INT6514

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 30.28
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
parathyroid 28
lung 8
Lips 4
osteoclast 2
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 23 98.88 Very High Very High Very High
antagonist 9 98.40 Very High Very High Very High
depression 3 97.36 Very High Very High Very High
Pain 56 95.60 Very High Very High Very High
Inflammation 70 92.08 High High
withdrawal 17 85.48 High High
pruritus 2 84.24 Quite High
Central nervous system 2 75.20 Quite High
chemokine 2 75.00 Quite High
Osteoarthritis 8 70.64 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 344 100.00 Very High Very High Very High
Cancer 235 100.00 Very High Very High Very High
Metastasis 152 100.00 Very High Very High Very High
Necrosis 26 100.00 Very High Very High Very High
Hypoxia 8 100.00 Very High Very High Very High
Parathyroid Cancer 187 99.52 Very High Very High Very High
Multiple Endocrine Neoplasia Type 1 286 99.08 Very High Very High Very High
Hypocalcemia 5 98.98 Very High Very High Very High
Fatigue 14 98.08 Very High Very High Very High
Hyperplasia 10 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local calcium also promotes tumor growth and the production of parathyroid hormone-related peptide which in turn stimulates bone resorption.
Positive_regulation (promotes) of Gene_expression (production) of parathyroid hormone in parathyroid associated with cancer and hypercalcemia
1) Confidence 0.67 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15504568 Disease Relevance 1.50 Pain Relevance 0.10
Serum levels of parathyroid hormone-related peptide, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha and total serum receptor activator of nuclear factor kappaB ligand were not elevated.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of parathyroid hormone in parathyroid associated with necrosis and cancer
2) Confidence 0.67 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.81 Pain Relevance 0.18
[Primary hyperparathyroidism with serum parathyroid hormone within the normal range].
Positive_regulation (hyperparathyroidism) of Gene_expression (hyperparathyroidism) of parathyroid hormone in parathyroid associated with hypercalcemia
3) Confidence 0.50 Published 2000 Journal Ugeskr. Laeg. Section Title Doc Link 11002744 Disease Relevance 0.76 Pain Relevance 0.19
In the total study population, 25(OH)D levels decreased (mean ± SD) from 72.9 ± 30.0 to 63.3 ± 19.8 nmol/L (P < 0.05) and PTH levels increased from 36.2 ± 15.8 to 47.5 ± 21.2 pg/mL (P < 0.05) during BCT.
Positive_regulation (increased) of Gene_expression (levels) of PTH
4) Confidence 0.50 Published 2010 Journal J Int Soc Sports Nutr Section Abstract Doc Link PMC3017021 Disease Relevance 0.15 Pain Relevance 0
This approach was indeed very successful in eradicating PTH production by the metastasis, as has also been subsequently reported in two patients with parathyroid carcinoma and lung metastases [20, 21].
Positive_regulation (eradicating) of Gene_expression (production) of PTH in parathyroid associated with parathyroid cancer and metastasis
5) Confidence 0.50 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.42 Pain Relevance 0
This study showed that sequential treatment of osteoporotic patients with PTH followed by alendronate results in a further increase in vertebral BMD that is significantly higher than BMD gained with PTH only and also with simultaneous alendronate and PTH.
Positive_regulation (higher) of Gene_expression (gained) of PTH
6) Confidence 0.49 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.06 Pain Relevance 0.07
Hypocalcemia, phosphate retention and deficiency of calcitriol stimulate PTH synthesis and secretion and parathyroid cell proliferation, i.e. hyperplasia.
Positive_regulation (stimulate) of Gene_expression (synthesis) of PTH in parathyroid associated with hypocalcemia and hyperplasia
7) Confidence 0.46 Published 2004 Journal Acta Med Croatica Section Abstract Doc Link 15125393 Disease Relevance 1.82 Pain Relevance 0.06
Continuous high circulating PTH levels versus intermittent peaks of PTH have opposite effects on bone metabolism.
Positive_regulation (circulating) of Gene_expression (levels) of PTH
8) Confidence 0.46 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.27 Pain Relevance 0
Continuous high circulating PTH levels versus intermittent peaks of PTH have opposite effects on bone metabolism.
Positive_regulation (circulating) of Gene_expression (levels) of PTH
9) Confidence 0.46 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.27 Pain Relevance 0
The decrease in intestinal calcium absorption and high prevalence of vitamin D insufficiency and deficiency seen in elderly men both contribute to elevated serum parathyroid hormone (PTH) levels and bone loss (Lips 2001).
