INT65167

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.36
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC38A5) transmembrane transport (SLC38A5)
Anatomy Link Frequency
bile 1
SLC38A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 16 96.74 Very High Very High Very High
Bile 2 95.52 Very High Very High Very High
Inflammation 22 92.08 High High
Inflammatory mediators 1 89.84 High High
Pain 32 75.84 Quite High
cINOD 8 71.52 Quite High
Dismenorea 1 70.72 Quite High
COX-2 inhibitor 4 16.64 Low Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 48 96.36 Very High Very High Very High
INFLAMMATION 32 92.08 High High
Constipation 30 81.88 Quite High
Pain 6 75.84 Quite High
Rheumatic Diseases 5 73.84 Quite High
Reprotox - General 1 1 70.72 Quite High
Toxicity 3 56.56 Quite High
Stress 21 37.20 Quite Low
Myocardial Infarction 1 10.08 Low Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human milk however, palmitic acid esterified at the sn-2 position of the triacylglycerol molecule is well absorbed as 2-monopalmitin, since it readily forms mixed micelles with bile acids [11,13-15].
Gene_expression (position) of sn-2 in bile associated with bile
1) Confidence 0.59 Published 2007 Journal Nutr J Section Body Doc Link PMC1852321 Disease Relevance 0.06 Pain Relevance 0.05
In human milk 70–85% of palmitic acid is positioned at the sn-2 position of the triacylglycerol molecule, whereas in regular infant formulas 88–94% of palmitic acid is found at the sn-1 and sn-3 position [6-10].
Gene_expression (position) of sn-2
2) Confidence 0.46 Published 2007 Journal Nutr J Section Body Doc Link PMC1852321 Disease Relevance 0.15 Pain Relevance 0
Concentrations of PGE2, PGF2 alpha, and 6-ketoPGF1 alpha in the medium measured by RIA were significantly decreased by the addition of SK, K or GA but no effect was observed when S. 2. [3H]-arachidonic acid (AA) was added to culture medium and incorporated into the Sn-2 of phospholipids. [3H]-AA release and PG production in the medium were determined.
Gene_expression (production) of Sn-2
3) Confidence 0.42 Published 1996 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 8847457 Disease Relevance 0.07 Pain Relevance 0.07
To fully understand the controversy, it must be recalled that Wachtershauser favours an origin of life at high temperature and subsequent evolution from a hyperthermophilic universal ancestor toward mesophilic and psychrophilic descendants, going as far as claiming that the reverse is "impossible" [168] (see however [50] for a discussion proposing mechanisms for progressive adaptation to thermal tolerance and thermophily; see also a recent report giving a striking example of adaptation to thermal tolerance by multiple symbiosis [169]) Wachtershauser therefore has no incentive to suppose that the emergence and segregation of organisms having acquired the capacity to synthesize sn2,3 isoprenoid lipids could have occurred under strong selective pressure for adaptation to high temperature in a mesophilic organism containing only sn1,2 fatty acid lipids, which is exactly what we proposed [29,48] and placed the putative reconversion process in a totally different perspective.
Gene_expression (synthesize) of sn2 associated with tolerance and fever
4) Confidence 0.17 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.19 Pain Relevance 0.10
The occurrence of the divide between sn1,2 (ester/ether-fatty acid) and sn2,3 ether-isoprenoid lipids
Gene_expression (ether) of sn2
5) Confidence 0.15 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.13 Pain Relevance 0
[Author's response: Indeed, the primary divide between sn1,2 and sn2,3 lipids may not be the direct result of selection.
Gene_expression (lipids) of sn2
6) Confidence 0.15 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.14 Pain Relevance 0
Of course, in this view, the so-called "primary divide" between sn1,2 and sn2,3 glycerol lipids now appears as secondary!
Gene_expression (lipids) of sn2
7) Confidence 0.15 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0
PLA2s catalyze the hydrolysis of cell-membrane glycerophospholipids at the sn-2 position leading to the generation of free fatty acids such as arachidonic acid.
Gene_expression (position) of sn-2
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879362 Disease Relevance 0.62 Pain Relevance 0.39

General Comments

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