INT65153

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Context Info
Confidence 0.34
First Reported 1995
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 3.29
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DPB1) Golgi apparatus (HLA-DPB1) endoplasmic reticulum (HLA-DPB1)
plasma membrane (HLA-DPB1)
Anatomy Link Frequency
hematopoietic stem cell 1
juvenile 1
central nervous system 1
HLA-DPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 17 99.76 Very High Very High Very High
spinal inflammation 3 97.24 Very High Very High Very High
Central nervous system 2 96.32 Very High Very High Very High
Spinal cord 1 88.32 High High
Neuritis 5 84.60 Quite High
medulla 1 82.60 Quite High
cva 2 25.20 Quite Low
cytokine 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 24 99.76 Very High Very High Very High
Low Back Pain 3 97.24 Very High Very High Very High
Graft Vs Host Disease 26 94.48 High High
Recurrence 2 89.52 High High
Disease 23 86.40 High High
Optic Neuritis 5 84.60 Quite High
Neuromyelitis Optica 3 77.24 Quite High
Iridocyclitis 1 74.88 Quite High
Organ Transplantation 5 53.88 Quite High
General Immunology 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent clinical data indicate that HLA-C matching also affects the clinical outcomes of hematopoietic stem cell transplantation, but HLA-DQ and HLA-DP do not appear critical.27,28
HLA-DP Spec (appear) Binding (critical.27,28) of in hematopoietic stem cell
1) Confidence 0.34 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.22 Pain Relevance 0
HLA-E is an HLA-1b-type molecule of limited polymorphism interacting with natural killer receptors, functioning as an important mediator of cytotoxicity [16-18].
HLA-1b-type Binding (interacting) of
2) Confidence 0.32 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0.20 Pain Relevance 0.07
HLA-DPB1*0501, whose association with OSMS has been reported, was positive only in six patients (including three patients with severe pure OSMS).
HLA-DPB1 Binding (association) of associated with multiple sclerosis
3) Confidence 0.30 Published 2002 Journal Brain Section Abstract Doc Link 12390972 Disease Relevance 1.82 Pain Relevance 0.81
Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders.
HLA-DPB1 Binding (Association) of in central nervous system associated with central nervous system and demyelinating disease
4) Confidence 0.26 Published 2009 Journal Tissue Antigens Section Title Doc Link 19140826 Disease Relevance 0.88 Pain Relevance 0.43
Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis.
DPB1 Binding (Association) of in juvenile associated with spinal inflammation
5) Confidence 0.17 Published 1995 Journal Hum. Immunol. Section Title Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.10

General Comments

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