INT65211

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 38
Total Number 39
Disease Relevance 14.75
Pain Relevance 16.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neuronal 3
plasma 2
pons 1
medulla 1
spinal cord 1
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 332 100.00 Very High Very High Very High
diabetic neuropathy 94 100.00 Very High Very High Very High
opioid receptor 11 99.98 Very High Very High Very High
Calcium channel 10 99.82 Very High Very High Very High
Hippocampus 21 99.78 Very High Very High Very High
nMDA receptor 33 99.72 Very High Very High Very High
Pain 114 99.58 Very High Very High Very High
nociceptor 7 99.58 Very High Very High Very High
narcan 5 99.58 Very High Very High Very High
dorsal root ganglion 117 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 177 100.00 Very High Very High Very High
Nociception 118 100.00 Very High Very High Very High
Diabetic Neuropathy 99 100.00 Very High Very High Very High
Cardiovascular Disorder Under Development 1 100.00 Very High Very High Very High
Targeted Disruption 33 99.84 Very High Very High Very High
Death 8 99.72 Very High Very High Very High
Cognitive Disorder 30 99.64 Very High Very High Very High
Ganglion Cysts 122 99.48 Very High Very High Very High
Pain 111 99.08 Very High Very High Very High
Hepatopulmonary Syndrome 1 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dissociation constant (KD) of [3H]phorbol 12,13-dibutyrate (PDBu) binding to protein kinase C (PKC) in membranes of rat cortex and midbrain was significantly decreased with no change in the receptor density (Bmax) following 7-d treatment with a kappa-opioid agonist, U-50,488 (20 mg/kg/d, i.p.).
PKC Binding (binding) of in midbrain associated with mu agonist, kinase c and midbrain
1) Confidence 0.48 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8850328 Disease Relevance 0 Pain Relevance 0.56
These results suggest that repeated administration of a kappa-opioid agonist increases the affinity for PDBu binding to the membrane-bound PKC in rat cortex and midbrain, but not in pons/medulla.
PKC Binding (binding) of in pons associated with medulla, kinase c, mu agonist and midbrain
2) Confidence 0.48 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8850328 Disease Relevance 0 Pain Relevance 0.62
Re-exposure to the context also increased binding in the thalamus and area CA1 of the hippocampus. [3H]PDBu binds preferentially to PKC in the membrane and, therefore, these results suggest that stress induces the translocation of PKC from its resting compartments in the cytosol to the membrane.
PKC Binding (binds) of in hippocampus associated with stress, kinase c, hippocampus and thalamus
3) Confidence 0.48 Published 1997 Journal Brain Res. Section Abstract Doc Link 9098555 Disease Relevance 0.48 Pain Relevance 0.90
It was concluded that MS-153 inhibited high voltage-gated calcium channels through interactions with PKC, thereby preventing massive release of glutamate from nerve terminals in ischemic conditions.
PKC Binding (interactions) of in nerve associated with glutamate and calcium channel
4) Confidence 0.46 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10668444 Disease Relevance 0.05 Pain Relevance 0.61
Is protein kinase C (PKC) involved in nociception?
PKC Binding (nociception) of associated with nociception, kinase c and narcan
5) Confidence 0.37 Published 2006 Journal Int. J. Neurosci. Section Title Doc Link 16861172 Disease Relevance 0.40 Pain Relevance 0.83
(Cayman Chemical, Ann Arbor, MI) to inhibit LH-induced progesterone accumulation, the siRNA transfected and control cells (not treated with PKC?
PKC Binding (treated) of associated with kinase c
6) Confidence 0.36 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.17
Interestingly, it has been shown that melatonin activates Ca2+-dependent alpha isoform of protein kinase C (PKC) and binds to Ca2+-activated calmodulin to cause microtubule enlargement and neurite outgrowth, and such effect has been implicated in melatonin’s preservation of neuronal cytoskeletal organization following brain damage.48,49
PKC Binding (binds) of in brain associated with kinase c
7) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 0.39 Pain Relevance 0.34
Because changes in the expression of calcium-dependent protein kinases [protein kinase C (PKC)] are observed during pathological pain in the spinal cord, we examined the possible interactions between PKC and 3alpha5alphaNS at synaptic GABA(A)Rs.
