INT65208

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
bile 2
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 99.52 Very High Very High Very High
endometriosis 13 94.12 High High
cINOD 1 83.28 Quite High
pain pelvic 1 40.80 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 50 99.56 Very High Very High Very High
Breast Cancer 17 98.96 Very High Very High Very High
Injury 5 98.56 Very High Very High Very High
Head Trauma 7 98.40 Very High Very High Very High
Hypercalcemia 7 95.64 Very High Very High Very High
Endometriosis (extended) 15 94.12 High High
Bone Fracture 4 92.88 High High
Adhesions 1 88.56 High High
INFLAMMATION 1 83.04 Quite High
Ankylosis 1 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments

Background

Positive_regulation (increased) of Positive_regulation (levels) of type I collagen associated with breast cancer and metastasis
1) Confidence 0.14 Published 2003 Journal Breast Cancer Res Section Title Doc Link PMC165019 Disease Relevance 0.87 Pain Relevance 0
Selected dysregulated genes were randomly chosen and validated with RT-PCR and/or Northern/dot-blot analyses, and confirmed up-regulation of collagen alpha2 type I, 2.6-fold; bile salt export pump, 2.0-fold; and down-regulation of N-acetylglucosamine-6-O-sulfotransferase (important in synthesis of L-selectin ligands), 1.7-fold; glycodelin, 51.5-fold; integrin alpha2, 1.8-fold; and B61 (Ephrin A1), 4.5-fold.
Positive_regulation (confirmed) of Positive_regulation (up-regulation) of collagen alpha2 type I in bile associated with bile
2) Confidence 0.01 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.72 Pain Relevance 0.23
Procollagen I (PICP) was significantly increased even in the 1st week, reaching its peak during the 2nd week after injury.
Positive_regulation (reaching) of Positive_regulation (increased) of Procollagen I associated with injury
3) Confidence 0.01 Published 1996 Journal Unfallchirurg Section Abstract Doc Link 8850075 Disease Relevance 1.05 Pain Relevance 0.08

General Comments

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