INT6508

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Context Info
Confidence 0.77
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 11.11
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1) transmembrane transport (RYR1) cytoplasm (RYR1)
Anatomy Link Frequency
skeletal muscle 2
CCO 2
cardiomyocytes 1
muscle 1
central gray 1
RYR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 5 99.92 Very High Very High Very High
Morphine 5 99.30 Very High Very High Very High
narcan 3 99.14 Very High Very High Very High
imagery 134 98.58 Very High Very High Very High
Kinase C 4 98.56 Very High Very High Very High
Calcium channel 15 98.20 Very High Very High Very High
cytokine 10 92.72 High High
anesthesia 124 92.16 High High
bradykinin 8 86.40 High High
Buprenorphine 2 80.72 Quite High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 887 100.00 Very High Very High Very High
Hypoxia 57 99.16 Very High Very High Very High
Channelopathies 5 99.12 Very High Very High Very High
Injury 116 98.92 Very High Very High Very High
Muscle Disease 105 97.92 Very High Very High Very High
Graves' Ophthalmopathy 120 97.32 Very High Very High Very High
Post-traumatic Stress Disorder 108 95.44 Very High Very High Very High
Death 38 93.60 High High
Stress 104 92.92 High High
Arrhythmia Under Development 2 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consistent with the hypothesis that the genetic defect that alters thermoregulation may vary in MHS and that clinical variability in the expression of MHS may be explained by genetic heterogeneity.
Gene_expression (expression) of MHS
1) Confidence 0.77 Published 1991 Journal Genomics Section Abstract Doc Link 1774061 Disease Relevance 0.37 Pain Relevance 0.08
The results of our linkage analyses exclude several loci on 19q13.1 as a site for the gene(s) that produces the MHS phenotype in three unrelated families and clearly establish genetic heterogeneity in this disorder.
Gene_expression (produces) of MHS
2) Confidence 0.77 Published 1991 Journal Genomics Section Abstract Doc Link 1774061 Disease Relevance 0.42 Pain Relevance 0.09
Several observations support the view that a single RYR1 mutation is causal of malignant hyperthermia in all breeds of pigs and in at least some human families: the substitution of Cys for Arg615 as the sole deduced amino acid sequence change in a comparison of malignant hyperthermia and normal porcine RYR1 cDNAs; the linkage of this mutation to malignant hyperthermia in over 450 pigs in six breeds, including 338 meioses; and the appearance of the corresponding mutation, Cys for Arg614, across a species barrier, in a few human families, where it also cosegregates with malignant hyperthermia.
Gene_expression (appearance) of RYR1 associated with malignant hyperthermia
3) Confidence 0.68 Published 1992 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 1329295 Disease Relevance 1.14 Pain Relevance 0
MacLennan, could reside in the skeletal muscle Ca(2+)-release channel gene, RYR1.
Gene_expression (reside) of RYR1 in skeletal muscle
4) Confidence 0.68 Published 1992 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 1329295 Disease Relevance 0.96 Pain Relevance 0
We identified a RYR1 mutation in all 5 patients with MH.
Gene_expression (mutation) of RYR1 associated with malignant hyperthermia
5) Confidence 0.67 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16244001 Disease Relevance 0.48 Pain Relevance 0.09
This channel is termed the ryanodine receptor (RYR).
Gene_expression (termed) of RYR
6) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.68 Pain Relevance 0.10
Interpretation of risk for other family members in the context of RYR1 analysis
Gene_expression (analysis) of RYR1
7) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.24 Pain Relevance 0
As lymphoblastoid cell lines do not express the dihydropyridine receptor, they could also effectively be used to functionally test RYR1 mutations as well as to eliminate RYR1 as a causative factor in MH individuals who do not show linkage to RYR1.
Gene_expression (mutations) of RYR1 associated with malignant hyperthermia
8) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.25 Pain Relevance 0.03
This channel is termed the ryanodine receptor (RYR).
Gene_expression (termed) of ryanodine receptor
9) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.68 Pain Relevance 0.09
Some individuals may wish to delay IVCT or RYR1 analysis, while they consider the information they have been given and/or make the necessary preparations.
Gene_expression (analysis) of RYR1
10) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.21 Pain Relevance 0
Typical muscle imaging findings of patients with proven mutations in the DNM2, SEPN1, ACTA1, RYR1 and collagen 6A1 are provided

Muscle channelopathies and metabolic myopathies

Gene_expression (6A1) of RYR1 in muscle associated with muscle disease, channelopathies and imagery
11) Confidence 0.64 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2940021 Disease Relevance 0.99 Pain Relevance 0.13
Possibly immigrants also displayed higher MHS use prior to the disaster.
Gene_expression (use) of MHS
12) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.06 Pain Relevance 0
Electronic MHS records
Gene_expression (records) of MHS
13) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0 Pain Relevance 0
Another explanation for the higher MHS utilization among immigrants in our sample could be found in the strategy of the MHS-unit which acted pro-actively with regard to minority groups.
Gene_expression (utilization) of MHS
14) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.12 Pain Relevance 0
The prevalence rates of health problems for both MHS-users and non-MHS-users are listed in table 2 and 3.
Gene_expression (users) of non-MHS
15) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0 Pain Relevance 0
Furthermore, they found various results for different subgroups, such as age group (either unrelated to MHS use or older age predicted MHS use), racial group (either no association or immigrants were less likely to use MHS), unemployment (predicting greater MHS use or no relation) [10].
Neg (no) Gene_expression (use) of MHS
16) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.40 Pain Relevance 0
Group differences on demographic characteristics between MHS users and the non-MHS group were examined using Chi square tests (categorical variables) and t-tests (continuous variables).
Gene_expression (group) of non-MHS
17) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.13 Pain Relevance 0
In a critical review of 34 studies regarding health services use among trauma survivors, including disaster survivors, Elhai et al demonstrated that survivors with a previous trauma history and female trauma survivors (veteran studies excluded) more frequently used MHS than their counterparts.
Gene_expression (used) of MHS associated with injury
18) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0.52 Pain Relevance 0
Predictors for post-disaster MHS use
Gene_expression (use) of MHS
19) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0 Pain Relevance 0
The prevalence rates of health problems for both MHS-users and non-MHS-users are listed in table 2 and 3.
Gene_expression (users) of MHS
20) Confidence 0.59 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1949813 Disease Relevance 0 Pain Relevance 0

General Comments

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