INT65072

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Context Info
Confidence 0.65
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 21
Disease Relevance 17.58
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TKT) small molecule metabolic process (TKT) nucleolus (TKT)
peroxisome (TKT) nucleus (TKT) carbohydrate metabolic process (TKT)
Anatomy Link Frequency
joint 1
SLNs 1
brain 1
gut 1
TKT (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 36 100.00 Very High Very High Very High
imagery 218 99.86 Very High Very High Very High
Pain 104 99.12 Very High Very High Very High
Inflammation 167 98.88 Very High Very High Very High
positron emission tomography 75 98.64 Very High Very High Very High
rheumatoid arthritis 2 97.04 Very High Very High Very High
nud 4 94.12 High High
addiction 3 83.20 Quite High
Morphine 6 80.48 Quite High
opiate 6 79.56 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 2240 100.00 Very High Very High Very High
Cancer 1957 99.84 Very High Very High Very High
Glioblastoma 46 99.72 Very High Very High Very High
Brain Tumor 21 99.20 Very High Very High Very High
Pain 125 99.12 Very High Very High Very High
Liver Failure 6 98.96 Very High Very High Very High
INFLAMMATION 188 98.88 Very High Very High Very High
Hepatocellular Cancer 34 98.84 Very High Very High Very High
Disease 289 97.52 Very High Very High Very High
Skin Cancer 87 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGFR-TKI resistance represents another major issue for research.
Gene_expression (resistance) of TKI
1) Confidence 0.65 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880339 Disease Relevance 0.37 Pain Relevance 0
The likelihood of TK transmission is affected by work patterns, which influences the amount of time an individual spends in the natural environment performing agricultural work.
Gene_expression (transmission) of TK
2) Confidence 0.64 Published 2008 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2275234 Disease Relevance 0 Pain Relevance 0
In summary, the likelihood of a continued decline in TK transmission across generations is great and will be most notable amongst women.
Gene_expression (transmission) of TK
3) Confidence 0.55 Published 2008 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2275234 Disease Relevance 0.06 Pain Relevance 0.04
Pathophysiological implications of TKs in the digestive tract include changes in TK innervation, in the expression of TKs and TK receptors, which result in inflammation- and immune-induced disturbances of gut functions, such as dysmotility (diarrhoea/constipation), secretory diarrhoea and visceral hyperalgesia.
Gene_expression (expression) of TK in gut associated with constipation, diarrhoea, inflammation and nud
4) Confidence 0.42 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16918330 Disease Relevance 1.07 Pain Relevance 0.33
Much of this research assumes that TK can be imposed upon a SK classification of living things.
Gene_expression (imposed) of TK
5) Confidence 0.36 Published 2010 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2828978 Disease Relevance 0 Pain Relevance 0
It has been shown, for the first time, that the NV1023 HSV vector expressing the tk gene can track to draining lymph nodes following direct intratumoral injection and infect metastatic melanoma cells in the SLNs.
Gene_expression (expressing) of tk in SLNs associated with cold sores and skin cancer
6) Confidence 0.21 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.21 Pain Relevance 0.32
This study will evaluate the use of adenovirus-mediated transfer of the HSV-TK gene into primary human brain tumors followed by systemic treatment with ganciclovir.
Gene_expression (transfer) of HSV-TK gene in brain associated with cold sores and brain tumor
7) Confidence 0.20 Published 1996 Journal Hum. Gene Ther. Section Abstract Doc Link 8844206 Disease Relevance 1.71 Pain Relevance 0.09
In vivo, the expression of autologous tk gene in association with GCV was shown to be highly efficient in both reducing small tumour masses growth rates and also in inhibiting tumour cell engraftment.
Gene_expression (expression) of tk associated with cancer
8) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.87 Pain Relevance 0.03
Current research on imaging HSV-1-tk gene expression is focusing on: 1) methods for exact quantification of HSV-1-TK expression, 2) improved HSV-1-TK probes for PET and SPECT, 3) translation of this imaging paradigm into other vector systems, 4) imaging follow-up in cancer therapy strategies, 5) imaging transcriptional activation, and 6) multimodal imaging by fusing the HSV-1-tk gene with further imaging genes.


