INT65071

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Context Info
Confidence 0.18
First Reported 1996
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.44
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TKT) small molecule metabolic process (TKT) nucleolus (TKT)
peroxisome (TKT) nucleus (TKT) carbohydrate metabolic process (TKT)
Anatomy Link Frequency
brain 2
TKT (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 97.04 Very High Very High Very High
corticosteroid 1 62.44 Quite High
palliative 1 60.56 Quite High
Arthritis 12 50.00 Quite Low
cytokine 25 46.56 Quite Low
imagery 6 39.08 Quite Low
tolerance 14 37.68 Quite Low
visual analogue scale 7 30.48 Quite Low
Inflammation 30 25.20 Quite Low
cINOD 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 2 100.00 Very High Very High Very High
Cancer 268 99.64 Very High Very High Very High
Liver Failure 2 99.36 Very High Very High Very High
Brain Tumor 3 99.20 Very High Very High Very High
Hepatocellular Cancer 4 98.84 Very High Very High Very High
Disease 39 97.52 Very High Very High Very High
Rheumatoid Arthritis 1 97.04 Very High Very High Very High
Herpes Simplex Virus 4 93.88 High High
Cytomegalovirus Infection 4 92.92 High High
Suicidal Behaviour 2 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study will evaluate the use of adenovirus-mediated transfer of the HSV-TK gene into primary human brain tumors followed by systemic treatment with ganciclovir.
Positive_regulation (transfer) of Gene_expression (transfer) of HSV-TK gene in brain associated with cold sores and brain tumor
1) Confidence 0.18 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8844206 Disease Relevance 1.71 Pain Relevance 0.09
occurred following TK expression in nontumour cells, emphasized the need to target the expression of the tk gene to tumor cells using a hepatoma-specific promoter such as AFP
Positive_regulation (following) of Gene_expression (expression) of TK associated with cancer and hepatocellular cancer
2) Confidence 0.08 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.25 Pain Relevance 0
occurred following TK expression in nontumour cells, emphasized the need to target the expression of the tk gene to tumor cells using a hepatoma-specific promoter such as AFP
Positive_regulation (following) of Gene_expression (expression) of tk associated with cancer and hepatocellular cancer
3) Confidence 0.08 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.28 Pain Relevance 0
TK discovered IL-6; developed anti-IL-6 receptor therapies for Castleman's disease and rheumatoid arthritis; collaborated with PW to obtain MRA for a trial in Caucasian children with sJIA.



Positive_regulation (discovered) of Gene_expression (discovered) of TK associated with rheumatoid arthritis and disease
4) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297576 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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