INT6521

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.19
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ADRA1D) plasma membrane (ADRA1D) cell-cell signaling (ADRA1D)
DNA metabolic process (ADRA1D) signal transducer activity (ADRA1D)
Anatomy Link Frequency
bladder 2
bands 2
ADRA1D (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 56 100.00 Very High Very High Very High
methadone 4 99.40 Very High Very High Very High
Codeine 2 97.76 Very High Very High Very High
Analgesic 4 97.00 Very High Very High Very High
Clonidine 2 96.20 Very High Very High Very High
Patient controlled alalgesia 5 95.24 Very High Very High Very High
Morphine 2 92.16 High High
withdrawal 1 91.08 High High
headache 4 72.68 Quite High
Opioid 6 69.52 Quite High
Disease Link Frequency Relevance Heat
Hematuria 14 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Overactive Bladder 52 99.58 Very High Very High Very High
Urinary Calculi 6 99.52 Very High Very High Very High
Uremia 2 98.88 Very High Very High Very High
Urinary Tract Infection 6 98.08 Very High Very High Very High
Benign Prostatic Hypertrophy 203 95.40 Very High Very High Very High
Lower Urinary Tract Symptoms 88 92.64 High High
Substance Withdrawal Syndrome 1 91.44 High High
Reprotox - General 1 27 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations of methadone protein binding caused by an inhibition of alpha1-acid glycoprotein synthesis by alkylating substances are another possibility for predominantly pharmacokinetically based drug interactions during PCA.
Negative_regulation (inhibition) of Gene_expression (synthesis) of alpha1 associated with patient controlled alalgesia and methadone
1) Confidence 0.57 Published 2002 Journal Clin Pharmacokinet Section Abstract Doc Link 11825096 Disease Relevance 0.22 Pain Relevance 1.71
In contrast, cooling abolished alpha 1-adrenergic vasoconstriction produced by phenylephrine, which was not affected by yohimbine.
Negative_regulation (abolished) of Gene_expression (produced) of alpha 1-adrenergic associated with increased venous pressure under development
2) Confidence 0.31 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1329562 Disease Relevance 0.35 Pain Relevance 0.23
Recent studies demonstrate that 5-alpha-reductase inhibitors are effective in the treatment of BPH-induced hematuria,41 probably through their effect on prostate microvessel density.42 Multiple studies now support the role of short-term 5-alpha-reductase inhibitor monotherapy prior to definitive surgical resection in order to decrease hematuria during and after the procedure.43,44

5-alpha-reductase inhibitor and alpha-adrenergic receptor antagonist combination therapy

Negative_regulation (decrease) of Gene_expression (therapy) of alpha-adrenergic receptor associated with benign prostatic hypertrophy, antagonist and hematuria
3) Confidence 0.29 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.97 Pain Relevance 0.05
There are, however, some clear indications for surgical therapy including acute urinary retention not responsive to a trial of alpha-adrenergic receptor antagonists, recurrent bladder stones, azotemia, recurrent urinary tract infections, and intractable hematuria.11
Negative_regulation (trial) of Gene_expression (antagonists) of alpha-adrenergic receptor in bladder associated with urinary calculi, antagonist, overactive bladder, hematuria, urinary tract infection and uremia
4) Confidence 0.29 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 1.44 Pain Relevance 0.05
In contrast, oxybutynin significantly reduced EEG power in 4 bands: theta, alpha 1, alpha 2, beta 1.
Negative_regulation (reduced) of Gene_expression (theta) of alpha 1 in bands
5) Confidence 0.14 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661617 Disease Relevance 0.21 Pain Relevance 0.11

General Comments

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