INT65109

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 8.63
Pain Relevance 12.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
plasma 8
DRG 6
trigeminal ganglia 2
sciatic nerve 2
motoneurons 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 89 100.00 Very High Very High Very High
calcitonin gene related peptide 20 100.00 Very High Very High Very High
Spinal cord 10 100.00 Very High Very High Very High
dorsal root ganglion 6 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Dorsal horn 3 100.00 Very High Very High Very High
narcan 4 99.76 Very High Very High Very High
Sciatic nerve 6 99.68 Very High Very High Very High
antagonist 6 99.40 Very High Very High Very High
Migraine 10 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Nociception 1 100.00 Very High Very High Very High
Cancer 1 99.56 Very High Very High Very High
Fever 4 99.50 Very High Very High Very High
Necrosis 1 99.32 Very High Very High Very High
Headache 10 98.96 Very High Very High Very High
Neurogenic Inflammation 1 98.66 Very High Very High Very High
Arthritis 16 98.52 Very High Very High Very High
INFLAMMATION 6 97.36 Very High Very High Very High
Neuropathic Pain 27 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Negative_regulation (down) of Transcription (expression) of CGRP associated with substance p and calcitonin gene-related peptide
1) Confidence 0.59 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.95 Pain Relevance 1.11
Studies in cultured trigeminal neurons demonstrate that CGRP is released from trigeminal ganglia cells, that CGRP transcription is increased under conditions mimicking neurogenic inflammation, that migraine pharmacotherapies can both reduce CGRP release and inhibit CGRP transcription, and that tumor necrosis factor-alpha (TNF-alpha), an endogenous inflammatory mediator implicated in migraine, can stimulate CGRP transcription.
Negative_regulation (inhibit) of Transcription (transcription) of CGRP in trigeminal ganglia associated with necrosis, inflammation, cancer, migraine, neurogenic inflammation and calcitonin gene-related peptide
2) Confidence 0.54 Published 2006 Journal Headache Section Abstract Doc Link 16927957 Disease Relevance 1.22 Pain Relevance 1.61
These results demonstrate that activation of the endogenous 5-HT1 receptor is coupled to calcium signaling pathways and leads to inhibition of CGRP gene transcription.
Negative_regulation (inhibition) of Transcription (transcription) of CGRP associated with calcitonin gene-related peptide
3) Confidence 0.45 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9391009 Disease Relevance 0.27 Pain Relevance 0.46
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Negative_regulation (regulated) of Transcription (expression) of CGRP associated with substance p and calcitonin gene-related peptide
4) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.95 Pain Relevance 1.11
The expression of CGRP mRNA (both alpha- and beta-CGRP isoforms), the content of CGRP in laminae I and II of the dorsal horn of the spinal cord and the concentration of CGRP in the plasma was decreased in the rats treated with phenol.
Negative_regulation (decreased) of Transcription (expression) of CGRP in plasma associated with dorsal horn and spinal cord
5) Confidence 0.43 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15120475 Disease Relevance 0.37 Pain Relevance 0.55
The expression of CGRP mRNA (both alpha- and beta-CGRP isoforms), the content of CGRP in laminae I and II of the dorsal horn of the spinal cord and the concentration of CGRP in the plasma was decreased in the rats treated with phenol.
Negative_regulation (decreased) of Transcription (concentration) of CGRP in plasma associated with dorsal horn and spinal cord
6) Confidence 0.43 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15120475 Disease Relevance 0.30 Pain Relevance 0.42
On the other hand, expression of calcitonin gene-related peptide (CGRP) and substance P mRNA was down-regulated 12 days following neurotomy.
Negative_regulation (down-regulated) of Transcription (expression) of calcitonin gene-related peptide associated with substance p and calcitonin gene-related peptide
7) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12787826 Disease Relevance 0.95 Pain Relevance 1.11
The contribution of calcitonin gene-related peptide and its receptors to transmission of presumed nociceptive information appears to be reduced in the sciatic nerve constriction model.
