INT6515

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 110
Total Number 113
Disease Relevance 45.13
Pain Relevance 10.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblast 10
plasma 3
middle ear 2
blood 2
monocytes 2
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 27 99.44 Very High Very High Very High
Dopamine 131 99.40 Very High Very High Very High
cytokine 230 99.36 Very High Very High Very High
spinal inflammation 145 99.32 Very High Very High Very High
corticosteroid 35 99.22 Very High Very High Very High
5HT 1269 99.16 Very High Very High Very High
Infliximab 6 99.10 Very High Very High Very High
Arthritis 268 99.00 Very High Very High Very High
MU agonist 9 98.44 Very High Very High Very High
Anterior cingulate 27 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 558 100.00 Very High Very High Very High
Ovarian Cancer 82 100.00 Very High Very High Very High
Obesity 153 99.84 Very High Very High Very High
Heterotopic Ossification 30 99.84 Very High Very High Very High
Cancer 399 99.80 Very High Very High Very High
Body Weight 28 99.56 Very High Very High Very High
Influenza Virus Infection 431 99.52 Very High Very High Very High
Drug Dependence 20 99.48 Very High Very High Very High
Influenza In Birds 66 99.40 Very High Very High Very High
Cirrhosis 40 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum type I collagen C-telopeptide (sCTX), urinary free-deoxypyridinoline (ufDPD), bone alkaline phosphatase (ALP) and serum osteocalcin levels were determined.
Gene_expression (levels) of osteocalcin
1) Confidence 0.75 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 15952402 Disease Relevance 0.49 Pain Relevance 0.06
In biochemical terms, post-menopausal osteoporosis leads to minimum modifications of the phospho-calcium metabolism: only during stages of accelerated bone turnover is it possible to observe a small increase in calciuria, hydroxyprolinuria and serum osteocalcin levels.
Gene_expression (levels) of osteocalcin associated with endometriosis (extended) and osteoporosis
2) Confidence 0.75 Published 1991 Journal Minerva Endocrinol. Section Abstract Doc Link 1770918 Disease Relevance 1.03 Pain Relevance 0.05
Heterotopic ossification derived cells were shown to produce osteocalcin, Type 1 collagen, and alkaline phosphatase activity.
Gene_expression (produce) of osteocalcin associated with heterotopic ossification
3) Confidence 0.75 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.58 Pain Relevance 0.07
Levels of osteocalcin, urinarydeoxypyridinoline, OPG and the receptor activator of nuclear factor-kappaB ligand (RANKL) were determined during the hospital stay.
Spec (determined) Gene_expression (Levels) of osteocalcin
4) Confidence 0.75 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17689752 Disease Relevance 0.71 Pain Relevance 0.10
Strong immunostaining of osteopontin appeared in the peripheral area of the stones, whereas osteonectin and osteocalcin were not detected.
Neg (not) Gene_expression (detected) of osteocalcin
5) Confidence 0.75 Published 2001 Journal J Endod Section Abstract Doc Link 11485265 Disease Relevance 0.42 Pain Relevance 0.08
Osteocalcin synthesis in particular was significantly inhibited by high concentration of morphine and enkephalin [10].
Gene_expression (synthesis) of Osteocalcin associated with enkephalin and morphine
6) Confidence 0.73 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1891106 Disease Relevance 0.67 Pain Relevance 0.87
Since reduced osteocalcin production is a marker of decreased osteoblastic activity, this finding could be related to the pathogenesis of osteoporosis secondary to some diseases.
Gene_expression (production) of osteocalcin associated with osteoporosis and disease
7) Confidence 0.69 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.60 Pain Relevance 0.28
Osteocalcin synthesis was significantly inhibited by high concentrations of the mu agonists morphine and (D-Ala(2), N-MePhe(4),Gly(5)-ol)-enkephalin although no changes were seen with the delta agonist (D-Ala(2),D-leu(5))-enkephalin.
Gene_expression (synthesis) of Osteocalcin associated with mu agonist, agonist, enkephalin and morphine
8) Confidence 0.69 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.63 Pain Relevance 1.09
Osteocalcin synthesis and TGF-beta1 production were significantly stimulated on the samples exposed to 3 J/cm2.