PKC Binding (interactions) of in spinal cord associated with pain, gaba, kinase c and spinal cord
8) Confidence 0.36 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17767496 Disease Relevance 0.36 Pain Relevance 1.04
These results suggest that painful diabetic neuropathy is associated with altered cell-specific expression of the VR1 receptor that is coupled to increased function through PKC-mediated phosphorylation, oligomerization, and targeted expression on the cell surface membrane.
PKC Binding (oligomerization) of associated with painful diabetic neuropathy and kinase c
9) Confidence 0.35 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 0.93 Pain Relevance 0.81
Investigating the interaction between PKC and PKA revealed that although inhibitors of PKA had little effect on PKC-induced modulation of TTX-R INa, inhibitors of PKC significantly attenuated PKA-induced modulation of the current.
PKC Binding (interaction) of associated with kinase c
10) Confidence 0.34 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852572 Disease Relevance 0.07 Pain Relevance 0.54
Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families.
PKC Binding (interaction) of associated with dexamethasone
11) Confidence 0.22 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.05
There are multiple factors implicated in vascular abnormalities under diabetic conditions.31 The matrix in the diabetic vascular wall is altered due to changes in MMP2 and MMP9 expression resulting in an increase in accumulated fibroid substances, which may participate in adversely affecting vascular activity.12,16 The intercellular gap junction connexin proteins are important for maintaining normal vascular tone through passing small molecules between cells, among which Cx40 (connexin 40) is active in the vascular wall and its downregulation results in a compromised pulmonary vascular dilatation.12 Drug intervention normalizes the abnormal Cx43, leading to a recovery of the cardiovascular abnormalities.22 An activated PKC?
PKC Binding (leading) of associated with kinase c, uterine fibroids, diabetes mellitus, congenital anomalies, hepatopulmonary syndrome and cardiovascular disorder under development
12) Confidence 0.22 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.19 Pain Relevance 0.10
We found that the dorsally enriched genes also include several members of the calcium sensor protein family, such as vesicle associated calcium calmodulin binding protein (CAMK IV homolog), PKC?
PKC Binding (associated) of in vesicle
13) Confidence 0.20 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0.07 Pain Relevance 0.62
Interstingly, PKC?
PKC Binding (Interstingly) of
14) Confidence 0.20 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC126259 Disease Relevance 0.52 Pain Relevance 0.36
The dissociation constant (KD) of [3H]phorbol 12,13-dibutyrate (PDBu) binding to protein kinase C (PKC) in membranes of rat cortex and midbrain was significantly decreased with no change in the receptor density (Bmax) following 7-d treatment with a kappa-opioid agonist, U-50,488 (20 mg/kg/d, i.p.).
PKC Binding (binding) of in cortex associated with mu agonist, kinase c and midbrain
15) Confidence 0.16 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8850328 Disease Relevance 0 Pain Relevance 0.56
These results suggest that repeated administration of a kappa-opioid agonist increases the affinity for PDBu binding to the membrane-bound PKC in rat cortex and midbrain, but not in pons/medulla.
PKC Binding (binding) of in medulla associated with medulla, kinase c, mu agonist and midbrain
16) Confidence 0.16 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8850328 Disease Relevance 0 Pain Relevance 0.62
On the other hand, estrogens were shown to limit neuronal damage and death, possibly by signaling through PI3K, PKC, ERK or glycogen synthase kinase 3-?
PKC Binding (signaling) of in neuronal associated with death
17) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.39 Pain Relevance 0.39
The sense sequence of the siRNA cassettes specifically targeting the nucleotides (549-568) of PKC?
PKC Binding (targeting) of
18) Confidence 0.16 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.07 Pain Relevance 0
Therefore, it is possible that ketamine blocks NMDA receptor and inhibits intracellular PKA, PKC or signals activity, and then decreases NR1 phosphorylation.
PKC Binding (intracellular) of associated with kinase c, ketamine and nmda receptor
19) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.74 Pain Relevance 1.66
MARCKS is normally associated with the plasma membrane and translocates to the cytoplasm on phosphorylation by PKC and/or CaM binding (Graff et al. 1989; Arbuzova et al. 2002).
PKC Binding (binding) of in plasma associated with kinase c
20) Confidence 0.15 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.37

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox