INT65085

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1f) signal transducer activity (Htr1f)
Anatomy Link Frequency
blood vessels 1
Htr1f (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Periaqueductal grey 55 91.40 High High
GABAergic 27 88.80 High High
Sumatriptan 45 85.28 High High
antagonist 13 73.76 Quite High
Raphe 3 61.28 Quite High
midbrain 9 50.00 Quite Low
agonist 15 43.36 Quite Low
Ventral tegmentum 1 26.08 Quite Low
Opioid 10 5.00 Very Low Very Low Very Low
Migraine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 55 91.40 High High
Vomiting 4 50.00 Quite Low
Headache 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Photophobia 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DISCUSSION: The efficacy of sumatriptan in migraine headache appears to be mediated through its agonist activity at the serotonin1D receptor, resulting in constriction of dural blood vessels.
Spec (appears) Positive_regulation (mediated) of serotonin1D receptor in blood vessels
1) Confidence 0.53 Published 1995 Journal Ann Pharmacother Section Body Doc Link 8845562 Disease Relevance 0 Pain Relevance 0
While the lack of 5-HT1F mediated inhibition is not consistent with the detection of mRNA for 5-HT1F receptors in the present study, very low levels of 5-HT1F mRNA have been reported in guinea pig [25].
Positive_regulation (reported) of 5-HT1F
2) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.28 Pain Relevance 0.59

General Comments

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