INT6519

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1992
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.71
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRA2C) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C)
cell-cell signaling (ADRA2C) cytoplasm (ADRA2C) signal transducer activity (ADRA2C)
Anatomy Link Frequency
dorsal horn 2
ADRA2C (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 4 99.84 Very High Very High Very High
dorsal root ganglion 3 99.58 Very High Very High Very High
Dorsal horn 3 97.78 Very High Very High Very High
antagonist 1 97.00 Very High Very High Very High
Spinal cord 2 93.12 High High
analgesia 1 86.52 High High
antinociception 1 82.64 Quite High
agonist 4 80.96 Quite High
noradrenaline 1 69.60 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Ganglion Cysts 3 99.58 Very High Very High Very High
Pressure Volume 2 Under Development 1 88.84 High High
Sleep Disorders 1 88.20 High High
Bordatella Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because 20% of dorsal horn alpha2ARs derive from cell bodies that reside in the associated dorsal root ganglion (DRG), it is important to evaluate alpha2AR expression in this tissue as well.
Positive_regulation (important) of Gene_expression (expression) of alpha2AR in dorsal horn associated with ganglion cysts, dorsal root ganglion and dorsal horn
1) Confidence 0.44 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10754615 Disease Relevance 0.38 Pain Relevance 0.66
Cooling augmented alpha 2-adrenergic vasoconstriction produced by clonidine; this effect was reduced by yohimbine, an alpha 2-adrenergic antagonist.
Positive_regulation (augmented) of Gene_expression (produced) of alpha 2-adrenergic associated with antagonist, increased venous pressure under development and clonidine
2) Confidence 0.23 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1329562 Disease Relevance 0.34 Pain Relevance 0.24
The baculovirus expression vector system utilizing the strong polyhedrin gene promoter of the Autographa californica nuclear polyhedrosis virus (AcNPV) was used for high level expression of the two alpha 2-adrenoceptor subtypes alpha 2A-C10 and alpha 2B-C2 in Spodoptera frugiperda (Sf-9) insect cells.
Positive_regulation (used) of Gene_expression (expression) of alpha 2-adrenoceptor
3) Confidence 0.13 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8575536 Disease Relevance 0 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox