INT65081

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Context Info
Confidence 0.35
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 0.62
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPM3) cytoskeleton (TPM3) molecular_function (TPM3)
cytoplasm (TPM3)
Anatomy Link Frequency
TM3 7
TM4 3
TM1 2
TPM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 99.80 Very High Very High Very High
antagonist 80 99.56 Very High Very High Very High
agonist 240 99.28 Very High Very High Very High
Glutamate 2 97.40 Very High Very High Very High
Potency 32 96.84 Very High Very High Very High
mu opioid receptor 5 84.32 Quite High
melanocortin 1 receptor 3 82.72 Quite High
Morphine 1 81.04 Quite High
monoamine 3 79.28 Quite High
Serotonin 8 78.76 Quite High
Disease Link Frequency Relevance Heat
Tics 1 91.00 High High
Overactive Bladder 292 64.76 Quite High
Obesity 9 53.40 Quite High
Respiratory Tract Infection 2 34.52 Quite Low
Gallbladder Disease 4 29.96 Quite Low
Anxiety Disorder 14 5.00 Very Low Very Low Very Low
Heart Rate Under Development 8 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Drug Dependence 5 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transmembrane domains, TM3, TM4, TM5, and TM6, are essential for ligand binding, whereas TM2 (which contains Asp83) and TM7 (which contains Tyr336) are involved in Gs activation [3].
TM5 Binding (binding) of in TM4
1) Confidence 0.35 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC3016425 Disease Relevance 0.12 Pain Relevance 0.06
Multiple interactions occur between ligand and receptor, including interactions with Leu-48 (TM1), Ser-52 (TM1), Glu-55 (TM1), Asn-91 (TM2), Glu-94 (TM2), Thr-95 (TM2) Ile-98 (TM2), Asp-121 (TM3), Thr-124 (TM3), Phe-257 (TM6), Phe-283 (TM7), Asn-290 (TM7), and Asp-294 (TM7) of the receptor.
TM3 Binding (interactions) of in TM1
2) Confidence 0.28 Published 1997 Journal J. Mol. Graph. Model. Section Abstract Doc Link 9640562 Disease Relevance 0 Pain Relevance 0.15
These studies provided evidence for distinct binding sites coordinating SERT antagonists and revealed a close interaction between TM1 and TM3 differentially targeted by stereoisomers of CIT.
TM3 Binding (interaction) of in TM3 associated with antagonist
3) Confidence 0.28 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16272152 Disease Relevance 0 Pain Relevance 0.27
The transmembrane domains, TM3, TM4, TM5, and TM6, are essential for ligand binding, whereas TM2 (which contains Asp83) and TM7 (which contains Tyr336) are involved in Gs activation [3].
TM3 Binding (binding) of in TM4
4) Confidence 0.14 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC3016425 Disease Relevance 0.12 Pain Relevance 0.06
The transmembrane domains, TM3, TM4, TM5, and TM6, are essential for ligand binding, whereas TM2 (which contains Asp83) and TM7 (which contains Tyr336) are involved in Gs activation [3].
TM5 Binding (binding) of in TM3
5) Confidence 0.12 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC3016425 Disease Relevance 0.12 Pain Relevance 0.06
These studies provided evidence for distinct binding sites coordinating SERT antagonists and revealed a close interaction between TM1 and TM3 differentially targeted by stereoisomers of CIT.
TM3 Binding (interaction) of in TM1 associated with antagonist
6) Confidence 0.09 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16272152 Disease Relevance 0 Pain Relevance 0.27
These data are interpreted in the context of interactions with the conserved R3.50(165) in TM3.
TM3 Binding (interactions) of in TM3
7) Confidence 0.09 Published 2002 Journal Biochemistry Section Abstract Doc Link 12356297 Disease Relevance 0 Pain Relevance 0.51
The model of the PTH2R - TIP39 complex was constructed by placing the ECD model in such a manner that TIP39 could reach into the transmembrane region and interact with the top of TM3 and TM7, a region which has been experimentally verified to discriminate binding of PTHrP to PTH2R [37,38].
TM3 Binding (binding) of in TM3
8) Confidence 0.08 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
Both types of modulators were found to bind in a cavity within the HD, contacting residues of TM3, TM5 TM6 and TM7, therefore at a site clearly distinct from the glutamate binding site located in the VFT.
TM3 Binding (bind) of in TM3 associated with glutamate
9) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.27
With the assumption that the protonated amine nitrogen, a feature common to all delta opioid ligands, interacts with the highly conserved Asp127 in TM3, a pocket was found that satisfied the criteria of complementarity to the requirements for receptor recognition for these four diverse ligands, two delta selective antagonists (the fused ring naltrindole and the peptide Tyr-Tic-Phe-Phe-NH2) and the two agonists lofentanil and BW373U86 deduced from previous studies of the ligands alone.
TM3 Binding (interacts) of in TM3 associated with tics, antagonist, agonist and opioid
10) Confidence 0.06 Published 1996 Journal Protein Eng. Section Abstract Doc Link 8844829 Disease Relevance 0.09 Pain Relevance 0.44
These modeling studies have putatively identified hAGRP ligand DArg111-mMC4RAsn115 (TM3) and the hAGRP DPhe113-mMC4RPhe176 (TM4) interactions as important for agonist activity.
TM3 Binding (interactions) of in TM4 associated with agonist
11) Confidence 0.05 Published 2004 Journal J. Med. Chem. Section Abstract Doc Link 15615519 Disease Relevance 0.05 Pain Relevance 0.44
The transmembrane domains, TM3, TM4, TM5, and TM6, are essential for ligand binding, whereas TM2 (which contains Asp83) and TM7 (which contains Tyr336) are involved in Gs activation [3].
TM3 Binding (binding) of in TM3
12) Confidence 0.05 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC3016425 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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