INT65210

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Context Info
Confidence 0.70
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.71
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
pons 3
hippocampus 2
medulla 1
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 23 100.00 Very High Very High Very High
Hippocampus 2 100.00 Very High Very High Very High
Thalamus 1 100.00 Very High Very High Very High
MU agonist 6 99.98 Very High Very High Very High
Pain 28 99.58 Very High Very High Very High
narcan 5 99.58 Very High Very High Very High
nociceptor 3 99.58 Very High Very High Very High
midbrain 4 99.24 Very High Very High Very High
amygdala 6 98.64 Very High Very High Very High
medulla 4 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 37 100.00 Very High Very High Very High
Stress 8 97.60 Very High Very High Very High
Hypertrophy 8 96.80 Very High Very High Very High
Hyperalgesia 8 95.12 Very High Very High Very High
Targeted Disruption 6 90.36 High High
Cv General 4 Under Development 10 88.80 High High
Coronary Heart Disease 4 88.08 High High
Neuroblastoma 2 74.76 Quite High
Ganglion Cysts 32 73.48 Quite High
Shock 5 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that repeated administration of a kappa-opioid agonist increases the affinity for PDBu binding to the membrane-bound PKC in rat cortex and midbrain, but not in pons/medulla.
Positive_regulation (increases) of PKC Binding (binding) of in pons associated with medulla, kinase c, mu agonist and midbrain
1) Confidence 0.70 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8850328 Disease Relevance 0 Pain Relevance 0.63
Is protein kinase C (PKC) involved in nociception?
Positive_regulation (involved) of PKC Binding (nociception) of associated with nociception, kinase c and narcan
2) Confidence 0.50 Published 2006 Journal Int. J. Neurosci. Section Title Doc Link 16861172 Disease Relevance 0.40 Pain Relevance 0.83
Re-exposure to the context also increased binding in the thalamus and area CA1 of the hippocampus. [3H]PDBu binds preferentially to PKC in the membrane and, therefore, these results suggest that stress induces the translocation of PKC from its resting compartments in the cytosol to the membrane.
Positive_regulation (increased) of PKC Binding (binds) of in hippocampus associated with stress, kinase c, hippocampus and thalamus
3) Confidence 0.46 Published 1997 Journal Brain Res. Section Abstract Doc Link 9098555 Disease Relevance 0.49 Pain Relevance 0.91
These results suggest that repeated administration of a kappa-opioid agonist increases the affinity for PDBu binding to the membrane-bound PKC in rat cortex and midbrain, but not in pons/medulla.
Positive_regulation (increases) of PKC in medulla Binding (binding) of in pons associated with medulla, kinase c, mu agonist and midbrain
4) Confidence 0.24 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8850328 Disease Relevance 0 Pain Relevance 0.63
I may also be clinically relevant since increased activity in PKC ?
Positive_regulation (increased) of PKC Binding (activity) of
5) Confidence 0.06 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1142330 Disease Relevance 0.69 Pain Relevance 0
TRPV4-Ct forms a Ca2+-sensitive supra-molecular signaling complex made of actin, tubulin as well as nociceptive signaling components PKC?
Positive_regulation (supra) of PKC Binding (complex) of associated with nociception
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.56 Pain Relevance 0.33
TRPV4-Ct forms a Ca2+-sensitive supra-molecular signaling complex made of actin, tubulin as well as nociceptive signaling components PKC?
Positive_regulation (made) of PKC Binding (complex) of associated with nociception
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.56 Pain Relevance 0.33

General Comments

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