INT65154

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Context Info
Confidence 0.34
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DPB1) Golgi apparatus (HLA-DPB1) endoplasmic reticulum (HLA-DPB1)
plasma membrane (HLA-DPB1)
Anatomy Link Frequency
T-helper cells 1
HLA-DPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 99.76 Very High Very High Very High
spinal inflammation 4 75.00 Quite High
Inflammation 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High
Iridocyclitis 3 98.04 Very High Very High Very High
Low Back Pain 4 75.00 Quite High
Colon Cancer 3 75.00 Quite High
INFLAMMATION 1 75.00 Quite High
Disease 4 32.32 Quite Low
Autoimmune Disease 5 29.68 Quite Low
Diabetes Mellitus 1 26.72 Quite Low
Celiac Disease 1 23.76 Low Low
Disease Susceptibility 1 15.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result is explained by the high recombination region involving one or several hotspots, which separates HLA-DPB1 from the rest of the other HLA loci.
Positive_regulation (separates) of HLA-DPB1
1) Confidence 0.34 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883542 Disease Relevance 0 Pain Relevance 0
The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b.
Positive_regulation (increase) of DPB1
2) Confidence 0.32 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07
We found an increase of the B*4001, DRB1*08, and DPB1*0301 alleles, as well as the LMP2 b/b genotype (the latter was most pronounced among patients with acute iridocyclitis), in JAS compared to B27-positive controls.
Positive_regulation (increase) of DPB1 associated with iridocyclitis
3) Confidence 0.28 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07
The increase of DRB1*08 and DPB1*0301 was due to an increase of DRB1*08 and DPB1*0301 in combination, whereas the association with B*4001 could be due to linkage disequilibrium with LMP2b.
Positive_regulation (increase) of DPB1
4) Confidence 0.21 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.07
MHC II protein (HLA-DP, -DQ, -DR) levels and infiltration by CD4+ T-helper cells of tumor stroma increased upon NSAID treatment, while CD8+ cytotoxic T-lymphocytes increased in both tumor stroma and epithelium.
Positive_regulation (increased) of HLA-DP in T-helper cells associated with cancer and cinod
5) Confidence 0.03 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.85 Pain Relevance 0.61

General Comments

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