Negative_regulation (reduced) of Transcription (contribution) of calcitonin in sciatic nerve associated with nociception, sciatic nerve and calcitonin gene-related peptide
8) Confidence 0.43 Published 1996 Journal Neuroscience Section Abstract Doc Link 9053804 Disease Relevance 0.32 Pain Relevance 1.22
Budesonide had no effect on constitutive CGRP mRNA levels in motoneurons and attenuated the decrease in CGRP mRNA levels in motoneurons of rats subjected to CIA.
Negative_regulation (decrease) of Transcription (levels) of CGRP in motoneurons associated with calcitonin gene related peptide and arthritis
9) Confidence 0.42 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846393 Disease Relevance 0.78 Pain Relevance 1.02
Budesonide reduced the constitutive CGRP mRNA levels in DRG, compared with untreated control rats, and reversed the CIA-induced increase.
Negative_regulation (reduced) of Transcription (levels) of CGRP in DRG associated with calcitonin gene related peptide and arthritis
10) Confidence 0.42 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846393 Disease Relevance 0.78 Pain Relevance 0.98
All above cultured samples were processed for detecting expression of mRNA for SP, CGRP and vanilloid receptor 1 (VR1) of DRG neurons by RT-PCR, and VR1 protein expression by Western blot.
Negative_regulation (detecting) of Transcription (expression) of CGRP in DRG
11) Confidence 0.41 Published 2006 Journal Neuro Endocrinol. Lett. Section Body Doc Link 17187013 Disease Relevance 0.09 Pain Relevance 0
CGRP mRNA expression in DRG cells was reduced to 40-60% of control levels, the additional intraplantar injections of rhNGF (5 x 4 microg) during this time period were able to raise CGRP mRNA expression again.
Negative_regulation (reduced) of Transcription (expression) of CGRP in DRG associated with dorsal root ganglion and calcitonin gene-related peptide
12) Confidence 0.41 Published 1999 Journal Neurosci. Res. Section Abstract Doc Link 10605941 Disease Relevance 0.37 Pain Relevance 1.02
Hyperthermia treatment significantly reduced infarct size and CK release concomitantly with a dramatic increase in plasma concentrations of CGRP and the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA, which was completely abolished by pretreatment with capsazepine (38 mg/kg, s.c.), a competitive vanilloid receptor 1 antagonist.
Negative_regulation (abolished) of Transcription (expression) of alpha-CGRP in plasma associated with antagonist, fever and calcitonin gene-related peptide
13) Confidence 0.36 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906841 Disease Relevance 0.47 Pain Relevance 0.45
Hyperthermia treatment significantly reduced infarct size and CK release concomitantly with a dramatic increase in plasma concentrations of CGRP and the expression of alpha-CGRP mRNA, but not beta-CGRP mRNA, which was completely abolished by pretreatment with capsazepine (38 mg/kg, s.c.), a competitive vanilloid receptor 1 antagonist.
Negative_regulation (reduced) of Transcription (expression) of alpha-CGRP in plasma associated with antagonist, fever and calcitonin gene-related peptide
14) Confidence 0.36 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906841 Disease Relevance 0.49 Pain Relevance 0.45
We then show that CGS treatment leads to a decrease in CGRP mRNA levels in the CA77 cells.
Negative_regulation (decrease) of Transcription (levels) of CGRP associated with calcitonin gene-related peptide
15) Confidence 0.33 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9391009 Disease Relevance 0.32 Pain Relevance 0.56
As shown in Figure 7 the probes in probe set 1369116_a_at map to exons 2 and 3, which would be present in both calcitonin and CGRP transcripts.
Negative_regulation (present) of Transcription (transcripts) of calcitonin associated with calcitonin gene-related peptide
16) Confidence 0.24 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1784106 Disease Relevance 0 Pain Relevance 0.37
As shown in Figure 7 the probes in probe set 1369116_a_at map to exons 2 and 3, which would be present in both calcitonin and CGRP transcripts.
Negative_regulation (present) of Transcription (transcripts) of CGRP associated with calcitonin gene-related peptide
17) Confidence 0.24 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1784106 Disease Relevance 0 Pain Relevance 0.37

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