INT65070

Context Info Confidence 0.55 First Reported 1996 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 13 Disease Relevance 7.72 Pain Relevance 1.84

nucleus (SHOX)

Anatomy Link Frequency brain 1 SHOX (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 18 100.00 narcan 3 99.34 electroacupuncture 9 98.68 Acupuncture 7 98.10 Paresthesia 2 97.44 Pain 21 96.84 Analgesic 1 95.16 Inflammation 2 94.60 Migraine 15 69.20 agonist 20 66.32

Disease Link Frequency Relevance Heat Autoimmune Disease 1 99.60 Growth Problems 500 99.02 Dysesthesia 2 97.44 Pain 16 96.84 INFLAMMATION 2 94.60 Growth Hormone Deficiency 35 94.00 Cognitive Disorder 15 92.56 Hypesthesia 3 89.12 Diabetes Mellitus 2 87.04 Disease 19 85.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An example of this situation is a recent report of a child with ISS who was ultimately diagnosed with a deletion in exon 5 of the Short Homeobox X (SHOX) gene.4 A short history of GH therapy

Gene_expression (exon) of SHOX associated with growth problems

1) Confidence 0.55 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 1.43 Pain Relevance 0

It appears that mutations in the GH receptor and the SHOX gene account for between 1% and 5% of the cases of growth failure that are designated ISS.

Gene_expression (account) of SHOX gene associated with growth problems

2) Confidence 0.55 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.83 Pain Relevance 0

Genetic explanations for ISS have occurred in approximately 5% of the patients evaluated, including genetic mutations of the GH-IGF-1 axis, including STAT5b mutations, SHOX gene mutations, and ALS mutations.

Gene_expression (mutations) of SHOX gene associated with growth problems

3) Confidence 0.55 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.56 Pain Relevance 0.03

An example of this situation is a recent report of a child with ISS who was ultimately diagnosed with a deletion in exon 5 of the Short Homeobox X (SHOX) gene.4 A short history of GH therapy

Gene_expression (exon) of Short Homeobox X associated with growth problems

4) Confidence 0.55 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 1.43 Pain Relevance 0

In an analysis of 68 patients with ISS, one female patient was identified who had a normal karyotype but a deletion of one SHOX allele.69

Gene_expression (allele.69) of SHOX associated with growth problems

5) Confidence 0.55 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.79 Pain Relevance 0

1) The stimulus intervals in QSD are jittered, whereas in the SS response they are uniform.

Gene_expression (response) of SS

6) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0.35 Pain Relevance 0.06

The issue of SS studies of supraSTZ rates is discussed later, in a separate section.

Gene_expression (studies) of SS

7) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

4) If the usual practice in SS analysis were done, namely that only the product at the frequency of stimulationis used, then the data obtained from the 6 runs at the bottom of Fig. 26would show marked variation in amplitude even though the actual brain response is the same in every run!

Gene_expression (analysis) of SS in brain

8) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0 Pain Relevance 0

At the root of all this capability and these techniques is the use of the SS stimulation.

Gene_expression (use) of SS

9) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0.39 Pain Relevance 0.07

5) that these results show details that cannot be found with SS methods; and

Gene_expression (methods) of SS

10) Confidence 0.24 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1483834 Disease Relevance 0.13 Pain Relevance 0

The DASH and CTSI-SS are affected more by functional changes, whereas the CTSI-SS is affected by paresthesia or pain (or both), which can improve soon after surgery.

Gene_expression (affected) of CTSI-SS associated with pain and paresthesia

11) Confidence 0.22 Published 2007 Journal J Orthop Sci Section Body Doc Link PMC2778722 Disease Relevance 1.24 Pain Relevance 0.40

Because SS expression is absent in different immune tissues where SSRs are present, the existence of another ligand was hypothesized.

Neg (absent) Gene_expression (expression) of SS associated with somatostatin

12) Confidence 0.13 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16855140 Disease Relevance 0.56 Pain Relevance 0.51

In five dogs prepared with gastric cannulas, gastric acid secretion was determined by a dye-dilution technique for 60 min after intragastric administration of 200 ml of 4% mixed amino acid meal in six different experiments: study 1, no acupuncture; study 2, sham acupuncture (SAP); study 3, EAP; study 4, EAP plus naloxone; study 5, naloxone alone; and study 6, intravenous infusion of somatostatin (SS) and vasoactive intestinal peptide (VIP) at doses of 0.5 and 1.0 micrograms.kg-1.h-1, respectively.

Gene_expression (infusion) of SS associated with somatostatin, narcan, acupuncture and electroacupuncture

13) Confidence 0.02 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8843779 Disease Relevance 0 Pain Relevance 0.77

General Comments

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