INT65120

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2002
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.07
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
plasma 1
liver 1
spinal cord 1
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 7 100.00 Very High Very High Very High
Morphine 13 99.52 Very High Very High Very High
cytokine 5 99.16 Very High Very High Very High
Buprenorphine 5 99.16 Very High Very High Very High
Dorsal horn 1 98.56 Very High Very High Very High
Hyperalgesia 13 98.48 Very High Very High Very High
Spinal cord 1 97.80 Very High Very High Very High
B1 receptor 4 97.76 Very High Very High Very High
Analgesic 2 96.32 Very High Very High Very High
Opioid 5 92.24 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 14 98.48 Very High Very High Very High
Cancer 3 97.40 Very High Very High Very High
Necrosis 1 88.72 High High
Ganglion Cysts 1 75.44 Quite High
INFLAMMATION 1 68.88 Quite High
Poisoning 1 52.04 Quite High
Myocardial Infarction 1 50.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the contribution of rat UGT1.1 and UGT2B1 in the overall rate of glucuronidation of buprenorphine in the rat liver, hepatic microsomes from Gunn rats (where UGT1.1 activity is absent) and Wistar rats (where UGT1.1 activity is present) were studied.
Spec (investigate) Regulation (contribution) of UGT1 in liver associated with buprenorphine
1) Confidence 0.45 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9029056 Disease Relevance 0.10 Pain Relevance 1.23
Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine.
Spec (whether) Regulation (contribute) of UGT1A1 in plasma associated with cancer, analgesic and morphine
2) Confidence 0.41 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 12185559 Disease Relevance 0.17 Pain Relevance 0.80
B1 immunoreactivity was seen in laminae 1 and 2 of the dorsal horn of the spinal cord, where primary afferents terminate, and on peripheral nerve terminals in the bladder.
Regulation (immunoreactivity) of B1 in spinal cord associated with dorsal horn and spinal cord
3) Confidence 0.21 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11072143 Disease Relevance 0.22 Pain Relevance 0.49
The involvement of bradykinin (BK) B1 and B2 receptors in cytokine-induced hyperalgesia has been studied in the rat.
Regulation (involvement) of B1 associated with hyperalgesia, bradykinin and cytokine
4) Confidence 0.07 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846417 Disease Relevance 0.58 Pain Relevance 0.76

General Comments

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