INT651

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 93
Total Number 97
Disease Relevance 37.27
Pain Relevance 29.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
monocyte 4
colon 3
macrophages 2
platelets 2
blood 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 314 100.00 Very High Very High Very High
Analgesic 60 100.00 Very High Very High Very High
cOX1 29 100.00 Very High Very High Very High
Paracetamol 96 99.98 Very High Very High Very High
COX2 52 99.92 Very High Very High Very High
Inflammation 382 99.84 Very High Very High Very High
Osteoarthritis 2 99.84 Very High Very High Very High
aspirin 122 99.66 Very High Very High Very High
medulla 3 99.66 Very High Very High Very High
Cannabinoid receptor 2 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 471 100.00 Very High Very High Very High
Colon Cancer 125 100.00 Very High Very High Very High
Migraine Without Aura 16 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 30 99.98 Very High Very High Very High
Osteoarthritis 2 99.84 Very High Very High Very High
Rheumatoid Arthritis 5 99.08 Very High Very High Very High
Necrosis 17 99.06 Very High Very High Very High
Cancer 275 98.98 Very High Very High Very High
Stress 147 98.96 Very High Very High Very High
Stomach Cancer 24 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We thus speculated that activation of PGHS-1 might be a mechanism by which minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxyde) stimulates hair growth in vivo.
Positive_regulation (activation) of PGHS-1 in hair associated with alopecia
1) Confidence 0.69 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9008235 Disease Relevance 0.42 Pain Relevance 0.33
The effects of the compounds towards the cyclooxygenase activity of monocyte PGHS-2 induced in response to lipopolysaccharide (LPS) was evaluated by measuring the levels of PGE2 produced in plasma.
Positive_regulation (induced) of PGHS in monocyte
2) Confidence 0.68 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.25 Pain Relevance 0.33
When freshly drawn, heparinized human whole blood is incubated with 50 microM calcium ionophore A23187, platelets are stimulated to produce thromboxane B2 (TxB2) by activation of prostaglandin G/H synthase-l (PGHS-1).
Positive_regulation (activation) of prostaglandin G/H synthase in blood
3) Confidence 0.67 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8737748 Disease Relevance 0.09 Pain Relevance 0.16
When freshly drawn, heparinized human whole blood is incubated with 50 microM calcium ionophore A23187, platelets are stimulated to produce thromboxane B2 (TxB2) by activation of prostaglandin G/H synthase-l (PGHS-1).
Positive_regulation (activation) of PGHS-1 in blood
4) Confidence 0.65 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8737748 Disease Relevance 0.09 Pain Relevance 0.16
The effects of L-NMMA in this preparation appear to be due to inhibition of nitric oxide formation rather than caused by cyclooxygenase activation.
Positive_regulation (activation) of cyclooxygenase
5) Confidence 0.62 Published 1996 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 8964801 Disease Relevance 0 Pain Relevance 0.08
Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors.
Positive_regulation (inducible) of cyclooxygenase in platelets associated with cinod
6) Confidence 0.54 Published 1995 Journal Inflamm. Res. Section Title Doc Link 7583521 Disease Relevance 0 Pain Relevance 0.39
The rate of the forward isomerization to EI* is primarily responsible for the selectivity of both NSAIDs for PGHS1.
Positive_regulation (responsible) of PGHS1 associated with cinod
7) Confidence 0.50 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.19
Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in pre-neoplastic tissues and several human cancers including colorectal cancer.
Positive_regulation (inducible) of prostaglandin G/H synthase associated with cancer and colon cancer
8) Confidence 0.49 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.48 Pain Relevance 0.09
We discuss CNS cells types, including neurons, glia, and cerebrovascular elements, where cyclooxygenases-1 and -2 are expressed under normal conditions or can be induced by physiological or pathological stimuli.
Positive_regulation (induced) of cyclooxygenase in neurons associated with central nervous system
9) Confidence 0.49 Published 2000 Journal Curr. Pharm. Des. Section Abstract Doc Link 11203433 Disease Relevance 0.60 Pain Relevance 0.56
By independent single-SNP analyses, three SNPs were shown to increase CRC risk: PTGS1 c.639C>A, IL8 c.-352T>A, and MTHFR c.1286A>C.
Positive_regulation (increase) of PTGS1 associated with colon cancer
10) Confidence 0.47 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.86 Pain Relevance 0.03
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity.
Positive_regulation (evaluated) of cyclooxygenase associated with inflammation and analgesic
11) Confidence 0.46 Published 1984 Journal J. Med. Chem. Section Abstract Doc Link 6436487 Disease Relevance 0.17 Pain Relevance 0.10
These residues of human PGHS-1 were each mutated to the corresponding PGHS-2 residues (His513 --> Arg and Ile523 --> Val) and a double mutant (His513 --> Arg,Ile523 --> Val) containing both residues was also constructed.
Positive_regulation (residues) of PGHS-1
12) Confidence 0.46 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9083063 Disease Relevance 0 Pain Relevance 0
Western blotting data showed a similar distribution of PGHS-1 and -2 in subcellular fractions, and product analysis using isozyme-specific inhibitors suggested that both enzymes generate the same products in NIH 3T3 cells.
Positive_regulation (distribution) of PGHS-1
13) Confidence 0.46 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9545330 Disease Relevance 0.06 Pain Relevance 0.09
Two primary genes are responsible for the genetic control of cyclooxygenase, a constitutive gene (COX-1) and its inducible isoform (COX-2) 23, 24, 25.
Positive_regulation (inducible) of COX-1
14) Confidence 0.45 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1893117 Disease Relevance 0.58 Pain Relevance 0.32
Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent.
Positive_regulation (induced) of cyclooxygenase in skin associated with increased venous pressure under development
15) Confidence 0.44 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7815355 Disease Relevance 0.28 Pain Relevance 0.04
Transcellular formation of thromboxane A(2) in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity.
Positive_regulation (depends) of prostaglandin I-synthase in platelets associated with aspirin
16) Confidence 0.41 Published 2000 Journal Thromb. Res. Section Title Doc Link 10946089 Disease Relevance 0.09 Pain Relevance 0.49
The effects of the compounds towards the cyclooxygenase activity of monocyte PGHS-2 induced in response to lipopolysaccharide (LPS) was evaluated by measuring the levels of PGE2 produced in plasma.
Positive_regulation (induced) of cyclooxygenase in monocyte
17) Confidence 0.40 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.25 Pain Relevance 0.33
The induction of cyclooxygenase-1 by a tobacco carcinogen in U937 human macrophages is correlated to the activation of NF-kappaB.
Positive_regulation (induction) of cyclooxygenase in macrophages associated with cox1
18) Confidence 0.38 Published 2000 Journal Carcinogenesis Section Title Doc Link 10964107 Disease Relevance 0.27 Pain Relevance 0.43
Cyclooxygenase/prostaglandin signaling and breast cancer

Many human cancers exhibit elevated prostaglandin (PG) levels due to upregulation of cyclooxygenase-2 (COX-2), a key enzyme in eicosanoid biosynthesis.

Positive_regulation (upregulation) of cyclooxygenase associated with cancer and breast cancer
19) Confidence 0.38 Published 2007 Journal Breast Cancer Res Section Title Doc Link PMC2206709 Disease Relevance 1.35 Pain Relevance 0.28
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 inhibitors, have promise as anticancer agents.
Positive_regulation (selective) of cyclooxygenase associated with inflammation and cinod
20) Confidence 0.38 Published 2002 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 11854387 Disease Relevance 0.84 Pain Relevance 0.58

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