INT65125

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Context Info
Confidence 0.77
First Reported 1995
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 81
Total Number 84
Disease Relevance 23.90
Pain Relevance 38.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
neurons 15
AMs 6
T cells 5
macrophages 4
interneurons 4
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 943 100.00 Very High Very High Very High
substance P 851 100.00 Very High Very High Very High
antagonist 437 100.00 Very High Very High Very High
agonist 175 100.00 Very High Very High Very High
projection neuron 70 100.00 Very High Very High Very High
qutenza 64 100.00 Very High Very High Very High
Neuropeptide 25 100.00 Very High Very High Very High
c fibre 22 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
rheumatoid arthritis 2 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 2 99.98 Very High Very High Very High
Nociception 127 99.84 Very High Very High Very High
INFLAMMATION 397 99.78 Very High Very High Very High
Pain 189 99.46 Very High Very High Very High
Nervous System Injury 11 99.34 Very High Very High Very High
Sarcoma 1 99.12 Very High Very High Very High
Hyperalgesia 84 98.94 Very High Very High Very High
Ganglion Cysts 8 98.92 Very High Very High Very High
Necrosis 3 98.70 Very High Very High Very High
Neuropathic Pain 124 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the direct effects of CS and SP on the NK1R expression and the involvement of nuclear factor (NF)-kappaB, macrophages were exposed to CS condensate (CSC) and/or SP without or with blocking NK1R or inhibiting NF-kappaB activation in vitro.
Gene_expression (expression) of NK1R in macrophages associated with substance p
1) Confidence 0.77 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.65
Pulmonary SP was increased by CS but almost eliminated by PCF degeneration, which closely correlated to the changes in AMs' NK1R expression.
Gene_expression (expression) of NK1R in AMs associated with substance p
2) Confidence 0.77 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.59
Role of neurogenic substance P in overexpression of alveolar macrophages' neurokinin 1 receptor in mice exposed to cigarette smoke.
Gene_expression (overexpression) of neurokinin 1 receptor in alveolar macrophages associated with substance p
3) Confidence 0.77 Published 2010 Journal Exp. Lung Res. Section Title Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.60
Because CS could stimulate pulmonary C-fibers (PCFs) to release SP, we asked whether this neurogenic SP was responsible for AMs' NK1R overexpression during CS.
Gene_expression (overexpression) of NK1R in AMs associated with c fibre and substance p
4) Confidence 0.77 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.52
Molecular markers, amplified at the single-cell level by RT-PCR, distinguished two neuronal populations in the dorsal horn of the spinal cord: GABAergic/glycinergic inhibitory interneurons, and calbindin (CA) or NK1 receptor (NK1-R) expressing, excitatory interneurons and projection neurons.
Gene_expression (expressing) of NK1-R in interneurons associated with gabaergic, dorsal horn, projection neuron and spinal cord
5) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15157692 Disease Relevance 0 Pain Relevance 0.57
Whereas GABA/glycine interneurons preferentially expressed alpha4alpha6beta2* nAChRs, alpha3beta2alpha7* nAChRs were preferentially expressed by CA or NK1-R expressing neurons.
Gene_expression (expressing) of NK1-R in interneurons associated with gaba
6) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15157692 Disease Relevance 0 Pain Relevance 0.52
Molecular markers, amplified at the single-cell level by RT-PCR, distinguished two neuronal populations in the dorsal horn of the spinal cord: GABAergic/glycinergic inhibitory interneurons, and calbindin (CA) or NK1 receptor (NK1-R) expressing, excitatory interneurons and projection neurons.
Gene_expression (expressing) of NK1 receptor in interneurons associated with gabaergic, dorsal horn, projection neuron and spinal cord
7) Confidence 0.77 Published 2004 Journal Pain Section Abstract Doc Link 15157692 Disease Relevance 0 Pain Relevance 0.57
Treatment of ovariectomized mice with E2, PPT, DPN or P4 did not decrease NK1R gene expression.
Gene_expression (expression) of NK1R
8) Confidence 0.76 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.18 Pain Relevance 0.17
Tacr1 gene expression was also increased in mice treated for 3 h with PPT revealing the participation of ER?.
Gene_expression (expression) of Tacr1
9) Confidence 0.76 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.17 Pain Relevance 0.24
The nociceptive function of SP is mainly attributed to the activation of NK1 receptors (NK1R) that are expressed on nociceptive projection neurons located in lamina I of the dorsal horn [8,11,12].
Gene_expression (expressed) of NK1R in lamina associated with nociception, dorsal horn, projection neuron and substance p
10) Confidence 0.75 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.59 Pain Relevance 1.00
Nociception-evoked alterations in NK-1 receptor gene expression have been studied in rat models of persistent pain but have not been characterized in any murine models of peripheral inflammation.
Gene_expression (expression) of NK-1 receptor gene associated with pain, nociception, inflammation and lasting pain
11) Confidence 0.74 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.63 Pain Relevance 0.52
This study assessed behavioral responses and NK-1 receptor mRNA gene expression in mice receiving formalin or Freund's complete adjuvant (CFA) as an inflammatory stimulus.
Gene_expression (expression) of NK-1 receptor mRNA associated with inflammatory stimuli
12) Confidence 0.74 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.63 Pain Relevance 0.55
Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse.
Gene_expression (expression) of neurokinin-1 receptor associated with inflammation
13) Confidence 0.74 Published 2003 Journal Brain Res. Section Title Doc Link 12535787 Disease Relevance 0.63 Pain Relevance 0.95
These results confirm that mice are hyperalgesic at late time points after formalin or adjuvant injection when NK-1 receptor gene expression is elevated in the dorsal spinal cord.
Gene_expression (expression) of NK-1 receptor gene in spinal cord associated with hyperalgesia and spinal cord
14) Confidence 0.74 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.41 Pain Relevance 0.35
This supports the hypothesis that increased NK-1 receptor gene expression contributes to the development and maintenance of a hyperalgesic state.
Gene_expression (expression) of NK-1 receptor gene associated with hyperalgesia
15) Confidence 0.74 Published 2003 Journal Brain Res. Section Abstract Doc Link 12535787 Disease Relevance 0.44 Pain Relevance 0.31
Lymphocytes also express a functional tachykinin NK1 receptor [47] and are expected to migrate towards substance P [48].
Gene_expression (express) of NK1 receptor in Lymphocytes associated with substance p
16) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.22 Pain Relevance 0.25
Macrophages and DCs are known to express the functional tachykinin NK1 receptor [19,34,35] and are chemotactic towards substance P [36-39].
Gene_expression (express) of NK1 receptor in Macrophages associated with substance p
17) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.29 Pain Relevance 0.40
However, T cells cultured with IL-12 and IL-10 did not express NK-1R.
Neg (not) Gene_expression (express) of NK-1R in T cells
18) Confidence 0.68 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.80 Pain Relevance 0.83
LP T cells from NSAID-treated wild-type controls or from age-matched untreated IL-10(-/-) animals did not express NK-1R or produce IFN-gamma.
Neg (not) Gene_expression (express) of NK-1R in T cells associated with cinod
19) Confidence 0.68 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.72 Pain Relevance 0.73
IL-10 also down-modulated ongoing NK-1R expression.
Gene_expression (expression) of NK-1R
20) Confidence 0.68 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14500676 Disease Relevance 0.81 Pain Relevance 0.83

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