INT6513

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 11.69
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
plasma 4
monocytes 4
osteoblasts 2
limbs 2
parathyroid 2
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 176 100.00 Very High Very High Very High
Infliximab 5 99.72 Very High Very High Very High
5HT 423 99.42 Very High Very High Very High
Dopamine 45 99.40 Very High Very High Very High
spondylitis 6 98.08 Very High Very High Very High
Thalamus 15 96.50 Very High Very High Very High
Anterior cingulate 9 94.94 High High
metalloproteinase 95 94.36 High High
antidepressant 57 92.48 High High
Osteoarthritis 151 91.56 High High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 156 100.00 Very High Very High Very High
Cirrhosis 10 99.84 Very High Very High Very High
Heterotopic Ossification 8 99.84 Very High Very High Very High
Low Back Pain 49 98.08 Very High Very High Very High
Hypercalcemia 23 97.60 Very High Very High Very High
Osteoporosis 75 97.02 Very High Very High Very High
Anxiety Disorder 267 96.80 Very High Very High Very High
Endometriosis (extended) 5 96.76 Very High Very High Very High
Adhesions 34 95.32 Very High Very High Very High
Ankylosis 3 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In biochemical terms, post-menopausal osteoporosis leads to minimum modifications of the phospho-calcium metabolism: only during stages of accelerated bone turnover is it possible to observe a small increase in calciuria, hydroxyprolinuria and serum osteocalcin levels.
Positive_regulation (increase) of Gene_expression (levels) of osteocalcin associated with endometriosis (extended) and osteoporosis
1) Confidence 0.67 Published 1991 Journal Minerva Endocrinol. Section Abstract Doc Link 1770918 Disease Relevance 1.10 Pain Relevance 0.05
Osteocalcin synthesis and TGF-beta1 production were significantly stimulated on the samples exposed to 3 J/cm2.
Positive_regulation (stimulated) of Gene_expression (synthesis) of Osteocalcin
2) Confidence 0.52 Published 2005 Journal Swed Dent J Suppl Section Abstract Doc Link 15906852 Disease Relevance 0.14 Pain Relevance 0
This quantitative study demonstrated a specific and strong overexpression of osteocalcin mRNA in HO-isolated cells associated with a significant upregulation of type 1 collagen and osteonectin mRNA while histological analysis showed only small cellular variations.
Positive_regulation (overexpression) of Gene_expression (overexpression) of osteocalcin mRNA associated with heterotopic ossification
3) Confidence 0.42 Published 2004 Journal Exp. Mol. Pathol. Section Abstract Doc Link 14738867 Disease Relevance 0.90 Pain Relevance 0.08
The pregnant patient had plasma OC concentrations over the 12 hours, exceeding ?
Positive_regulation (over) of Gene_expression (over) of OC in plasma
4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.39 Pain Relevance 0.09
OC concentration in the ultrafiltrate/mean OC concentration of the haemofilter arterial and venous limbs) of 1, consistent with its polar nature and low protein binding (<3%); therefore, the CVVH ultrafiltration rate approximates to the glomerular filtration rate (GFR).[14]
Positive_regulation (mean) of Gene_expression (concentration) of OC in limbs
5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.64 Pain Relevance 0.06
The pregnant patient had plasma OC concentrations over the 12 hours, exceeding ?
Positive_regulation (exceeding) of Gene_expression (over) of OC in plasma
6) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.39 Pain Relevance 0.09
Serum biochemical studies revealed elevated alkaline phosphatase activity and osteocalcin levels, mild to moderately increased 1,25-dihydroxyvitamin D concentrations, and normal parathyroid hormone levels.
Positive_regulation (elevated) of Gene_expression (levels) of osteocalcin in parathyroid
7) Confidence 0.30 Published 1992 Journal Am. J. Med. Section Body Doc Link 1329508 Disease Relevance 0.15 Pain Relevance 0
Four weeks after ectopic implantation in immunodeficient mice, human HSC and MSC co-seeded grafts yielded marked vascular number and diameter, and increased human osteocalcin expression, in comparison to MSC transplantation alone.
Positive_regulation (increased) of Gene_expression (expression) of osteocalcin
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0
Recent biomarker data generated from ASSERT (Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy) [22,40] showed that previously low levels of osteocalcin and bone alkaline phosphatase were significantly increased under infliximab therapy [41].
