INT6512

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Context Info
Confidence 0.77
First Reported 1980
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 103
Total Number 107
Disease Relevance 76.29
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 35
myeloid cells 3
spine 3
skeleton 2
femur 2
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 160 99.98 Very High Very High Very High
spinal inflammation 9 99.30 Very High Very High Very High
tetrodotoxin 3 98.64 Very High Very High Very High
antagonist 15 98.16 Very High Very High Very High
Pain 142 97.52 Very High Very High Very High
depression 15 97.36 Very High Very High Very High
anesthesia 4 94.72 High High
positron emission tomography 1 94.24 High High
Inflammation 135 93.88 High High
backache 45 93.68 High High
Disease Link Frequency Relevance Heat
Hypercalcemia 1086 100.00 Very High Very High Very High
Immunization 32 100.00 Very High Very High Very High
Hypoxia 8 100.00 Very High Very High Very High
Cancer 387 99.96 Very High Very High Very High
Subacute Combined Degeneration 12 99.94 Very High Very High Very High
Calcification 432 99.82 Very High Very High Very High
Osteoporosis 1835 99.76 Very High Very High Very High
Metastasis 255 99.68 Very High Very High Very High
Malignant Neoplastic Disease 117 99.68 Very High Very High Very High
Disease 284 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localisation studies were undertaken to identify the source of PTH production.
Gene_expression (production) of PTH
1) Confidence 0.77 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.76 Pain Relevance 0.04
This approach was indeed very successful in eradicating PTH production by the metastasis, as has also been subsequently reported in two patients with parathyroid carcinoma and lung metastases [20, 21].
Gene_expression (production) of PTH in parathyroid associated with parathyroid cancer and metastasis
2) Confidence 0.77 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.41 Pain Relevance 0
The beneficial effect was unfortunately transient, lasting only 9 months after the procedure, when PTH production was documented to resume from the same site.
Gene_expression (production) of PTH
3) Confidence 0.77 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.37 Pain Relevance 0
Hypocalcemia, phosphate retention and deficiency of calcitriol stimulate PTH synthesis and secretion and parathyroid cell proliferation, i.e. hyperplasia.
Gene_expression (synthesis) of PTH in parathyroid associated with hypocalcemia and hyperplasia
4) Confidence 0.77 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.82 Pain Relevance 0.06
Patho-physiologic observations suggested that the tumor secreted some humoral substances inhibiting 25-hydroxyvitamin D-1 alpha-hydroxylase activity, renal phosphate resorption, and parathyroid hormone production.
Gene_expression (production) of parathyroid hormone in parathyroid associated with cancer
5) Confidence 0.75 Published 1996 Journal Pathol. Int. Section Abstract Doc Link 10846577 Disease Relevance 0.88 Pain Relevance 0.06
Serum levels of parathyroid hormone-related peptide, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha and total serum receptor activator of nuclear factor kappaB ligand were not elevated.
Gene_expression (levels) of parathyroid hormone in parathyroid associated with necrosis and cancer
6) Confidence 0.75 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.79 Pain Relevance 0.17
Local calcium also promotes tumor growth and the production of parathyroid hormone-related peptide which in turn stimulates bone resorption.
Gene_expression (production) of parathyroid hormone in parathyroid associated with cancer and hypercalcemia
7) Confidence 0.75 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15504568 Disease Relevance 1.49 Pain Relevance 0.10
The levels of PTH (0 pg/ml), PTH-related peptide, vitamin D, vitamin A, IGF-1, STH, 5-HIES and interleukin 6 were within normal limits.
Gene_expression (levels) of PTH
8) Confidence 0.75 Published 2001 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 11200666 Disease Relevance 0.09 Pain Relevance 0
Production of parathyroid hormone by oxyphil cells was confirmed by immunohistochemistry.
Gene_expression (Production) of parathyroid hormone in parathyroid
9) Confidence 0.75 Published 2009 Journal Prog. Urol. Section Abstract Doc Link 19800555 Disease Relevance 0.54 Pain Relevance 0.09
The failure of this tumor to produce parathyroid hormone may allow it to escape clinical attention until it has achieved an advanced state.
