INT65172

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 37
Disease Relevance 9.89
Pain Relevance 13.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
neurons 4
brain 3
neuronal 3
myocardium 1
dorsal 1
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 59 100.00 Very High Very High Very High
bDMF 38 100.00 Very High Very High Very High
Nerve growth factor 5 100.00 Very High Very High Very High
fluoxetine 230 99.84 Very High Very High Very High
antagonist 15 99.76 Very High Very High Very High
cocaine 6 99.72 Very High Very High Very High
antidepressant 244 99.54 Very High Very High Very High
Mechanosensation 3 99.52 Very High Very High Very High
depression 74 99.48 Very High Very High Very High
Glutamate 19 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 99 99.68 Very High Very High Very High
Ulcers 42 99.68 Very High Very High Very High
Depression 90 99.48 Very High Very High Very High
Urological Neuroanatomy 18 98.12 Very High Very High Very High
Spinal Cord Injury 3 96.48 Very High Very High Very High
Ganglion Cysts 9 96.32 Very High Very High Very High
Neuroblastoma 6 96.12 Very High Very High Very High
Cv Unclassified Under Development 7 95.76 Very High Very High Very High
Myocardial Infarction 71 94.16 High High
Injury 15 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, our data suggest that decreases in TrkB receptor protein at the site of BDNF infusions in the adult brain represent receptor turnover, but this is not associated with altered expression of trkB mRNA or attenuation of the pharmacological effects of BDNF.
Negative_regulation (decreases) of TrkB receptor in adult brain
1) Confidence 0.59 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.15 Pain Relevance 0.22
This decrease in receptor protein, however, was not accompanied by decreased trkB mRNA levels in the olfactory cortex, which is afferent to the bulb.
Negative_regulation (decreased) of trkB mRNA in olfactory cortex
2) Confidence 0.59 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.16 Pain Relevance 0.23
Exposure of embryonic CNS neurons to BDNF in vitro causes down-regulation of TrkB protein and mRNA, and an attenuation of functional responses to acute neurotrophin stimulation.
Negative_regulation (down-regulation) of TrkB in neurons
3) Confidence 0.59 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.08 Pain Relevance 0.26
To determine if BDNF infusion decreased TrkB protein levels in other brain areas and whether trkB mRNA might be down-regulated in the cell bodies of neurons projecting to the infusion site, we infused BDNF into the olfactory bulb.
Negative_regulation (down-regulated) of trkB mRNA in neurons
4) Confidence 0.59 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.16 Pain Relevance 0.28
Interestingly, TrkB protein levels were not accompanied by decreased trkB mRNA levels.
Negative_regulation (decreased) of trkB mRNA
5) Confidence 0.59 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.15 Pain Relevance 0.29
To determine if BDNF infusion decreased TrkB protein levels in other brain areas and whether trkB mRNA might be down-regulated in the cell bodies of neurons projecting to the infusion site, we infused BDNF into the olfactory bulb.
Negative_regulation (decreased) of TrkB in neurons
6) Confidence 0.59 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.15 Pain Relevance 0.29
To test this, we infused the cortex with an inhibitor of Trk receptor tyrosine kinases, anti-TrkB IgG1, anti-BDNF, and anti-neurotrophin 4/5 antibodies.
Negative_regulation (inhibitor) of TrkB in cortex
7) Confidence 0.56 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736347 Disease Relevance 0.96 Pain Relevance 0.51
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
Negative_regulation (decrease) of TrkB associated with antidepressant
8) Confidence 0.52 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.48
Analysis of TrkB receptor levels revealed that at the point when the maximal analgesic effect of BDNF was obtained, there was a concommitant 75% decrease in full-length TrkB protein at the infusion site.
Negative_regulation (decrease) of TrkB associated with analgesic
9) Confidence 0.43 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.15 Pain Relevance 0.32
Following a 12-day infusion of BDNF, TrkB protein levels decreased within the bulb to a similar extent as in the PAG-DR.
Negative_regulation (decreased) of TrkB in bulb associated with urological neuroanatomy
10) Confidence 0.43 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.17 Pain Relevance 0.25
To determine if BDNF infusion decreased TrkB protein levels in other brain areas and whether trkB mRNA might be down-regulated in the cell bodies of neurons projecting to the infusion site, we infused BDNF into the olfactory bulb.
Negative_regulation (down-regulated) of TrkB in neurons
11) Confidence 0.43 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9184109 Disease Relevance 0.16 Pain Relevance 0.29
The current results also show that an acute injection of cocaine results in a decrease in the number of tyrosine kinase B and C receptors immunoreactive neuronal profiles in specific regions of the nucleus accumbens and neostriatum, indicating that cocaine-induced increases in extracellular dopamine in the striatal complex result in compensatory decreases in the expression of tyrosine kinase B and C receptors.
Negative_regulation (decrease) of tyrosine kinase B in nucleus accumbens associated with nucleus accumbens, dopamine and cocaine
12) Confidence 0.42 Published 2003 Journal Neuroscience Section Abstract Doc Link 12605901 Disease Relevance 0 Pain Relevance 0.91
Furthermore, the reductions in Kv currents and mRNA levels of IA subunits in diabetic rats were normalized by pre-treatment with anti-BDNF antibody or K252a, a TrkB tyrosine kinase inhibitor.
Negative_regulation (inhibitor) of TrkB associated with diabetes mellitus
13) Confidence 0.42 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20557422 Disease Relevance 1.31 Pain Relevance 0.63
Then, we hypothesized that endogenous BNDF and its receptors, TrkB, prevent the induction of LTD.
Negative_regulation (prevent) of TrkB associated with depression
14) Confidence 0.41 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736347 Disease Relevance 0.99 Pain Relevance 0.52
The extracellular levels of glutamate in individual animals correlated to the levels of BDNF and trkB mRNAs in the dorsal CA1 region of the hippocampus.
Negative_regulation (levels) of trkB in dorsal associated with glutamate and hippocampus
15) Confidence 0.41 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.70
Synthesis of the neurotrophic factor brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus have been proposed to be influenced by endogenous glutamate.
Negative_regulation (influenced) of TrkB in brain associated with glutamate and hippocampus
16) Confidence 0.41 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.38
However, the brain-derived neurotrophic factor (BDNF) receptor TrkB decreased by 42.8+/-6%, and remained decreased after 6 weeks of treatment.
Negative_regulation (decreased) of TrkB in brain
17) Confidence 0.39 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.54
It is possible that a diminished availability of full-length TrkB and an enhanced expression of truncated TrkB receptors in the injured cord could play an important role in reducing the effect of BDNF following injury.
Negative_regulation (diminished) of TrkB associated with injury
18) Confidence 0.38 Published 2007 Journal J. Neurotrauma Section Abstract Doc Link 17376001 Disease Relevance 0.40 Pain Relevance 0.33
We found that deprivation of pattern vision in one eye, that leaves luminance detection performance unaffected, is sufficient to reduce brain-derived neurotrophic factor (but not trkB) messenger RNA in the visual cortex of young and adult rats.
Negative_regulation (deprivation) of trkB in brain
19) Confidence 0.37 Published 1995 Journal Neuroscience Section Abstract Doc Link 8848102 Disease Relevance 0 Pain Relevance 0
These results illustrate a novel, plasticity-suppressing effect of endogenous TrkB ligands on mechanosensation and mechanosensory primary afferent axons after spinal deafferentation.
Negative_regulation (effect) of TrkB in spinal associated with mechanosensation and deafferentation
20) Confidence 0.34 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17522325 Disease Relevance 0.40 Pain Relevance 0.37

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