INT65149

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.62
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Drb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Migraine 21 99.78 Very High Very High Very High
spinal inflammation 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 3 99.86 Very High Very High Very High
Headache 18 99.78 Very High Very High Very High
Migraine Without Aura 3 99.28 Very High Very High Very High
Disease 3 99.02 Very High Very High Very High
Iridocyclitis 3 98.04 Very High Very High Very High
Low Back Pain 3 75.00 Quite High
Genetic Predisposition To Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls.
Positive_regulation (increased) of DRB1 associated with migraine
1) Confidence 0.53 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16362659 Disease Relevance 0.71 Pain Relevance 0.59
The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls.
Positive_regulation (frequency) of DRB1 associated with migraine
2) Confidence 0.38 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16362659 Disease Relevance 0.66 Pain Relevance 0.55
When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients.
Positive_regulation (increased) of DRB1 associated with epilepsy, migraine and disease
3) Confidence 0.33 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16362659 Disease Relevance 0.74 Pain Relevance 0.63
The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b.
Positive_regulation (increase) of DRB1
4) Confidence 0.26 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07
The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b.
Positive_regulation (increase) of DRB1
5) Confidence 0.26 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07
We found an increase of the B*4001, DRB1*08, and DPB1*0301 alleles, as well as the LMP2 b/b genotype (the latter was most pronounced among patients with acute iridocyclitis), in JAS compared to B27-positive controls.
Positive_regulation (increase) of DRB1 associated with iridocyclitis
6) Confidence 0.17 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07

General Comments

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