 Disease Relevance 1.14 Pain Relevance 0
With C-5, C-7, and C-8 radiculopathies, changes were relatively stereotyped, with involvement of the spinati,deltoid, biceps, and brachioradialis with C-5; the pronator teres, flexor carpi radialis, triceps, and anconeus with C-7; and the first dorsal interosseous, abductor digiti minimi, abductor pollicis brevis, flexor pollicis longus, and extensor indicis proprius with C-8.
C-5 Binding (stereotyped) of in triceps associated with nerve root compression
20) Confidence 0.02 Published 1996 Journal Neurology Section Abstract Doc Link 8780083 Disease Relevance 0.68 Pain Relevance 0.17

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