INT65204

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Context Info
Confidence 0.07
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC, ADCY1) small molecule metabolic process (ADCY1) extracellular region (PNOC)
plasma membrane (ADCY1) nucleus (ADCY1) GTPase activity (ADCY1)
PNOC (Homo sapiens)
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 2 100.00 Very High Very High Very High
Potency 1 99.92 Very High Very High Very High
agonist 3 99.20 Very High Very High Very High
Opioid 7 96.56 Very High Very High Very High
opioid receptor 4 95.04 Very High Very High Very High
Immobilon 3 93.28 High High
Dynorphin 1 92.16 High High
antagonist 2 89.60 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mutation affects neither the affinity of nociceptin - the natural ORL1 agonist - for the receptor, nor the potency of nociceptin to inhibit adenylyl cyclase via ORL1.
nociceptin Negative_regulation (inhibit) of adenylyl cyclase associated with orphanin, agonist and potency
1) Confidence 0.07 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8849681 Disease Relevance 0 Pain Relevance 1.14

General Comments

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