INT65119

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Context Info
Confidence 0.41
First Reported 1995
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Des) cytoskeleton (Des) intracellular (Des)
cytoplasm (Des)
Des (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 16 100.00 Very High Very High Very High
cytokine 5 99.04 Very High Very High Very High
Hyperalgesia 12 98.36 Very High Very High Very High
antinociception 2 97.08 Very High Very High Very High
withdrawal 1 91.12 High High
Thermal hyperalgesia 1 83.92 Quite High
antagonist 3 81.20 Quite High
b2 receptor 2 75.00 Quite High
intrathecal 1 75.00 Quite High
Antinociceptive 4 59.04 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 13 98.36 Very High Very High Very High
Necrosis 2 81.76 Quite High
Cancer 1 81.40 Quite High
Nociception 2 75.00 Quite High
Pain 1 70.16 Quite High
Pressure And Volume Under Development 1 69.92 Quite High
INFLAMMATION 2 50.00 Quite Low
Soft Tissue Injuries 2 50.00 Quite Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Edema and tissue damage was quantified by gravimetry and decreased desmin staining.
Negative_regulation (decreased) of desmin
1) Confidence 0.41 Published 2007 Journal Am J Sports Med Section Body Doc Link 17197574 Disease Relevance 0.14 Pain Relevance 0
The antinociceptive effects of DES are not abolished by RES pretreatment, while AM only attenuates the pro-nociceptive effects of RES.
Neg (not) Negative_regulation (abolished) of DES
2) Confidence 0.25 Published 2009 Journal Scand. J. Gastroenterol. Section Body Doc Link 19396660 Disease Relevance 0 Pain Relevance 0
Similarly, des-Arg(9)-BK at the lower dose (0.15 microg) decreased, whereas at the higher dose (6.0 microg) it increased the threshold to thermal noxious stimuli; however, these effects were less pronounced than those of BK.
Negative_regulation (decreased) of des-Arg associated with bradykinin
3) Confidence 0.14 Published 2002 Journal Pharmacology Section Abstract Doc Link 12207114 Disease Relevance 0.17 Pain Relevance 0.78
Coadministration of des-Arg9,Leu8-BK prevented the development of the cytokine-induced hyperalgesia for the duration of the experiment (6 h), but HOE-140 only reversed the hyperalgesia for the 1st h.
Negative_regulation (prevented) of des-Arg9 associated with hyperalgesia, bradykinin and cytokine
4) Confidence 0.01 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846417 Disease Relevance 0.98 Pain Relevance 1.36

General Comments

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