Gene_expression (synthesis) of Osteocalcin
9) Confidence 0.58 Published 2005 Journal Swed Dent J Suppl Section Abstract Doc Link 15906852 Disease Relevance 0.14 Pain Relevance 0
Osteoporotic patients were older and had a lower weight and height and elevated serum levels of osteocalcin (3.6+/-2.25 2.63 versus +/-1.55, p=0.05).
Gene_expression (levels) of osteocalcin
10) Confidence 0.58 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17689752 Disease Relevance 0.62 Pain Relevance 0.08
For each patient, pretreatment and posttreatment serum levels of osteocalcin (OC), bone alkaline phosphatase (BALP), aminoterminal (PINP) and carboxyterminal (PICP) propeptides of type I collagen, amino-terminal (NTx) and carboxyterminal (CTx) telopeptides of type I collagen and their combinations were compared with the level and duration of pain response to radionuclide treatment.
Gene_expression (levels) of osteocalcin
11) Confidence 0.58 Published 2010 Journal Eur. J. Nucl. Med. Mol. Imaging Section Body Doc Link 19662405 Disease Relevance 0.16 Pain Relevance 0
In 17 patients with AS, 11 with OA, and 5 controls we performed immunohistochemical analysis of osteoprotegerin (OPG), nuclear factor-kappaB ligand (RANKL), and osteocalcin (OC) expression in osteoblasts and determined the trabecular thickness in AS and OA patients and controls.
Gene_expression (expression) of osteocalcin in osteoblasts
12) Confidence 0.58 Published 2010 Journal J. Rheumatol. Section Body Doc Link 20156950 Disease Relevance 0.17 Pain Relevance 0
A study of bone samples from anti-retroviral therapy-naïve HIV infected subjects compared with healthy controls showed only decreased levels of osteocalcin in individuals with lower CD4 counts.
Gene_expression (levels) of osteocalcin associated with acquired immune deficiency syndrome or hiv infection
13) Confidence 0.58 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 1.42 Pain Relevance 0.04
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (detect) of osteocalcin in osteoblast associated with osteoporosis
14) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.56 Pain Relevance 0
Patients had lower serum levels of osteocalcin and higher levels of serum testosterone, luteinizing hormone (LH), and prolactin than controls with a significant statistical difference.
Gene_expression (levels) of osteocalcin
15) Confidence 0.58 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15592691 Disease Relevance 0.79 Pain Relevance 0.56
We performed Real-time RT-PCR assays to detect the expression levels of osteoblast specific marker genes MSX2 (homeobox gene MSX2), VDR (vitamin D receptor), COL1A1 (collagen 1A1), ALPL (alkaline phosphatase), SPARC (osteonectin), SPP1 (osteopontin) and BGLAP (osteocalcin) to prove the osteoblast phenotype.
Gene_expression (expression) of osteocalcin in osteoblast associated with osteoporosis
16) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.56 Pain Relevance 0
We performed a study on the phosphorus/calcium metabolism and serum levels of osteocalcin (BGP), a protein proposed as constituting the bone turnover index in 31 patients receiving TPN (age 57 +/- 14 years, 22 males and 9 females) diagnosed as suffering from pathology of the digestive tract or geno-urinary pathology.
Gene_expression (levels) of BGP in digestive tract
17) Confidence 0.58 Published 1992 Journal Nutr Hosp Section Abstract Doc Link 1391109 Disease Relevance 0.30 Pain Relevance 0.10
No statistically significant differences in serum osteocalcin levels or adverse events were seen during the study or in AM plasma cortisol levels at month 12.
Gene_expression (levels) of osteocalcin in plasma
18) Confidence 0.58 Published 2001 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 11379808 Disease Relevance 0 Pain Relevance 0
STUDY DESIGN AND METHODS: The possible mechanism of bone pain was investigated by measuring serum levels of osteocalcin (OC), bone-specific alkaline phosphatase (BAP), acid phosphatase (ACP), and tartrate-resistant acid phosphatase (TRAP) in seven healthy progenitor cell donors treated with human recombinant G-CSF administered subcutaneously for 5 consecutive days.
Gene_expression (levels) of osteocalcin
19) Confidence 0.58 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.09 Pain Relevance 0
BGLAP was described as a late marker of developing osteoblasts appearing with matrix mineralization [27] and was maximally expressed on day 21.
Gene_expression (expressed) of BGLAP in osteoblasts
20) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.12 Pain Relevance 0

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