INT65078

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 64
Total Number 64
Disease Relevance 15.48
Pain Relevance 59.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
neurons 9
spinal cord 4
plasma 2
tail 2
brain 2
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 552 100.00 Very High Very High Very High
narcan 85 100.00 Very High Very High Very High
Opioid 76 100.00 Very High Very High Very High
antagonist 61 100.00 Very High Very High Very High
opioid receptor 61 100.00 Very High Very High Very High
Spinal cord 33 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
Enkephalin 26 100.00 Very High Very High Very High
Cholecystokinin 18 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 8 99.98 Very High Very High Very High
Migraine Without Aura 4 99.84 Very High Very High Very High
Bradycardia 2 99.80 Very High Very High Very High
Nervous System Injury 13 99.72 Very High Very High Very High
Nociception 31 99.56 Very High Very High Very High
Neuropathic Pain 19 99.12 Very High Very High Very High
Convulsion 20 99.08 Very High Very High Very High
Urological Neuroanatomy 16 98.92 Very High Very High Very High
Injury 2 98.92 Very High Very High Very High
Hyperalgesia 19 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that trauma amplified the activity of peritoneal macrophage, but inhibited Orphanin FQ and its receptor NP4 transcripts in the central nervous system, in the mean time, IL-1beta transcripts in the central nervous system was also augmented.
Negative_regulation (inhibited) of Orphanin FQ in central nervous system associated with orphanin, injury and central nervous system
1) Confidence 0.59 Published 2002 Journal Acupunct Electrother Res Section Abstract Doc Link 12044017 Disease Relevance 0.28 Pain Relevance 0.65
The inhibitory effect of orphanin FQ is dose dependent and probably involves a presynaptic mechanism, as suggested by the significantly increased paired-pulse facilitation evoked in the presence of orphanin FQ.
Negative_regulation (effect) of orphanin FQ associated with orphanin
2) Confidence 0.59 Published 1997 Journal Hippocampus Section Abstract Doc Link 9138672 Disease Relevance 0 Pain Relevance 0.79
Nociceptin levels were further reduced in six patients studied in the first 3 h of typical migraine attacks (1.04 +/- 0.17 pg/ml).
Negative_regulation (reduced) of Nociceptin associated with migraine and orphanin
3) Confidence 0.58 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15773823 Disease Relevance 0.62 Pain Relevance 1.19
Nociceptin inhibition of acetylcholine efflux from different brain areas.
Negative_regulation (inhibition) of Nociceptin in brain associated with orphanin
4) Confidence 0.51 Published 2003 Journal Neuroreport Section Title Doc Link 14625441 Disease Relevance 0 Pain Relevance 0.45
Plasma nociceptin levels are reduced in migraine without aura.
Negative_regulation (reduced) of nociceptin in Plasma associated with migraine and orphanin
5) Confidence 0.51 Published 2005 Journal Cephalalgia Section Title Doc Link 15773823 Disease Relevance 0.60 Pain Relevance 1.15
This inhibitory effect of nociceptin was enhanced in the presence of the alpha2-adrenoceptor antagonist rauwolscine (maximum inhibition by 25% and 50% in the absence and presence of rauwolscine, respectively).
Negative_regulation (effect) of nociceptin associated with antagonist and orphanin
6) Confidence 0.49 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879729 Disease Relevance 0 Pain Relevance 0.88
Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle.
Negative_regulation (decreases) of nociceptin in frontal cortex associated with orphanin, narcan, urological neuroanatomy, withdrawal and opioid
7) Confidence 0.43 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 12093594 Disease Relevance 0.20 Pain Relevance 0.98
The spinal inhibitory effect of nociceptin is not sensitive to antagonists of opioid receptors such as naloxone.
Negative_regulation (effect) of nociceptin in spinal associated with antagonist, orphanin, narcan and opioid receptor
8) Confidence 0.43 Published 2000 Journal Peptides Section Abstract Doc Link 10998537 Disease Relevance 0.36 Pain Relevance 1.15
Nociceptin could inhibit more potently slow-conducting than fast-conducting pain transmission.