Gene_expression (produce) of parathyroid hormone in parathyroid associated with cancer
10) Confidence 0.75 Published 1982 Journal Cancer Section Abstract Doc Link 7053835 Disease Relevance 1.21 Pain Relevance 0.08
Hypercalcemia in adult T-cell leukemia has been attributed to increased levels of 1,25-dihydroxyvitamin D (1,25(OH)2D), whereas in other types of leukemia, hypercalcemia has been blamed on direct skeletal invasion by malignant cells, ectopic parathyroid hormone (PTH) production or bone-resorbing cytokines.
Gene_expression (production) of parathyroid hormone in T-cell associated with malignant neoplastic disease, leukemia, hypercalcemia and cytokine
11) Confidence 0.75 Published 1993 Journal Am. J. Med. Sci. Section Abstract Doc Link 8128979 Disease Relevance 0.97 Pain Relevance 0.14
Hypercalcemia in adult T-cell leukemia has been attributed to increased levels of 1,25-dihydroxyvitamin D (1,25(OH)2D), whereas in other types of leukemia, hypercalcemia has been blamed on direct skeletal invasion by malignant cells, ectopic parathyroid hormone (PTH) production or bone-resorbing cytokines.
Gene_expression (production) of PTH in T-cell associated with malignant neoplastic disease, leukemia, hypercalcemia and cytokine
12) Confidence 0.75 Published 1993 Journal Am. J. Med. Sci. Section Abstract Doc Link 8128979 Disease Relevance 0.96 Pain Relevance 0.14
The present data confirm that both doses produced a significant suppression of PTH.
Gene_expression (produced) of PTH
13) Confidence 0.74 Published 2004 Journal Nutr J Section Body Doc Link PMC506781 Disease Relevance 0 Pain Relevance 0
[Primary hyperparathyroidism with serum parathyroid hormone within the normal range].
Gene_expression (hyperparathyroidism) of parathyroid hormone in parathyroid associated with hypercalcemia
14) Confidence 0.68 Published 2000 Journal Ugeskr. Laeg. Section Title Doc Link 11002744 Disease Relevance 0.76 Pain Relevance 0.19
We observed an increase in PTH levels within the total study population; however, PTH levels did not differ between ethnic groups.
Gene_expression (levels) of PTH
15) Confidence 0.68 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC3017021 Disease Relevance 0 Pain Relevance 0
In the total study population, 25(OH)D levels decreased (mean ± SD) from 72.9 ± 30.0 to 63.3 ± 19.8 nmol/L (P < 0.05) and PTH levels increased from 36.2 ± 15.8 to 47.5 ± 21.2 pg/mL (P < 0.05) during BCT.
Gene_expression (levels) of PTH
16) Confidence 0.68 Published 2010 Journal J Int Soc Sports Nutr Section Abstract Doc Link PMC3017021 Disease Relevance 0.15 Pain Relevance 0
We found high levels of parathyroid hormone and low levels of serum calcium caused by secondary hyperparathyroidism.
Gene_expression (levels) of parathyroid hormone in parathyroid associated with hypercalcemia
17) Confidence 0.67 Published 2006 Journal Acta Med Indones Section Abstract Doc Link 16799210 Disease Relevance 1.10 Pain Relevance 0.09
The increasing morbidity attached to repeated surgical interventions has led to the search for other treatment options, such as radiotherapy, chemotherapy, RF ablation, embolisation, use of the calcimimetic cinacalcet and PTH immunisation.
Gene_expression (immunisation) of PTH associated with immunization
18) Confidence 0.67 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.07 Pain Relevance 0
3) and PTH immunisation (n?
Gene_expression (immunisation) of PTH associated with immunization
19) Confidence 0.67 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.98 Pain Relevance 0.06
However, remission was not permanent and PTH levels started to rise within 9 months of RFA.
Gene_expression (levels) of PTH
20) Confidence 0.67 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.95 Pain Relevance 0.04

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