INT65214

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Context Info
Confidence 0.48
First Reported 1996
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 54
Total Number 58
Disease Relevance 4.77
Pain Relevance 16.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 2
synapse 2
plasma 1
tail 1
brain 1
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2135 100.00 Very High Very High Very High
Potency 13 100.00 Very High Very High Very High
agonist 98 99.98 Very High Very High Very High
local anesthetic 9 99.76 Very High Very High Very High
cocaine 68 99.74 Very High Very High Very High
opioid receptor 18 99.44 Very High Very High Very High
midbrain 26 99.28 Very High Very High Very High
Neuropeptide 51 98.88 Very High Very High Very High
imagery 69 98.84 Very High Very High Very High
antidepressant 51 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 111 99.60 Very High Very High Very High
Cognitive Disorder 109 98.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 134 98.24 Very High Very High Very High
Death 43 98.12 Very High Very High Very High
Stress 95 97.52 Very High Very High Very High
Opiate Addiction 2 96.48 Very High Very High Very High
Syndrome 1 96.44 Very High Very High Very High
Obesity 44 95.68 Very High Very High Very High
Depression 99 88.80 High High
Apoptosis 2 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RATIONALE: Local anesthetics bind to the dopamine transporter (DAT), inhibit dopamine (DA) uptake and have been reported to have cocaine-like discriminative stimulus effects.
dopamine transporter Binding (bind) of associated with dopamine, cocaine and local anesthetic
1) Confidence 0.48 Published 2001 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11605081 Disease Relevance 0 Pain Relevance 0.81
RATIONALE: Local anesthetics bind to the dopamine transporter (DAT), inhibit dopamine (DA) uptake and have been reported to have cocaine-like discriminative stimulus effects.
DAT Binding (bind) of associated with dopamine, cocaine and local anesthetic
2) Confidence 0.48 Published 2001 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11605081 Disease Relevance 0 Pain Relevance 0.81
Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates.
dopamine transporter Binding (interactions) of associated with dopamine
3) Confidence 0.48 Published 2005 Journal Neuropharmacology Section Title Doc Link 16122767 Disease Relevance 0 Pain Relevance 0.45
Methylphenidate binds to DAT at the presynaptic region of these brain areas and blocks their DA re-uptake, resulting in accumulation of extracellular DA [52].
DAT Binding (binds) of in brain associated with dopamine
4) Confidence 0.47 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0.05 Pain Relevance 0.74
To investigate the cellular basis for potential functional interactions involving opiates active at the delta-opioid receptor (DOR) and psychostimulants that bind selectively to the dopamine transporter (DAT), we examined the electron microscopic localization of their respective antisera in rat AcbSh.
DAT Binding (bind) of associated with dopamine, opioid receptor and opiate
5) Confidence 0.45 Published 1999 Journal Synapse Section Abstract Doc Link 10459166 Disease Relevance 0 Pain Relevance 0.73
To investigate the cellular basis for potential functional interactions involving opiates active at the delta-opioid receptor (DOR) and psychostimulants that bind selectively to the dopamine transporter (DAT), we examined the electron microscopic localization of their respective antisera in rat AcbSh.
dopamine transporter Binding (bind) of associated with dopamine, opioid receptor and opiate
6) Confidence 0.45 Published 1999 Journal Synapse Section Abstract Doc Link 10459166 Disease Relevance 0 Pain Relevance 0.73
In addition, meperidine appears to interact predominantly with the high-affinity component of the dopamine transporter, and this high-affinity component may be the site of importance for the production of cocaine's behavioral effects.
dopamine transporter Binding (interact) of associated with dopamine and cocaine
7) Confidence 0.41 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8851160 Disease Relevance 0 Pain Relevance 0.94
Thus, the co-localization of these two proteins in TGN may be the potential site where the CPE-DAT interaction occurs.
CPE-DAT Binding (interaction) of
8) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.12
Here, in an effort to search for candidate proteins capable of interacting with DAT and affecting DAT trafficking, we identified the protein carboxypeptidase E (CPE).
DAT Binding (interacting) of
9) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.26 Pain Relevance 0.04
In vitro binding assays were performed to provide evidence that DAT and CPE can directly interact with each other.
DAT Binding (interact) of
10) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
While these results demonstrate the presence of the DAT: CPE protein complex in rat striatal tissue, it does not clarify whether the DAT: CPE protein complex is formed through a direct interaction or is mediated indirectly by an accessory binding protein.
DAT Binding (interaction) of
11) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03
These results suggest that diminishing Na(+) gradient and membrane potential may convert DAT to a conformational state that dopamine could easily bind to when gaining free access to its intracellular portion.
DAT Binding (bind) of associated with dopamine
12) Confidence 0.36 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16122767 Disease Relevance 0 Pain Relevance 0.49
Thus, the exact nature of CPE-DAT association, how and where this interaction takes place intracellularly remains to be determined.
CPE-DAT Binding (association) of
13) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.12
Next, to confirm that the selective increase in maximal DAT-mediated DA uptake resulted from DAT-CPE interaction, we tested whether a minigene (MG) encoding sequences of the DAT-CT could block these effects, since coexpressioin of CT tail peptide would act as a competitive inhibitor to the CPE-DAT interaction.
DAT-CPE Binding (interaction) of in tail associated with dopamine
14) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.24
To explore the functional importance of the DAT-CPE interaction, we examined the DAT-mediated DA uptake activity in HEK-293 cells coexpressing CPE.
DAT-CPE Binding (interaction) of associated with dopamine
15) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.14
Recent studies using yeast two-hybrid approaches have successfully identified several proteins that interact with the DAT carboxyl terminus and influence DAT trafficking [16-18].
DAT Binding (interact) of
16) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0.11 Pain Relevance 0.05
The indirect dopamine agonist binds to the dopamine transporter (DAT).
dopamine transporter Binding (binds) of associated with dopamine and agonist
17) Confidence 0.32 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.30 Pain Relevance 0.37
The indirect dopamine agonist binds to the dopamine transporter (DAT).
DAT Binding (binds) of associated with dopamine and agonist
18) Confidence 0.32 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.30 Pain Relevance 0.37
The hypothesis of the present study was that affinity at the DAT and potency as a DA uptake blocker determines potency as a cocaine-like discriminative stimulus among local anesthetics, and maximum DA uptake inhibition determines maximum cocaine-like discriminative stimulus effects.
DAT Spec (like) Binding (affinity) of associated with dopamine, local anesthetic, cocaine and potency
19) Confidence 0.31 Published 2001 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 11605081 Disease Relevance 0 Pain Relevance 0.86
As shown in Fig 1B, GST-DAT-NT was unable to precipitate CPE, strongly suggesting that the interaction between DAT and CPE is mediated specifically by the DAT-CT.
DAT Binding (interaction) of
20) Confidence 0.31 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03

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