Gene_expression (expression) of tk associated with cold sores, cancer, positron emission tomography and imagery
9) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.15 Pain Relevance 0.51
Current research on imaging HSV-1-tk gene expression is focusing on: 1) methods for exact quantification of HSV-1-TK expression, 2) improved HSV-1-TK probes for PET and SPECT, 3) translation of this imaging paradigm into other vector systems, 4) imaging follow-up in cancer therapy strategies, 5) imaging transcriptional activation, and 6) multimodal imaging by fusing the HSV-1-tk gene with further imaging genes.


Gene_expression (expression) of TK associated with cold sores, cancer, positron emission tomography and imagery
10) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.13 Pain Relevance 0.53
Time-dependent and spatial relationships of HSV-1-tk and lacZ gene co-expression in culture and in vivo indicate the potential for indirect in vivo imaging of therapeutic gene expression in tumour tissue infected with any recombinant HSV-1 vector where a therapeutic gene is substituted for the lacZ gene.
Gene_expression (expression) of tk associated with cold sores, cancer and imagery
11) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.06 Pain Relevance 0.28
Expression of enkephalin from TK-negative vectors did not only reduce pain-related behaviours, but also prevented cartilagine and bone distruction in the inflamed joint.
Gene_expression (Expression) of TK in joint associated with pain and enkephalin
12) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.16 Pain Relevance 1.22
TK gene expression has been placed under the control of the alpha-fetoprotein promoter to enhance specificity for HCC cells and to diminish tk/gancyclovir toxicity to normal cells.
Gene_expression (expression) of TK associated with toxicity
13) Confidence 0.13 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.89 Pain Relevance 0
occurred following TK expression in nontumour cells, emphasized the need to target the expression of the tk gene to tumor cells using a hepatoma-specific promoter such as AFP
Gene_expression (expression) of tk associated with cancer and hepatocellular cancer
14) Confidence 0.10 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.21 Pain Relevance 0
Tumour cells have high levels of free E2F and therefore genes that have E2F responsive elements (E1A, TS, TK, dhfr, E2F itself etc.) should be more highly expressed in tumour cells.
Gene_expression (expressed) of TK associated with cancer
15) Confidence 0.10 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.14 Pain Relevance 0
occurred following TK expression in nontumour cells, emphasized the need to target the expression of the tk gene to tumor cells using a hepatoma-specific promoter such as AFP
Gene_expression (expression) of TK associated with cancer and hepatocellular cancer
16) Confidence 0.10 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.24 Pain Relevance 0
Enzymes and prodrugs (TK) [95]
Gene_expression (prodrugs) of TK
17) Confidence 0.10 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.71 Pain Relevance 0.04
When coupled with a radioisotope, radiolabeled FIAU (rFIAU) can be detected using SPECT or PET to localize TK-expressing cells in humans.
Gene_expression (expressing) of TK
18) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1994593 Disease Relevance 0.60 Pain Relevance 0.08
The development of EGFR inhibitors has led to the emergence of two classes of compounds: (1) monoclonal antibodies (MoAbs) directed against the extracellular domain of the EGFR (eg, cetuximab, panitumumab [ABX-EGF], and matuzumab [EMD 7200]); and (2) specific small-molecule inhibitors of the intracellular TK domain of EGFR (eg, erlotinib and gefitinib).
Gene_expression (domain) of TK
19) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721355 Disease Relevance 0.80 Pain Relevance 0
TK discovered IL-6; developed anti-IL-6 receptor therapies for Castleman's disease and rheumatoid arthritis; collaborated with PW to obtain MRA for a trial in Caucasian children with sJIA.



Gene_expression (discovered) of TK associated with rheumatoid arthritis and disease
20) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297576 Disease Relevance 0.19 Pain Relevance 0.05

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