Positive_regulation (elevated) of Gene_expression (levels) of PTH in Lips
10) Confidence 0.46 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.76 Pain Relevance 0.03
The increased production of parathyroid hormone causes hypercalcaemia.
Positive_regulation (increased) of Gene_expression (production) of parathyroid hormone in parathyroid associated with hypercalcemia
11) Confidence 0.45 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.71 Pain Relevance 0.14
Fig. 2Radiological (a pre-RF ablation, b after RF ablation) and biochemical changes after RF ablation of the lung metastasis, demonstrating a severe drop in serum PTH concentrations, which persisted for almost a yearFig. 3Radiological and biochemical changes following lobectomy of the lung metastasis, which resulted in only partial improvement in serum calcium and PTH concentrations
Positive_regulation (following) of Gene_expression (concentrations) of PTH in lung associated with metastasis
12) Confidence 0.44 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.94 Pain Relevance 0
Fig. 2Radiological (a pre-RF ablation, b after RF ablation) and biochemical changes after RF ablation of the lung metastasis, demonstrating a severe drop in serum PTH concentrations, which persisted for almost a yearFig. 3Radiological and biochemical changes following lobectomy of the lung metastasis, which resulted in only partial improvement in serum calcium and PTH concentrations
Spec (partial) Positive_regulation (improvement) of Gene_expression (concentrations) of PTH in lung associated with metastasis
13) Confidence 0.44 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.86 Pain Relevance 0
Fig. 2Radiological (a pre-RF ablation, b after RF ablation) and biochemical changes after RF ablation of the lung metastasis, demonstrating a severe drop in serum PTH concentrations, which persisted for almost a yearFig. 3Radiological and biochemical changes following lobectomy of the lung metastasis, which resulted in only partial improvement in serum calcium and PTH concentrations
Positive_regulation (drop) of Gene_expression (concentrations) of serum PTH in lung associated with metastasis
14) Confidence 0.44 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 0.95 Pain Relevance 0
Fig. 2Radiological (a pre-RF ablation, b after RF ablation) and biochemical changes after RF ablation of the lung metastasis, demonstrating a severe drop in serum PTH concentrations, which persisted for almost a yearFig. 3Radiological and biochemical changes following lobectomy of the lung metastasis, which resulted in only partial improvement in serum calcium and PTH concentrations
Positive_regulation (following) of Gene_expression (concentrations) of serum PTH in lung associated with metastasis
15) Confidence 0.44 Published 2010 Journal Horm Cancer Section Body Doc Link PMC3000473 Disease Relevance 1.01 Pain Relevance 0
Bone alkaline phosphatase (bALP) increased in the TOP study, approximately 30% at month 1, 100% at months 6 and 12, and 80% at month 18 in the PTH group,18 and in the POWER study, 98% at month 12 and 115% at month 24 in the PTH + HT group.22 The elevation of bALP decreased slightly in the OLES extension of the TOP study, remaining 27% above the TOP baseline.29
Positive_regulation (increased) of Gene_expression (group,18) of PTH
16) Confidence 0.44 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971708 Disease Relevance 0 Pain Relevance 0
There was a significant increase in serum PTH levels after 24 hours of nifedipine therapy; however, these differences were not evident after 28 days of therapy.
Positive_regulation (increase) of Gene_expression (levels) of serum PTH
17) Confidence 0.43 Published 1995 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 7889637 Disease Relevance 0.25 Pain Relevance 0
This study showed that sequential treatment of osteoporotic patients with PTH followed by alendronate results in a further increase in vertebral BMD that is significantly higher than BMD gained with PTH only and also with simultaneous alendronate and PTH.
Positive_regulation (higher) of Gene_expression (gained) of PTH
18) Confidence 0.43 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.06 Pain Relevance 0.07
The decrease in intestinal calcium absorption and high prevalence of vitamin D insufficiency and deficiency seen in elderly men both contribute to elevated serum parathyroid hormone (PTH) levels and bone loss (Lips 2001).
Positive_regulation (elevated) of Gene_expression (levels) of serum parathyroid hormone in Lips
19) Confidence 0.40 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.76 Pain Relevance 0.03
Interestingly, PTH injections also stimulate the osteoclast-stimulating cytokines (receptor activator of nuclear factor ?
Positive_regulation (stimulate) of Gene_expression (injections) of PTH in osteoclast associated with cytokine
20) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.19 Pain Relevance 0.05

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