INT6510

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2010
Negated 12
Speculated 0
Reported most in Abstract
Documents 130
Total Number 131
Disease Relevance 119.20
Pain Relevance 9.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (AFP) extracellular space (AFP) extracellular region (AFP)
cytoplasm (AFP)
Anatomy Link Frequency
liver 23
hepatocytes 6
yolk sac 4
chest 3
blood 3
AFP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 116 99.82 Very High Very High Very High
Bile 16 99.66 Very High Very High Very High
Analgesic 2 99.52 Very High Very High Very High
Pain 36 98.64 Very High Very High Very High
Chronic pancreatitis 3 98.36 Very High Very High Very High
antagonist 9 98.16 Very High Very High Very High
pain flank 1 97.76 Very High Very High Very High
positron emission tomography 14 97.48 Very High Very High Very High
Nicotine 2 97.12 Very High Very High Very High
headache 13 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 887 100.00 Very High Very High Very High
Hyperplasia 7 100.00 Very High Very High Very High
Stomach Cancer 1427 99.98 Very High Very High Very High
Cyst 17 99.98 Very High Very High Very High
Metastasis 1066 99.96 Very High Very High Very High
Adenocarcinoma 272 99.96 Very High Very High Very High
Carcinoma 104 99.96 Very High Very High Very High
Malignant Neoplastic Disease 138 99.72 Very High Very High Very High
Thrombosis 36 99.68 Very High Very High Very High
Renal Cancer 9 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A case of alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastases, responding to chemotherapy, is reported.
Gene_expression (producing) of AFP in liver associated with adenocarcinoma and metastasis
1) Confidence 0.78 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16080552 Disease Relevance 0.71 Pain Relevance 0.12
[A case of renal carcinoma with bone metastasis, producing alpha-fetoprotein].
Gene_expression (producing) of alpha-fetoprotein associated with renal cancer and metastasis
2) Confidence 0.78 Published 1984 Journal Hinyokika Kiyo Section Title Doc Link 6209970 Disease Relevance 0.73 Pain Relevance 0.10
Thus, portal thrombus associated with liver cirrhosis might induce an extremely high level of AFP production.
Gene_expression (production) of AFP in liver associated with cirrhosis and thrombosis
3) Confidence 0.78 Published 1996 Journal Surg. Today Section Abstract Doc Link 8897683 Disease Relevance 0.93 Pain Relevance 0.12
A case of alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastases, responding to chemotherapy, is reported.
Gene_expression (producing) of alpha-fetoprotein in liver associated with adenocarcinoma and metastasis
4) Confidence 0.78 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16080552 Disease Relevance 0.71 Pain Relevance 0.12
Serum levels of alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) were elevated.
Gene_expression (levels) of AFP associated with antagonist
5) Confidence 0.78 Published 2002 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 12658413 Disease Relevance 0.86 Pain Relevance 0.14
Serum levels of alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) were elevated.
Gene_expression (levels) of alpha-fetoprotein associated with antagonist
6) Confidence 0.78 Published 2002 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 12658413 Disease Relevance 0.86 Pain Relevance 0.14
Histological examination, including immunohistochemical study, showed an adenocarcinoma of the colon producing alpha-fetoprotein.
Gene_expression (producing) of alpha-fetoprotein in colon associated with adenocarcinoma
7) Confidence 0.78 Published 1996 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8633553 Disease Relevance 0.43 Pain Relevance 0.09
No serum tumor markers such as alpha-fetoprotein or human chorionic gonadotropin were detectable.
Gene_expression (detectable) of alpha-fetoprotein associated with cancer
8) Confidence 0.78 Published 1999 Journal No Shinkei Geka Section Abstract Doc Link 10190163 Disease Relevance 1.56 Pain Relevance 0.19
No serum tumor markers such as alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) were detectable.
Gene_expression (detectable) of alpha-fetoprotein associated with cancer
9) Confidence 0.78 Published 1991 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 1726235 Disease Relevance 1.61 Pain Relevance 0.09
No serum tumor markers such as alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) were detectable.
Gene_expression (detectable) of AFP associated with cancer
10) Confidence 0.78 Published 1991 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 1726235 Disease Relevance 1.60 Pain Relevance 0.09
Alpha-fetoprotein (AFP)-producing gastric cancer is known to frequently cause multiple liver metastases and to have an extremely poor prognosis.


