INT65150

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 12.97
Pain Relevance 5.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MSNs 2
brain 1
Drb1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 43 100.00 Very High Very High Very High
spinal inflammation 30 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
Pain 1 99.20 Very High Very High Very High
Arthritis 96 99.00 Very High Very High Very High
Migraine 7 98.56 Very High Very High Very High
Substantia nigra 2 95.60 Very High Very High Very High
Enkephalin 6 95.46 Very High Very High Very High
GABAergic 4 90.44 High High
MU agonist 1 81.60 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 43 100.00 Very High Very High Very High
Low Back Pain 30 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 25 100.00 Very High Very High Very High
Disease 18 99.98 Very High Very High Very High
Systemic Sclerosis 20 99.72 Very High Very High Very High
Arthritis 102 99.00 Very High Very High Very High
Headache 6 98.56 Very High Very High Very High
Rheumatic Diseases 10 90.08 High High
Cognitive Disorder 18 80.96 Quite High
Epilepsy 5 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects.
Spec (examined) Gene_expression (distribution) of DRB1 associated with migraine
1) Confidence 0.44 Published 2005 Journal J Headache Pain Section Abstract Doc Link 16362659 Disease Relevance 0.59 Pain Relevance 0.45
Another apparent difference is that DR4 (DRB1*0401/DRA) expressing mice are susceptible to CIA [19,37] but not to G6PI-induced arthritis.
Gene_expression (expressing) of DRB1 associated with arthritis
2) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.18 Pain Relevance 0.53
CONCLUSIONS: Because HLA-DR*0405 expression fails to protect mice from AIP, the HLA-DRB1*0405 allele appears to be an important risk factor for AIP on the HLA-DRB1*0405/DQB1*0401 haplotype.
Gene_expression (expression) of DRB1
3) Confidence 0.28 Published 2010 Journal Gastroenterology Section Body Doc Link 20303356 Disease Relevance 0.10 Pain Relevance 0
To assess the role of HLA genes other than those encoding B27 in predisposing to JAS and AAS, we analyzed the distribution of B*4001, as well as the DRB1, DPB1, and LMP2 alleles, using PCR-based techniques in 63 JAS and 44 AAS patients (all B27 positive).
Spec (analyzed) Gene_expression (distribution) of DRB1
4) Confidence 0.25 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.14 Pain Relevance 0.07
Much of the genetic contribution to these diseases lies in the MHC, including HLA-DR4 (RA), HLA-B27 (AS), HLA-DRB1*0301, DRB1*1501/*1503, DRB1*08, and C4 null alleles (SLE), and HLA-DRB1*11 and DRB1*1502 (SSc).
Gene_expression (lies) of DRB1 associated with spinal inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus and disease
5) Confidence 0.22 Published 2005 Journal J Rheumatol Suppl Section Abstract Doc Link 15660456 Disease Relevance 1.98 Pain Relevance 0.68
Much of the genetic contribution to these diseases lies in the MHC, including HLA-DR4 (RA), HLA-B27 (AS), HLA-DRB1*0301, DRB1*1501/*1503, DRB1*08, and C4 null alleles (SLE), and HLA-DRB1*11 and DRB1*1502 (SSc).
Gene_expression (lies) of DRB1 associated with spinal inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus and disease
6) Confidence 0.22 Published 2005 Journal J Rheumatol Suppl Section Abstract Doc Link 15660456 Disease Relevance 2.01 Pain Relevance 0.69
Much of the genetic contribution to these diseases lies in the MHC, including HLA-DR4 (RA), HLA-B27 (AS), HLA-DRB1*0301, DRB1*1501/*1503, DRB1*08, and C4 null alleles (SLE), and HLA-DRB1*11 and DRB1*1502 (SSc).
Gene_expression (lies) of DRB1 associated with spinal inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus and disease
7) Confidence 0.22 Published 2005 Journal J Rheumatol Suppl Section Abstract Doc Link 15660456 Disease Relevance 1.97 Pain Relevance 0.67
Much of the genetic contribution to these diseases lies in the MHC, including HLA-DR4 (RA), HLA-B27 (AS), HLA-DRB1*0301, DRB1*1501/*1503, DRB1*08, and C4 null alleles (SLE), and HLA-DRB1*11 and DRB1*1502 (SSc).
Gene_expression (lies) of DRB1 associated with spinal inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus and disease
8) Confidence 0.19 Published 2005 Journal J Rheumatol Suppl Section Abstract Doc Link 15660456 Disease Relevance 2.00 Pain Relevance 0.69
Much of the genetic contribution to these diseases lies in the MHC, including HLA-DR4 (RA), HLA-B27 (AS), HLA-DRB1*0301, DRB1*1501/*1503, DRB1*08, and C4 null alleles (SLE), and HLA-DRB1*11 and DRB1*1502 (SSc).
Gene_expression (lies) of DRB1 associated with spinal inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus and disease
9) Confidence 0.19 Published 2005 Journal J Rheumatol Suppl Section Abstract Doc Link 15660456 Disease Relevance 1.96 Pain Relevance 0.67
Racial origin and its effect on disease expression and HLA-DRB1 types in patients with rheumatoid arthritis: a matched cross-sectional study.
Gene_expression (expression) of DRB1 associated with pain, rheumatoid arthritis and disease
10) Confidence 0.12 Published 2000 Journal Rheumatology (Oxford) Section Title Doc Link 10952739 Disease Relevance 0.65 Pain Relevance 0.38
Dopamine receptor type 1 (D1R) expressing MSNs in the striatum compose the “direct pathway” (striatonigral), whereas dopamine receptor type 2 (D2R) expressing MSNs in the striatum compose the “indirect pathway” (stiatopallidal) [32].
Gene_expression (expressing) of Dopamine receptor type 1 in MSNs associated with dopamine receptor
11) Confidence 0.07 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.19 Pain Relevance 0.22
Dopamine receptor type 1 (D1R) expressing MSNs in the striatum compose the “direct pathway” (striatonigral), whereas dopamine receptor type 2 (D2R) expressing MSNs in the striatum compose the “indirect pathway” (stiatopallidal) [32].
Gene_expression (expressing) of Dopamine receptor type 1 in MSNs associated with dopamine receptor
12) Confidence 0.05 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.19 Pain Relevance 0.25
Four types of the elongated Met-enkephalins we identified by searching protein databases, (Xl)YGGFMRGY (three frog species and platypus), (Gg)YGGFMRSV (chicken and one fish species), (Hp)YGGFMNGF (shark) and (Mm)YGGFMRSL (mouse and two lungfish species) were chemically synthesized and studied in receptor binding and G-protein activation assays performed on rat brain membranes.
Gene_expression (synthesized) of receptor binding in brain associated with enkephalin
13) Confidence 0.00 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819305 Disease Relevance 0 Pain Relevance 0.51

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