INT6516

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2011
Negated 6
Speculated 2
Reported most in Body
Documents 45
Total Number 48
Disease Relevance 26.61
Pain Relevance 9.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
monocytes 5
osteoblasts 4
pits 2
joint 1
cleavage 1
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 8 99.84 Very High Very High Very High
Arthritis 895 99.80 Very High Very High Very High
Infliximab 13 99.72 Very High Very High Very High
5HT 846 99.48 Very High Very High Very High
endometriosis 110 99.08 Very High Very High Very High
cytokine 147 98.20 Very High Very High Very High
antidepressant 115 98.00 Very High Very High Very High
spondylitis 8 97.88 Very High Very High Very High
Osteoarthritis 401 97.24 Very High Very High Very High
Sumatriptan 30 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ovarian Cancer 219 100.00 Very High Very High Very High
Seronegative Spondarthritis 780 99.80 Very High Very High Very High
Cancer 88 99.70 Very High Very High Very High
Multiple Myeloma 40 99.54 Very High Very High Very High
Hypercalcemia 203 99.52 Very High Very High Very High
Influenza In Birds 9 99.40 Very High Very High Very High
Osteoporosis 229 99.36 Very High Very High Very High
Anxiety Disorder 534 99.20 Very High Very High Very High
Endometriosis 112 99.08 Very High Very High Very High
Low Back Pain 61 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zinc supplementation increased basal IGF-I, IGFBP-3, alkaline phosphatase and osteocalcin without changing GH response to clonidine.
Positive_regulation (increased) of osteocalcin associated with clonidine
1) Confidence 0.67 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 15679071 Disease Relevance 0.13 Pain Relevance 0.30
A longitudinal study [38] showed that the 1-year increase in osteocalcin was associated with loss of joint space width in patients with knee OA over 3 years; however, the baseline measure did not predict progression of joint space narrowing.
Positive_regulation (increase) of osteocalcin in joint associated with osteoarthritis
2) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.90 Pain Relevance 0.34
The urinary cross-linked N-terminal telopeptides of type I collagen and serum bone-specific alkaline phosphatase, osteocalcin, and undercarboxylated osteocalcin levels also markedly decreased.
Positive_regulation (undercarboxylated) of osteocalcin
3) Confidence 0.49 Published 2004 Journal Keio J Med Section Abstract Doc Link 15647630 Disease Relevance 0.59 Pain Relevance 0.24
We analyzed prospectively serum zinc, IGF-I, IGFBP-3, alkaline phosphatase, osteocalcin, and GH response to clonidine test, and performed a somatomedin generation test before and 6 weeks after zinc supplementation in 22 (16 M, 6 F) prepubertal children with idiopathic short stature.
Spec (analyzed) Positive_regulation (response) of osteocalcin associated with growth problems and clonidine
4) Confidence 0.49 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 15679071 Disease Relevance 0.27 Pain Relevance 0.16
Patients had lower serum levels of osteocalcin and higher levels of serum testosterone, luteinizing hormone (LH), and prolactin than controls with a significant statistical difference.
Positive_regulation (levels) of osteocalcin
5) Confidence 0.49 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15592691 Disease Relevance 0.79 Pain Relevance 0.56
Over recent years, it has been shown that bortezomib, the first clinically approved proteasome inhibitor, may increase the markers of bone formation, bALP and osteocalcin, which are usually suppressed in MM.
Positive_regulation (increase) of osteocalcin associated with multiple myeloma
6) Confidence 0.45 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.78 Pain Relevance 0.04
In biochemical terms, post-menopausal osteoporosis leads to minimum modifications of the phospho-calcium metabolism: only during stages of accelerated bone turnover is it possible to observe a small increase in calciuria, hydroxyprolinuria and serum osteocalcin levels.
Positive_regulation (increase) of osteocalcin associated with endometriosis (extended) and osteoporosis
7) Confidence 0.45 Published 1991 Journal Minerva Endocrinol. Section Abstract Doc Link 1770918 Disease Relevance 1.10 Pain Relevance 0.05
Serum biochemical studies revealed elevated alkaline phosphatase activity and osteocalcin levels, mild to moderately increased 1,25-dihydroxyvitamin D concentrations, and normal parathyroid hormone levels.