Positive_regulation (increased) of Gene_expression (levels) of osteocalcin associated with low back pain, spondylitis and infliximab
9) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592781 Disease Relevance 0.91 Pain Relevance 0.61
Indeed, vitamin D3 alone stimulated a 43-fold increase in osteocalcin expression compared to the basal level, whereas the addition of either 1 ?
Positive_regulation (increase) of Gene_expression (expression) of osteocalcin
10) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.11 Pain Relevance 0.03
Human osteocalcin was expressed in the micropores of CP scaffolds and was significantly increased upon co-transplantation of MSCs and CD34+ cells.
Positive_regulation (increased) of Gene_expression (expressed) of osteocalcin
11) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0
Intriguingly, we found OC arise from circulating CD16+ monocytes in PsA, whereas OC were generated from the CD16- subset in healthy controls.
Positive_regulation (circulating) of Gene_expression (arise) of OC in monocytes associated with arthritis
12) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.07 Pain Relevance 0.52
Intriguingly, we found OC arise from circulating CD16+ monocytes in PsA, whereas OC were generated from the CD16- subset in healthy controls.
Positive_regulation (generated) of Gene_expression (arise) of OC in monocytes associated with arthritis
13) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.10 Pain Relevance 0.56
g/ml gal-3 with vitamin D3 induced osteocalcin expression to only 26.5 (p < 0.04) and 6.5 (p < 0.0001) times the basal level, respectively.
Positive_regulation (induced) of Gene_expression (expression) of osteocalcin
14) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.10 Pain Relevance 0.03
g/ml gal-3 almost entirely inhibited osteocalcin production, we further examined the signalling cascades of gal-3 inhibition of vitamin D3-stimulated osteocalcin production with 5 ?
Positive_regulation (stimulated) of Gene_expression (production) of osteocalcin
15) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Furthermore, using human osteoblasts, we showed that gal-3 inhibited osteocalcin production, which is encoded by the most specific and latest gene expressed by differentiated osteoblasts.
Positive_regulation (encoded) of Gene_expression (production) of osteocalcin in osteoblasts
16) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.50 Pain Relevance 0.22
Vitamin D3-stimulated osteocalcin production tended to be inhibited by genistein (35%) and SB202190 (40%), indicating that tyrosine kinases and p38 mitogen-activated protein kinase may be slightly involved (Figure 6).
Positive_regulation (stimulated) of Gene_expression (production) of osteocalcin
17) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
A consensus is emerging regarding an enhanced metabolic activity in several brain areas including the orbitofrontal and anterior cingulate cortices, the ventral striatum (head of the caudate nucleus) and the thalamus (Saxena et al 1998; Baxter 1999; Aouizerate et al 2004), and our knowledge of the physiology of the cortico-subcortical functional loops involving these brain regions in the expression of OC symptoms is increasing.
Positive_regulation (increasing) of Gene_expression (expression) of OC in ventral associated with thalamus and anterior cingulate
18) Confidence 0.11 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.72 Pain Relevance 0.20
After general considerations about the anatomical and functional organization of the 5HT system, the present review examines the putative role of 5HT neurotransmission in OCD through separate and complementary approaches that can be summarized as follows: (1) evaluation of 5HT function in response to drug treatment with a view to establishing strong relationships between the anti-obsessional effects of antidepressant agents acting preferentially by blocking 5HT reuptake process and their influence on peripheral markers of 5HT function; (2) assessment of 5HT function based on direct measurements of some peripheral and central parameters; and (3) exploration of 5HT function with diverse pharmacological challenges for studying a relatively large variety of 5HT receptor subtypes and their importance in the production of OC symptoms.
Positive_regulation (importance) of Gene_expression (production) of OC associated with antidepressant, anxiety disorder and 5ht
19) Confidence 0.10 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.29 Pain Relevance 0.82
Among the putative neuro-transmitter systems that are thought to play a major role in the expression of OC symptoms, the dopamine system with which 5HT interacts, probably represents the most likely candidate.
Positive_regulation (role) of Gene_expression (expression) of OC associated with dopamine and 5ht
20) Confidence 0.10 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.71 Pain Relevance 0.47

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