INT65206

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Context Info
Confidence 0.38
First Reported 1996
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 1.61
Pain Relevance 7.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC) extracellular region (PNOC)
Anatomy Link Frequency
trigeminal ganglion 1
monocytes 1
cerebrospinal fluid 1
brain 1
sensory nerves 1
PNOC (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 76 100.00 Very High Very High Very High
opioid receptor 21 100.00 Very High Very High Very High
agonist 8 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
Potency 1 100.00 Very High Very High Very High
Inflammation 4 98.92 Very High Very High Very High
trigeminal ganglion 3 98.72 Very High Very High Very High
chemokine 6 98.40 Very High Very High Very High
Hyperalgesia 1 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 98.92 Very High Very High Very High
Ganglion Cysts 3 98.28 Very High Very High Very High
Nociception 2 98.04 Very High Very High Very High
Hyperalgesia 5 97.96 Very High Very High Very High
Pain 4 94.56 High High
Stress 1 93.04 High High
Anxiety Disorder 1 92.72 High High
Alcohol Addiction 3 85.60 High High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since its discovery, results of a steady stream of studies have suggested that endogenous nociceptin might be involved in responses to addictive drugs, and that targeting the nociceptin system may be beneficial in treating addictions.
Regulation (targeting) of nociceptin associated with orphanin
1) Confidence 0.38 Published 2010 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 20201819 Disease Relevance 0.40 Pain Relevance 0.59
The purpose of this work was to further investigate the role of sensory nerves in fenoterol-induced sensitization of human airways and the effect of nociceptin, a nociceptin/orphanin FQ (NOP) receptor agonist, on the increase in contraction after fenoterol exposure.
Regulation (effect) of nociceptin in sensory nerves associated with orphanin and agonist
2) Confidence 0.38 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15351928 Disease Relevance 0 Pain Relevance 0.44
The aim of the present work was to examine the effect of nociceptin administration on the pro-inflammatory chemokine expression of human monocytes.
Spec (examine) Regulation (effect) of nociceptin in monocytes associated with chemokine, inflammation and orphanin
3) Confidence 0.33 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.20 Pain Relevance 0.72
The role of the fourth member of the opioid receptor family, the nociceptin or orphanin FQ receptor (ORL), is not as clear as hyperalgesia, analgesia, and no effect was reported after administration of ORL agonists.
Regulation (role) of nociceptin associated with hyperalgesia, orphanin, agonist, opioid receptor and analgesia
4) Confidence 0.33 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273128 Disease Relevance 0.10 Pain Relevance 1.10
Nociceptin immunoreactivity and receptor mRNA in the human trigeminal ganglion.
Regulation (immunoreactivity) of Nociceptin in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and orphanin
5) Confidence 0.26 Published 2003 Journal Brain Res. Section Title Doc Link 12576178 Disease Relevance 0.25 Pain Relevance 1.02
The mutation affects neither the affinity of nociceptin - the natural ORL1 agonist - for the receptor, nor the potency of nociceptin to inhibit adenylyl cyclase via ORL1.
Regulation (affects) of nociceptin associated with orphanin, agonist and potency
6) Confidence 0.22 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8849681 Disease Relevance 0 Pain Relevance 1.15
Similar to opioid receptors, nociceptin binding to the ORL1 receptor was altered by Na+, GTPgammaS and dithiothreitol.
Regulation (altered) of nociceptin associated with orphanin and opioid receptor
7) Confidence 0.16 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9384238 Disease Relevance 0 Pain Relevance 0.86
We examined the effects of supraspinal nocistatin and nocistatin amide, and their interaction with nociceptin on nociceptive behavior in mice, using hotplate response times.
Spec (examined) Regulation (effects) of nocistatin associated with nociception and orphanin
8) Confidence 0.16 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16384642 Disease Relevance 0.34 Pain Relevance 0.44
We examined the effects of supraspinal nocistatin and nocistatin amide, and their interaction with nociceptin on nociceptive behavior in mice, using hotplate response times.
Spec (examined) Regulation (effects) of nocistatin associated with nociception and orphanin
9) Confidence 0.07 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16384642 Disease Relevance 0.34 Pain Relevance 0.44
Effect of neonatal benzpyrene imprinting on the brain serotonin content and nocistatin level in adult male rats.
Regulation (Effect) of nocistatin in brain associated with serotonin
10) Confidence 0.05 Published 2007 Journal Acta Physiol Hung Section Title Doc Link 17853770 Disease Relevance 0 Pain Relevance 0.34
The nocistatin level of cerebrospinal fluid (CSF) significantly decreases, while there is no change in the plasma nocistatin level.
Neg (no) Regulation (change) of nocistatin in cerebrospinal fluid
11) Confidence 0.05 Published 2007 Journal Acta Physiol Hung Section Abstract Doc Link 17853770 Disease Relevance 0 Pain Relevance 0.34

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