Positive_regulation (elevated) of osteocalcin in parathyroid
8) Confidence 0.41 Published 1992 Journal Am. J. Med. Section Body Doc Link 1329508 Disease Relevance 0.15 Pain Relevance 0
In normal osteoblasts, LTB(4) dose-dependently stimulated osteocalcin, whereas it failed to influence AP.
Positive_regulation (stimulated) of osteocalcin in osteoblasts
9) Confidence 0.39 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
Whereas the levels of intact osteocalcin rapidly decreases, the total pool of intact osteocalcin and N-MID fragments remains stable in serum, even after repeated freeze thaw cycles or storage at elevated temperatures [31].
Positive_regulation (intact) of osteocalcin
10) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.14 Pain Relevance 0
The reason for this is that circulating osteocalcin is unstable because it contains a tryptic cleavage site at amino acids 43 to 45 near to the carboxyl-terminus [30].
Positive_regulation (circulating) of osteocalcin in cleavage
11) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.14 Pain Relevance 0
Using simple linear regression analyses (Figure 1), we showed that there is a constant increase in the number of OC between 1997 and 2006 (r2 = 0.557, P = 0.013), whereas this increase has not been demonstrated in endometriosis alone (r2 = 0.046, P = 0.550) or endometriosis-associated ovarian cancer (r2 = 0.263, P = 0.123).
Positive_regulation (increase) of OC associated with endometriosis and ovarian cancer
12) Confidence 0.31 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2822768 Disease Relevance 1.55 Pain Relevance 0.33
We showed a constant increase in the number of ovarian cancer (OC) between 1997 and 2006 (r2 = 0.557, P = 0.013), which is not the case for endometriosis (ENDO) or endometriosis-associated ovarian cancer (EAOC).
Positive_regulation (increase) of OC associated with endometriosis and ovarian cancer
13) Confidence 0.31 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2822768 Disease Relevance 2.17 Pain Relevance 0.50
A more recent investigation found a mean decrease in the apparent volume of OC distribution of 40% (95% CI, 37%–44%) and mean reduction in renal elimination of 61% (58%–62%), resulting in an increase in the median AUC for OC of 154% (range, 71%–278%).14
Positive_regulation (increase) of OC
14) Confidence 0.30 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835511 Disease Relevance 0.13 Pain Relevance 0.03
It has been suggested that the release of OC into rivers generates OC resistance in avian influenza in wildfowl (Singer et al. 2007).
Positive_regulation (generates) of OC associated with influenza in birds
15) Confidence 0.29 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.28 Pain Relevance 0
Recent biomarker data generated from ASSERT (Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy) [22,40] showed that previously low levels of osteocalcin and bone alkaline phosphatase were significantly increased under infliximab therapy [41].
Positive_regulation (increased) of osteocalcin associated with low back pain, spondylitis and infliximab
16) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592781 Disease Relevance 0.86 Pain Relevance 0.59
Of note, the osteoblasts from human subchondral bone have already been shown to be mature differentiated cells and, as reported in the literature[12,13,16-21], they express and produce the bone-specific marker alkaline phosphatase, and the level of osteocalcin was drastically increased following vitamin D3 treatment.
Positive_regulation (increased) of osteocalcin in osteoblasts
17) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.96 Pain Relevance 0.37
Furthermore, cells were also treated with vitamin D3, which is known to stimulate both osteocalcin and alkaline phosphatase.
Positive_regulation (stimulate) of osteocalcin
18) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.31 Pain Relevance 0.12
Data showed (Figure 1a,b) that alkaline phosphatase activity and osteocalcin responded to vitamin D3, as is expected from human subchondral bone osteoblasts, with approximately 1.5- and 8-fold increases for alkaline phosphatase and osteocalcin, respectively, over basal values.
Positive_regulation (increases) of osteocalcin in osteoblasts
19) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.76 Pain Relevance 0.27
Human osteocalcin was expressed in the micropores of CP scaffolds and was significantly increased upon co-transplantation of MSCs and CD34+ cells.
Positive_regulation (increased) of osteocalcin
20) Confidence 0.22 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0

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