Negative_regulation (inhibit) of Nociceptin associated with pain and orphanin
9) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801370 Disease Relevance 0.19 Pain Relevance 0.99
Nociceptin was found to reversibly depress spontaneous dorsal root activity at concentrations of 1.0 microM and 10.0 microM (IC50 2.0 microM), whereas acetyl-nociceptin at concentrations up to 10 microM had no detectable effect.
Negative_regulation (depress) of Nociceptin in dorsal root associated with orphanin
10) Confidence 0.43 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14550927 Disease Relevance 0.09 Pain Relevance 0.68
It is concluded that the predominant action of nociceptin in the spinal cord appears to be inhibitory.
Negative_regulation (inhibitory) of nociceptin in spinal cord associated with orphanin and spinal cord
11) Confidence 0.43 Published 2000 Journal Peptides Section Abstract Doc Link 10998537 Disease Relevance 0.60 Pain Relevance 1.37
Both the impairing and facilitating effect of nociceptin could be blocked by an ORL-1 receptor antagonist, [Phe1Psi(CH(2)-NH)Gly2]NC(1-13)NH2 (10 nmol/rat), indicating that both effects are ORL-1 receptor-mediated.
Negative_regulation (blocked) of nociceptin associated with antagonist and orphanin
12) Confidence 0.43 Published 2004 Journal Brain Res. Section Abstract Doc Link 14706874 Disease Relevance 0.15 Pain Relevance 0.62
Each of the nociceptin actions was dose-dependent in a concentration range of 0.1 to 1 microM, and was largely suppressed by a selective opioid receptor-like1 receptor antagonist, 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (3 microM).
Negative_regulation (suppressed) of nociceptin associated with antagonist, orphanin and opioid receptor
13) Confidence 0.43 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801370 Disease Relevance 0.07 Pain Relevance 1.03
Nociceptin, the endogenous ligand for the ORL1 receptor, has been shown to decrease systemic arterial and hindquarters perfusion pressures in the rat.
Negative_regulation (decrease) of Nociceptin associated with orphanin
14) Confidence 0.43 Published 1997 Journal Peptides Section Abstract Doc Link 9396061 Disease Relevance 0 Pain Relevance 0.36
This effect was specific since the nociceptin antagonist [Phe1psi(CH2-NH)Gly2]NC(1-13)NH2, but not the broad-spectrum opiate antagonist, naloxone, was able to completely block nociceptin actions.
Negative_regulation (block) of nociceptin associated with antagonist, orphanin, narcan and opiate
15) Confidence 0.42 Published 2001 Journal Neuroscience Section Abstract Doc Link 11672600 Disease Relevance 0.16 Pain Relevance 0.82
The effect of nociceptin was blocked significantly by subsequent intra-arcuate nucleus administration of [Nphe(1)]nociceptin(1-13)-NH(2), an ORL1 receptor antagonist.
Negative_regulation (blocked) of nociceptin in arcuate nucleus associated with antagonist and orphanin
16) Confidence 0.42 Published 2004 Journal Brain Res. Section Abstract Doc Link 15464746 Disease Relevance 0.23 Pain Relevance 0.97
Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat.
Negative_regulation (effect) of orphanin FQ associated with antinociception, orphanin, tolerance and morphine
17) Confidence 0.42 Published 1999 Journal Neuroreport Section Title Doc Link 10094142 Disease Relevance 0.16 Pain Relevance 1.43
Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in freshly dissociated hippocampal neurons.
Negative_regulation (inhibition) of orphanin FQ in neurons associated with calcium channel and orphanin
18) Confidence 0.42 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10564368 Disease Relevance 0 Pain Relevance 0.63
Inhibition of nociceptin/orphanin FQ on penicillin-induced seizures in rats.
Negative_regulation (Inhibition) of orphanin FQ associated with convulsion and orphanin
19) Confidence 0.42 Published 2004 Journal Brain Res. Section Title Doc Link 15312806 Disease Relevance 0.80 Pain Relevance 0.68
Naloxone (10 microM), a non-selective opioid receptor antagonist, did not affect the inhibitory effect of nociceptin whereas it abolished that of DAGO.
Negative_regulation (effect) of nociceptin associated with orphanin, antagonist, narcan and opioid receptor
20) Confidence 0.42 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9879729 Disease Relevance 0 Pain Relevance 0.94

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