Gene_expression (producing) of AFP in liver associated with metastasis and stomach cancer
11) Confidence 0.77 Published 2007 Journal World J Surg Oncol Section Abstract Doc Link PMC1939849 Disease Relevance 0.80 Pain Relevance 0
Chiba et al., reported the case of AFP-producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastases responding to paclitaxel/CDDP [25].
Gene_expression (producing) of AFP in liver associated with adenocarcinoma and metastasis
12) Confidence 0.77 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 0.99 Pain Relevance 0.03
FLEP chemotherapy was more effective for stage IV AFP-producing gastric cancer than for stage IV non-AFP-producing gastric cancer, and it improved the prognosis of AFP-producing gastric cancer due to downstaging.
Gene_expression (producing) of AFP associated with stomach cancer
13) Confidence 0.77 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 1.26 Pain Relevance 0.03
Alpha-fetoprotein (AFP)-producing gastric cancer is known to frequently cause multiple liver metastases and to have an extremely poor prognosis.


Gene_expression (producing) of Alpha-fetoprotein in liver associated with metastasis and stomach cancer
14) Confidence 0.77 Published 2007 Journal World J Surg Oncol Section Abstract Doc Link PMC1939849 Disease Relevance 0.80 Pain Relevance 0
Tumor production of AFP was confirmed by immunohistochemical staining (Figure 2A and 2B).
Gene_expression (production) of AFP associated with cancer
15) Confidence 0.77 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1939849 Disease Relevance 0.90 Pain Relevance 0
The histological diagnosis was poorly differentiated adenocarcinoma, and tumor production of AFP was confirmed by immunohistochemical staining.
Gene_expression (production) of AFP associated with adenocarcinoma and cancer
16) Confidence 0.77 Published 2007 Journal World J Surg Oncol Section Abstract Doc Link PMC1939849 Disease Relevance 1.10 Pain Relevance 0
Levels of lactic dehydrogenase, human beta-chorionic gonadotropin, alpha-fetoprotein, DUPAN-2 and carbohydrate antigen 19-9 were elevated.
Gene_expression (Levels) of alpha-fetoprotein
17) Confidence 0.75 Published 2008 Journal Int. J. Urol. Section Abstract Doc Link 18304228 Disease Relevance 0.75 Pain Relevance 0.10
Alpha-fetoprotein producing tumors other than hepatoma and germ cell tumors have been widely reported, especially in carcinoma with hepatoid differentiation (hepatoid carcinoma).
Gene_expression (producing) of Alpha-fetoprotein in germ cell associated with cancer, germ cell and embryonal neoplasms, hepatocellular cancer and carcinoma
18) Confidence 0.75 Published 2004 Journal Eur. J. Gynaecol. Oncol. Section Abstract Doc Link 15597858 Disease Relevance 0.80 Pain Relevance 0.11
Alpha-fetoprotein expressing metastastic adenocarcinoma of the esophago-gastric junction responding favorably to capecitabine and oxaliplatin.
Gene_expression (expressing) of Alpha-fetoprotein associated with adenocarcinoma
19) Confidence 0.75 Published 2009 Journal Anticancer Drugs Section Title Doc Link 19343004 Disease Relevance 0.36 Pain Relevance 0.09
Alpha-fetoprotein-producing metastatic adenocarcinoma of the stomach or the esophago-gastric junction usually exhibits either no or only short-term remission while receiving palliative chemotherapy.
Gene_expression (producing) of Alpha-fetoprotein in stomach associated with adenocarcinoma and palliative
20) Confidence 0.75 Published 2009 Journal Anticancer Drugs Section Abstract Doc Link 19343004 Disease Relevance 0.33 Pain Relevance 0.09

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